ドブタミン 化学特性,用途語,生産方法
効能
強心薬, β1作動薬
使用
Dobutamine is predominantly a β1-agonist, with some activity at β2-
receptors. Its primary effect is an increase in cardiac output as a consequence
of increased contractility and HR and decreased afterload. Systolic arterial
pressure may therefore increase, but peripheral resistance is reduced or
unchanged. It is primarily used as an inotrope (inodilator) in low CO states.
D obutamine increases SA node automaticity and conduction velocity in the
atria, ventricles and AV node, with tachyarrhythmias occurring at higher
doses. Dobutamine is administered as an i.v. infusion at a dose range of 0.5–
40 μg kg–1 min–1.
定義
ChEBI: A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulan
action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
ドブタミン 上流と下流の製品情報
原材料
準備製品