LDC4297

1453834-21-3

CAS番号.: 1453834-21-3

化学名:

别名:

英語名:: LDC4297

英語别名:: LDC4297;CS-2540;CS-2539;LDC044297;LDC4297;LDC 4297;LDC4297(LDC044297);N-(2-(1H-Pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine;Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-

CBNumber:: CB53171481

化学式:: C23H28N8O

分子量:: 432.52

MOL File:: 1453834-21-3.mol

物理性質

安全性情報

用途語

生産企業 43

LDC4297 物理性質

比重(密度) :: 1.37±0.1 g/cm3(Predicted)

貯蔵温度 :: Store at -20°C

溶解性:: DMF:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:40.0(Max Conc. mg/mL);92.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)

外見 :: A crystalline solid

酸解離定数(Pka):: 8.69±0.10(Predicted)

安全性情報

LDC4297 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

LDC4297 化学特性,用途語,生産方法

説明

LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC₅₀ = <5 nM). It is selective for CDK7 over CDK4, CDK6, and CDK9 (IC₅₀s = >10, >10, and 1.71 μM), however, it also inhibits CDK2 and CDK1 (IC₅₀s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC₅₀ = 24.5 nM). LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC₅₀s = 0.02-1.13 μM).

使用

Cyclin-dependent protein kinase 7 (CDK7) is involved with a broad range of regulatory roles in cell cycle and transcription, which is essential for viral replication. LDC 4297 is a CDK7 inhibitor that can be used to develop antiviral drugs.

LDC4297 上流と下流の製品情報

原材料

準備製品

LDC4297 生産企業

Global( 43)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55

1453834-21-3
LDC4297
LDC4297(LDC044297)
LDC044297
LDC4297;LDC 4297
CS-2539
CS-2540
Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-
N-(2-(1H-Pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine