(2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル
(2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル 物理性質
- 沸点 :
- 492℃
- 比重(密度) :
- 1.305
- 闪点 :
- 251℃
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- 酸解離定数(Pka):
- -1.22±0.20(Predicted)
- 外見 :
- Solid
- 色:
- Pale Yellow to Light Yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
(2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQN-7351 |
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate |
401564-36-1 |
250mg |
￥18000 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQN-7351 |
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate |
401564-36-1 |
100mg |
￥39600 |
2020-09-21 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQN-7351 |
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate |
401564-36-1 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQN-7351 |
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate |
401564-36-1 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC463700 |
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate |
401564-36-1 |
1g |
￥6300 |
2021-03-23 |
購入 |
(2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル 化学特性,用途語,生産方法
使用
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.
合成
To (2S)-1-tertbutyloxycarbonyl-4-oxa-tetramethyleneimine-2-carboxylic
acid (60.0kg), thiazolidine (30.3kg) and the solution
of N-diisopropylethylamine (118kg) in ethyl acetate (595kg), adds the
solution of 28w% propyl phosphonous acid anhydride (cyclic trimer)
in ethyl acetate (446kg) at 2 ℃-7 ℃, and reaction mixture is stirred 2
hours at 2 ℃-4 ℃.To this reaction mixture, add 15w% aqueous citric acid
solution (600kg) for distributing, and ethyl acetate for water layer
(271kg) is extracted.
The ethyl acetate layer obtaining is mixed, and use
successively 10w% ammonium dibasic phosphate aqueous solution (600kg)
and water (300kg) washing. Ethyl acetate layer is concentrated into
residual quantity 300L, normal heptane (739kg), 23 ℃ of-25 ℃ of
interpolations, and is stirred this mixture 1 hour at 23 ℃-25 ℃, and
stir 2 hours at 1 ℃-5 ℃.
The crystal of precipitation is collected by
filtration, is used normal heptane (164kg) washing drying under reduced
pressure to produce (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester (67.8kg, yield 86%).
(2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル 上流と下流の製品情報
原材料
準備製品
(2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル 生産企業
Global( 229)Suppliers
401564-36-1((2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル)キーワード:
- 401564-36-1
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
- 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbonyl)-, 1,1-diMethylethyl ester, (2S)-
- (2S)-4-oxo-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate
- (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- (2S)-tert-butyl 4-hydroxy-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- Teneligptin interMediate B
- tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- (2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid t-butyl ester
- (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidincarbaxilic acid tert-butyl ester
- (2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acidtert-butylester
- Teneligliptin Intermediate-1
- Teneligliptin Intermediate
- (S)-tert-butyl 3-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- (S)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrolidine-1-carboxylate
- Teneint-G
- tert-butyl(2s)-4-oxo-2-(1,3-thiazolidin-3-yl carbonyl) pyrrolidine-1-carboxylate
- tert-butyl (2S)-4-oxo-2-(1,3-thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- (S)-1-Boc-5-(thiazolidine-3-carbonyl)pyrrolidin-3-one
- (2S) -4-oxo-2- (3-thiazolidinylcarbonyl)
-1-Pyrrolidinecarboxylic acid tert-butyl ester / triliptin intermediate
- 3-((S)-1-tert-butoxycarbonyl-4-oxo-2-pyrrolidinylcarbonyl)-1,3-thiazolidine
- Teneligptin interMediate-1
- Tenaligliptin
- 4-oxo-2-(3-thiazolidinylcarbonyl)-,1,1-dimethylethylester
- 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbon...
- tert-butyl (S)-4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- Ethyl(2)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
- (S)-tert-Butyl4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylat
- Teneliglitpin intermediates
- Tert-butyl (2S) -4-oxo-2-(1,3-Thiazoldine-3yl carboxyl) pyrrolidine-1-carboxylate
- (2S) -4-oxo-2- (3-thiazolylcarbonyl) -1-pyrrolidine carboxylate tert butyl ester
- tert-ブチル (2S)-4-オキソ-2-(1,3-チアゾリジン-3-カルボニル)ピロリジン-1-カルボキシラート
- (2S)-4-オキソ-2-(1,3-チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸=tert-ブチル
- (2S)-4-オキソ-2-(チアゾリジン-3-イルカルボニル)ピロリジン-1-カルボン酸tert-ブチル