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クロラムブシル

クロラムブシル 化学構造式
305-03-3
CAS番号.
305-03-3
化学名:
クロラムブシル
别名:
4-(p-ビス(2-クロロエチル)アミノフェニル)酪酸;4-[p-ビス(2-クロロエチル)アミノフェニル]酪酸;4(pビス(2クロロエチル)アミノフェニル)酪酸;クロランブシル;クロラムブシル;4-[4-[ビス(2-クロロエチル)アミノ]フェニル]酪酸;クロラムブシル (JAN)
英語化学名:
Chlorambucil
英語别名:
cb1348;CB 1348;Cb l348;Ecloril;Elcoril;elcorin;nsc3088;Leukeran;Leukoran;NSC 3088
CBNumber:
CB5270716
化学式:
C14H19Cl2NO2
分子量:
304.21216
MOL File:
305-03-3.mol

クロラムブシル 物理性質

融点 :
65-70 °C
比重(密度) :
1.2486 (rough estimate)
屈折率 :
1.6070 (estimate)
貯蔵温度 :
2-8°C
溶解性:
Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
酸解離定数(Pka):
pKa ~1.3(H2O) (Uncertain)
外見 :
neat
水溶解度 :
<0.01 g/100 mL at 22 ºC
極大吸収波長 (λmax):
588nm(DMSO aq.)(lit.)
Merck :
14,2073
BRN :
999011
安定性::
Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.
InChIKey:
JCKYGMPEJWAADB-UHFFFAOYSA-N
CAS データベース:
305-03-3(CAS DataBase Reference)
NISTの化学物質情報:
Chlorambucil(305-03-3)
EPAの化学物質情報:
Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (305-03-3)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  45-25-36/37/38
Sフレーズ  53-26-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS 番号 ES7525000
国連危険物分類  6.1(b)
容器等級  III
HSコード  29224999
有毒物質データの 305-03-3(Hazardous Substances Data)
毒性 LD50 i.p. in rats: 58.2 mmole/kg (Ross)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H350 発がんのおそれ 発がん性 1A, 1B 危険
注意書き
P201 使用前に取扱説明書を入手すること。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P405 施錠して保管すること。

クロラムブシル 価格 もっと(16)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC021684 クロラムブシル
Chlorambucil
305-03-3 1g ¥27700 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01FLC021684 クロラムブシル
Chlorambucil
305-03-3 5g ¥108900 2018-12-26 購入
東京化成工業 C2939 クロラムブシル >98.0%(GC)(T)
Chlorambucil >98.0%(GC)(T)
305-03-3 1g ¥22700 2018-12-04 購入
東京化成工業 C2939 クロラムブシル >98.0%(GC)(T)
Chlorambucil >98.0%(GC)(T)
305-03-3 200mg ¥5800 2018-12-04 購入
Sigma-Aldrich Japan C0253 クロランブシル
Chlorambucil
305-03-3 1g ¥19200 2018-12-25 購入

クロラムブシル MSDS


Chloroambucil

クロラムブシル 化学特性,用途語,生産方法

用途

慢性リンパ球性白血病や多発性骨髄腫およぴリンパ種などの抗腫瘍薬として、また、関節リウマチや全身性エリテマトーデスおよび急性?慢性糸球体腎炎治療における免疫抑制剤などとして用いられる。

効能

抗悪性腫瘍薬, アルキル化剤

化学的特性

Chlorambucil is a crystalline solid

化学的特性

beige powder

使用

antineoplastic, alkylating agent

使用

Chlorambucil is a alkylating agent that is used as an chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease.

使用

Chlorambucil-d8 is the isotope labelled analogue of Chlorambucil (C324050), an alkylating agent that is used in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Ho dgkin's lymphoma (NHL) and Hodgkin's disease.

使用

tranquilization aid

定義

ChEBI: A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

適応症

Chlorambucil (Leukeran) is an aromatic nitrogen mustard that is intermediate in chemical reactivity between mechlorethamine and melphalan. Its mechanisms of action and range of antitumor activity are similar to theirs. It is well absorbed orally, but detailed information concerning its metabolic fate in humans is lacking.
Chlorambucil is used primarily as daily palliative therapy for chronic lymphocytic leukemia, Waldenstr?om’s macroglobulinemia, myeloma, and other lymphomas.
Bone marrow toxicity is the major side effect of chlorambucil. Nausea is uncommon or mild, and hair loss does not occur. Chlorambucil shares the immunosuppressive, teratogenic, and carcinogenic properties of the nitrogen mustards.

brand name

Leukeran (GlaxoSmithKline.

一般的な説明

Chlorambucil is available as 2-mg tablets for oral administrationin the treatment of Hodgkin’s lymphoma, andchronic lymphocytic leukemia in combination with prednisoneand as a single agent. The mechanisms of resistanceare the same as those seen for other agents of the class suchas mechlorethamine. The agent is well absorbed (75%) uponoral administration and highly protein bound. Metabolism ismediated by CYP and occurs extensively to give severalmetabolites, including the active phenylacetic acid–nitrogenmustard. The drug is eliminated via the kidneys with a terminalelimination half-life of 1.5 hours. Adverse effects includedose-limiting myelosuppression, which are seen asboth leucopenia and thrombocytopenia. Nausea and vomitingoccur less often than for mechlorethamine. Additionaladverse effects include hyperuricemia, azoospermia, amenorrhea,seizures, pulmonary fibrosis, and skin rash.

