ラフィノース 化学特性,用途語,生産方法
定義
本品は、サトウダイコン Beta vulgaris の根から得られる三糖類である。
解説
β-D-fructofuranosyl-6-O-α-D-galactopyranosyl-α-D-glucopyranoside．C18H32O16(504.44)．ラフィノースは，メリトリオースともいう．三糖類の一種．サトウダイコン，ワタの実，そのほか植物界に広く分布し，その存在量はオリゴ糖のうちではスクロースの次に多い．
五水和物は融点80 ℃．無水物は融点118～120 ℃．[α]D＋105°(水)．非還元性であり，変旋光を示さない．甘さはスクロースの0.48倍．インベルターゼの作用または希酸で穏やかに加水分解すると，D-フルクトースとメリビオースとを与え，α-ガラクトシダーゼでは，D-ガラクトースとスクロースとを生じる．森北出版「化学辞典（第2版）
化粧品の成分用途
エモリエント剤
化学的特性
Raffinose is a white crystalline powder. It is odorless and has a sweet
taste approximately 10% that of sucrose.
使用
D-(+)-Raffinose is an oligosaccharide and trisaccharide whose physical structure and chemical properties have been shown to affect the stability and crystallization of amorphous sucrose, helping to increase the shelf-life of sucrose-containing foods.
調製方法
Raffinose occurs naturally in Australian manna, cottonseed meal,
and seeds of various food legumes. It can be isolated from beet sugar
molasses through sucrose separation, seed-crystallization, and
filtration.
応用例（製薬）
Raffinose is a trisaccharide carbohydrate that is used as a bulking
agent, blood substitute, stabilizing agent, and water scavenger in
freeze-drying where it acts as a stabilizer for freeze-dried formulations. It is also used as a crystallization inhibitor in sucrose
solutions.
安全性
Raffinose is a naturally occurring trisaccharide investigated for use
in freeze-dried pharmaceutical formulations. It occurs in a number
of plants that are consumed widely.
貯蔵
Raffinose is stable under ordinary conditions of use and storage.
Excessive heat should be avoided to prevent degradation. Thermal decomposition products are carbon monoxide and carbon dioxide.
純化方法
fructo-furanose [17629-30-0 (5H2O), 512-69-6 (anhydrous)] M 594.5, m 8 0o, 80 -82o, +124o (c 10, H2O), [ ] D +105o (c 1 for pentahydrate, H2O), pK 1 12.40, pK 2 13.44, pK 3 13.52. D(+)-Raffinose crystallises from H2O, 90% aqueous EtOH or MeOH as the pentahydrate. The anhydrous sugar has m 132-135o. It has RF 0.8 on TLC (Silica Gel, and 1:3:3 CHCl3/butanone:/MeOH). The undecaacetate has been purified through an alumina column by elution with CHCl3, and recrystallised from EtOH/MeOH/H2O (3:2:5), with m 99-100o, [] D +92.8o (c 5.14, EtOH). [pK : Coccioli & Vicedomini Ann Chim (Rome) 66 269, 275 1976, 1H NMR: Suami et al. Carbohydr Research 26 234 1973, Beilstein 17 III/IV 3801, 17/8 V 403.]
不和合性
Raffinose is incompatible with strong oxidizers.
規制状況(Regulatory Status)
Raffinose is a naturally occurring trisaccharide and is consumed as
part of a normal diet.
ラフィノース 上流と下流の製品情報
原材料
準備製品