ChemicalBook
Chinese english Germany Korea

DL-α-トコフェロール

DL-α-トコフェロール 化学構造式
10191-41-0
CAS番号.
10191-41-0
化学名:
DL-α-トコフェロール
别名:
DL-α-トコフェロール;2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデシル)-3,4-ジヒドロ-2H-1-ベンゾピラン-6-オール;3,4-ジヒドロ-2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデシル)-2H-1-ベンゾピラン-6-オール;2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデシル)クロマン-6-オール;2-(4,8,12-トリメチルトリデシル)-2,5,7,8-テトラメチル-3,4-ジヒドロ-2H-1-ベンゾピラン-6-オール;2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデカン-1-イル)クロマン-6-オール;DL‐Α‐トコフェロール;DL‐Α‐トコフェロール標準品;ビタミン E;トランスフォーミング増殖因子-Β3 ヒト;トコフェロール (JP17);α- トコフェロール
英語化学名:
DL-α-Tocopherol
英語别名:
3,;8-(4;ecyl)-;ephanyl;TGF-β-3;hTGF-β3;A-TOCOPHEROL;DL-VITAMIN E;4-BroMo-2-(5;FIIN-​
CBNumber:
CB5275357
化学式:
C29H50O2
分子量:
430.71
MOL File:
10191-41-0.mol

DL-α-トコフェロール 物理性質

融点 :
2-4°C
比旋光度 :
[α]D20 - 0.02 - +0.02゜ (neat)
沸点 :
200-220°C 0,1mm
比重(密度) :
0.950 g/mL at 20 °C(lit.)
屈折率 :
n20/D 1.506
闪点 :
240°C
貯蔵温度 :
2-8°C
溶解性:
H2O: insoluble
酸解離定数(Pka):
11.40±0.40(Predicted)
外見 :
Pale yellow oil
水溶解度 :
Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.
Sensitive :
Light Sensitive
Merck :
14,9495
BRN :
94012
InChIKey:
GVJHHUAWPYXKBD-IEOSBIPESA-N
CAS データベース:
10191-41-0(CAS DataBase Reference)
EPAの化学物質情報:
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- (10191-41-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi,T,F
Rフレーズ  36/37/38-39/23/24/25-23/24/25-11
Sフレーズ  26-37/39-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS 番号 GA8746000
8-10-23
TSCA  Yes
HSコード  29362800
有毒物質データの 10191-41-0(Hazardous Substances Data)
消防法 危-4-4-III
化審法 (9)-864
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P370+P378 火災の場合:消火に...を使用すること。
P403+P235 換気の良い場所で保管すること。涼しいところに 置くこと。

DL-α-トコフェロール 価格 もっと(48)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA17039
DL-^a-Tocopherol, 97+%
10191-41-0 50g ¥6910 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01ACSVIT-012N ビタミンE
Vitamin E
10191-41-0 100mg ¥7400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBOT-4363
DL-alpha-Tocopherol
10191-41-0 25g ¥9000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBOT-4363
DL-alpha-Tocopherol
10191-41-0 100g ¥28800 2021-03-23 購入
東京化成工業 T0251 DL-α-トコフェロール >96.0%(GC)
DL-α-Tocopherol >96.0%(GC)
10191-41-0 250g ¥14700 2021-03-23 購入

DL-α-トコフェロール 化学特性,用途語,生産方法

外観

黄色~赤褐色, 澄明の液体

定義

本品は、ビタミンEであり、次の化学式で表される。

溶解性

水に不溶。エタノール, アセトンに可溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。

用途

酸化防止剤、薬理研究用。

化粧品の成分用途

閉塞剤、皮膚コンディショニング剤、酸化防止剤、香料

効能

ビタミンE補充薬

使用上の注意

不活性ガス封入

化学的特性

1mg = 1.1 IU

化学的特性

Alpha tocopherol is a natural product. The PhEur 6.0 describes alpha-tocopherol as a clear, colorless or yellowish-brown, viscous, oily liquid.

使用

dl-α-Tocopherol is the racemic analog of α-Tocopherol (T526125), the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils. dl-α-Tocopherol is an antioxidant that protects cell membrane lipids from oxidative damage.

調製方法

Naturally occurring tocopherols are obtained by the extraction or molecular distillation of steam distillates of vegetable oils; for example, alpha tocopherol occurs in concentrations of 0.1–0.3% in corn, rapeseed, soybean, sunflower, and wheat germ oils.Beta and gamma tocopherol are usually found in natural sources along with alpha tocopherol. Racemic synthetic tocopherols may be prepared by the condensation of the appropriate methylated hydroquinone with racemic isophytol.

応用例(製薬)

Alpha tocopherol is primarily recognized as a source of vitamin E, and the commercially available materials and specifications reflect this purpose. While alpha tocopherol also exhibits antioxidant properties, the beta, delta, and gamma tocopherols are considered to be more effective as antioxidants.
Alpha-tocopherol is a highly lipophilic compound, and is an excellent solvent for many poorly soluble drugs.Of widespread regulatory acceptability, tocopherols are of value in oil- or fat-based pharmaceutical products and are normally used in the concentration range 0.001–0.05% v/v. There is frequently an optimum concentration; thus the autoxidation of linoleic acid and methyl linolenate is reduced at low concentrations of alpha tocopherol, and is accelerated by higher concentrations. Antioxidant effectiveness can be increased by the addition of oil-soluble synergists such as lecithin and ascorbyl palmitate.
Alpha tocopherol may be used as an efficient plasticizer. It has been used in the development of deformable liposomes as topical formulations.
d-Alpha-tocopherol has also been used as a non-ionic surfactant in oral and injectable formulations.

安全性

Tocopherols (vitamin E) occur in many food substances that are consumed as part of the normal diet. The daily nutritional requirement has not been clearly defined but is estimated to be 3.0–20.0 mg. Absorption from the gastrointestinal tract is dependent upon normal pancreatic function and the presence of bile. Tocopherols are widely distributed throughout the body, with some ingested tocopherol metabolized in the liver; excretion of metabolites is via the urine or bile. Individuals with vitamin E deficiency are usually treated by oral administration of tocopherols, although intramuscular and intravenous administration may sometimes be used.
Tocopherols are well tolerated, although excessive oral intake may cause headache, fatigue, weakness, digestive disturbance, and nausea. Prolonged and intensive skin contact may lead to erythema and contact dermatitis.
The use of tocopherols as antioxidants in pharmaceuticals and food products is unlikely to pose any hazard to human health since the daily intake from such uses is small compared with the intake of naturally occurring tocopherols in the diet.
The WHO has set an acceptable daily intake of tocopherol used as an antioxidant at 0.15–2.0 mg/kg body-weight.

貯蔵

Tocopherols are oxidized slowly by atmospheric oxygen and rapidly by ferric and silver salts. Oxidation products include tocopheroxide, tocopherylquinone, and tocopherylhydroquinone, as well as dimers and trimers. Tocopherol esters are more stable to oxidation than the free tocopherols but are in consequence less effective antioxidants.
Tocopherols should be stored under an inert gas, in an airtight container in a cool, dry place and protected from light.

純化方法

Dissolve dl--tocopherol in anhydrous MeOH (15mL/g) cool to -6o for 1hour, then chill in a Dry-ice/acetone bath; crystallisation is induced by scratching with a glass rod. The dl--acetate [52225-20-4] (see DL-vitamin E actetate below) is a viscous yellow liquid with m -7o, b 184o/0.01mm, 224o/0.3mm, d 4 20 0.953, n D 20 1.496. It is used as a standard for Vitamin E activity where the unit of activity is attained with 1mg of pure dl--acetate. [Friedrich “Vitamins” Water de Guyter Publ, Berlin 1988, Beilstein 17/4 V 168.]

不和合性

Tocopherols are incompatible with peroxides and metal ions, especially iron, copper, and silver. Tocopherols may be absorbed into plastic.

規制状況(Regulatory Status)

GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IV injections, powder, lyophilized powder for liposomal suspension; oral capsules, tablets, and topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

DL-α-トコフェロール 上流と下流の製品情報

原材料

準備製品


DL-α-トコフェロール 生産企業

Global( 313)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5382 58

10191-41-0(DL-α-トコフェロール)キーワード:


  • 10191-41-0
  • ALL-RAC-ALPHA-TOCOPHEROL
  • (+/-)-ALPHA-TOCOPHEROL
  • (+/-)-ALPHA-TOCOFEROL
  • ALPHA-TOCOPHEROLUM
  • ALPHA-DL-TOCOPHEROL
  • 5,7,8-TRIMETHYLTOCOL
  • A-TOCOPHEROL
  • IRGANOX E 201
  • DL-TOCOPHEROL
  • DL-VITAMIN E
  • DL-VITAMIN E ALCOHOL
  • DL-PROFECUNDIN
  • DL-PHYTOGERMINE
  • DL-ALL-RAC-ALPHA-TOCOPHEROL
  • DL-ALPHA-TOCOPHEROL
  • DL-ALPHA TOCOPHERYL ACETATE 500
  • D, L-A-TOCOPHEROL
  • DL-5,7,8-TRIMETHYLTOCOL
  • DL-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL
  • RAC-ALPHA-TOCOPHEROL
  • ecyl)-
  • ephanyl
  • TOCOPHEROL, ALPHA-DL-
  • VITAMIN E (DL-FORM)
  • 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromano
  • DL-ALPHA-TOCOPHEROL, PH EUR
  • VITAMIN E (MIXED TOCOPHEROL) NATURAL 50%
  • VITAMIN E OIL, 96-102% USP
  • ALPHA TOCOPHEROL (VITAMIN E ALCOHOL) USP(CRM STANDARD)
  • (±)-α-Tocopherol,DL-all-rac-α-Tocopherol, VitaminE
  • DL-α-トコフェロール
  • 2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデシル)-3,4-ジヒドロ-2H-1-ベンゾピラン-6-オール
  • 3,4-ジヒドロ-2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデシル)-2H-1-ベンゾピラン-6-オール
  • 2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデシル)クロマン-6-オール
  • 2-(4,8,12-トリメチルトリデシル)-2,5,7,8-テトラメチル-3,4-ジヒドロ-2H-1-ベンゾピラン-6-オール
  • 2,5,7,8-テトラメチル-2-(4,8,12-トリメチルトリデカン-1-イル)クロマン-6-オール
  • DL‐Α‐トコフェロール
  • DL‐Α‐トコフェロール標準品
  • ビタミン E
  • トランスフォーミング増殖因子-Β3 ヒト
  • トコフェロール (JP17)
  • α- トコフェロール
  • ビタミン
  • 抗酸化剤
  • 生化学
  • トコフェロール
Copyright 2017 © ChemicalBook. All rights reserved