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AZD 3759

 化学構造式
1626387-80-1
CAS番号.
1626387-80-1
化学名:
别名:
英語化学名:
AZD 3759
英語别名:
azd3579;AZD3759;CS-1596;AZD-3759;AZD 3759;HY-18750;AZD37591;zorifertinib.;zorifertinibum;AZD3759 Powder
CBNumber:
CB53041786
化学式:
C22H23ClFN5O3
分子量:
459.9
MOL File:
1626387-80-1.mol

AZD 3759 物理性質

沸点 :
571.4±50.0 °C(Predicted)
比重(密度) :
1.358±0.06 g/cm3(Predicted)
酸解離定数(Pka):
6.71±0.40(Predicted)

安全性情報

AZD 3759 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

AZD 3759 化学特性,用途語,生産方法

説明

AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system. 

参考文献

Zeng, Qingbei, et al. "Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI)." Journal of Medicinal Chemistry 58.20(2015):8200.
Yang, Zhenfan, et al. "Abstract LB-217: Antitumor activities of AZD3759, a novel EGFR inhibitor with excellent penetration across central nervous system (CNS), in preclinical animal models." Cancer Research 76.14 Supplement(2016):LB-217-LB-217.
Xiong, S., et al. "Determination of AZD3759 in rat plasma and brain tissue by LC-MS/MS and its application in pharmacokinetic and brain distribution studies." Journal of Pharmaceutical & Biomedical Analysis140(2017):362-366.

AZD 3759 上流と下流の製品情報

原材料

準備製品


AZD 3759 生産企業

Global( 223)Suppliers
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Handan Tongyi New Material Technology Co., Ltd
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Hebei Yirun Sega Biological Technology Co. Ltd
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AFINE CHEMICALS LIMITED
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Beijing Cooperate Pharmaceutical Co.,Ltd
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60

1626387-80-1()キーワード:


  • 1626387-80-1
  • AZD 3759
  • AZD3759
  • AZD-3759
  • (2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
  • HY-18750
  • azd3579
  • 1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-
  • 1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER
  • 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb
  • (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate
  • zorifertinibum
  • AZD3759; AZD-3759; AZD 3759; ZORIFERTINIBUM; ZORIFERTINIB.
  • zorifertinib.
  • 4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl 1-piperazinecarboxylic acid 2,4-dimethyl ester
  • 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carboxylate
  • CS-1596
  • AZD-3759;AZD 3759;;AZD3759
  • AZD37591
  • 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (R)-2,4-dimethylpiperazine-1-carboxylate
  • High Purity Azd 3759 CAS:
  • High Purity Azd3759/Azd-3759 CAS 1626387-80-1 with Steady Supply
  • Anti Cancer Azd3759, High Purity
  • AZD3759 Powder
  • Zorifertinib (AZD3759
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