一般的な説明

White to pale beige crystalline or granular powder with a slight odor. Melting point 65-69°C.

空気と水の反応

Insoluble in water.

反応プロフィール

Chloroambucil is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds .

火災危険

Literature sources indicate that Chloroambucil is nonflammable.

安全性プロファイル

Confirmed carcinogen producing leukemia. Experimental carcinogenic and neoplastigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: convulsions, cough, dyspnea, and interstitial fibrosis. Human reproductive effects by ingestion and possibly other routes: changes in spermatogenesis, menstrual cycle changes or disorders, and teratogenic effects of the fetal urogenital system. Experimental teratogenic and reproductive effects. Human mutation data reported. An anti-neoplastic agent. When heated to decomposition it emits very toxic fumes of Cland NOx.

職業ばく露

Chlorambucil, an anticancer drug, is a derivative of nitrogen mustard. This drug is primarily used as an antineoplastic agent for treating lymphocytic leukemia; malignant lymphomas; follicular lymphoma; and Hodgkin’s disease. The treatments are not curative but do produce some marked remissions. Chlorambucil has also been tested for treatment of chronic hepatitis, rheumatoid arthritis; and as an insect chemosterilant. All of the chemical used in this country is imported from the United Kingdom. Work exposure in the United States would be limited to workers formulating the tablets, or to those patients receiving the drug.

Veterinary Drugs and Treatments

Chlorambucil may be useful in a variety of neoplastic diseases, including lymphocytic leukemia, multiple myeloma, polycythemia vera, macroglobulinemia, and ovarian adenocarcinoma. It may also be useful as adjunctive therapy for some immune-mediated conditions (e.g., glomerulonephritis, inflammatory bowel disease, nonerosive arthritis, or immune-mediated skin disease). It has found favor as a routine treatment for feline pemphigus foliaceous and severe feline eosinophilic granuloma complex due to the drug’s relative lack of toxicity in cats and efficacy.

Carcinogenicity

Chlorambucil is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

輸送方法

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

純化方法

Chlorambucil is recrystallised from pet ether (flat needles) and has a solubility at 20o of 66% in EtOH, 40% in CHCl3, 50% in Me2CO but is insoluble in H2O [Everett et al. J Chem Soc 2386 1953]. [Beilstein 14 IV 1715.] CARCINOGEN.

不和合性

Moisture. Chlorambucil is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water, and a salt that may beharmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates, and dithionites (releasing hydrogen sulfate and oxides of sulfur).

廃棄物の処理

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properlylabel and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Permanganate oxidation, high temperature incineration with scrubbing equipment, or microwave plasma treatment.

法令条例

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Environmental Protection Agency (EPA)
Comprehensive Environmental Response, Compensation, and Liability Act
Reportable quantity (RQ) = 10 lb.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of chlorambucil = U035. Listed as a hazardous constituent of waste.
Food and Drug Administration (FDA)
Chlorambucil is a prescription drug subject to labeling and other requirements.

クロラムブシル 上流と下流の製品情報

原材料

準備製品


クロラムブシル 生産企業

Global( 153)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19917 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21756 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24192 60
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3193 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23962 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58

305-03-3(クロラムブシル)キーワード:


  • 305-03-3
  • CHLORAMBUCIL
  • chloroambucil
  • 4(p-bis(beta-chloroethyl)aminophenyl)butyricacid
  • 4-[Bis(2-chioroethyl)amino]benzenebutanoicacid
  • Ambochlorin
  • Amboclorin
  • Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
  • Butanoic acid, 4-(bis(2-chloroethyl)amino)benzene-
  • butanoicacid,4-[3-[bis(2-chloroethyl)amino]phenyl]-
  • Butyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]-
  • butyricacid,4-(p-(bis(2-chloroethyl)amino)phenyl)
  • CB 1348
  • Cb l348
  • cb1348
  • Chloraminophen
  • Chloraminophene
  • Chlorbutin
  • Chlorbutine
  • Chlorobutin
  • Chlorobutine
  • Ecloril
  • Elcoril
  • elcorin
  • gamma-(p-bis(2-chloroethyl)aminophenyl)butyricacid
  • gamma-(p-di(2-chloroethyl)aminophenyl)butyricacid
  • gamma-[p-Di(2-chloroethyl)aminophenyl]butyric acid
  • Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna
  • kyselina4-(n,n-bis-(2-chlorethyl)-p-aminofenyl)maselna
  • Leukeran
  • Leukeran tablets
  • 4-(p-ビス(2-クロロエチル)アミノフェニル)酪酸
  • 4-[p-ビス(2-クロロエチル)アミノフェニル]酪酸
  • 4(pビス(2クロロエチル)アミノフェニル)酪酸
  • クロランブシル
  • クロラムブシル
  • 4-[4-[ビス(2-クロロエチル)アミノ]フェニル]酪酸
  • クロラムブシル (JAN)
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