α-チオグリセロール 化学特性,用途語,生産方法
外観
無色〜ほとんど無色, 澄明の液体
定義
本品は、次の化学式で表される含硫多価アルコールである。
溶解性
水に溶ける。
化粧品の成分用途
パーマネント.ウェーブ用還元剤、還元剤、脱毛剤
効能
保存剤
主な用途
2-メルカプトエタノールは、タンパク質のSH基保護、ジスルフィド結合の切断、粗タンパク抽出など幅広く使用されています。しかし、平成20年の毒物及び劇物取締法改正によって、2-メルカプトエタノール及びこれを含有する製剤が毒物に指定され、規制が厳しくなりました。本品は、2-メルカプトエタノールに代わる新しい還元剤です。SDS-PAGEにより2-メルカプトエタノールと同程度の還元能を有することを確認しております。また、分子生物学用グレードとして、DNase活性、RNase活性確認済みです。
試料用緩衝液中の還元剤として2-メルカプトエタノールと3-メルカプト-1,2-プロパンジオールを用いて比較した。サンプルとしてマウスIgGを用い、各還元剤を加えた試料用緩衝液を添加し、電気泳動を行った。その結果、2-メルカプトエタノールと同程度の還元能が確認できた。
使用上の注意
アルゴン封入
説明
1-Thioglycerol is a reagent used in fluorescence, spectroscopy, and microbiology techniques. Varying the concentration of 1-thioglycerol in the preparation of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) allows a precise way to control the size of the shell, with shell size increasing with increased concentration. It is used as a capping agent in the synthesis of nanocrystals analyzed
via Raman and UV/Vis spectroscopy. Biologically, 1-thioglycerol stimulates porphyrin synthesis and increases glutamyl-tRNA reductase activity in
E. coli grown in an aerobic environment. It was previously a component in hair permanents used to produce waves or curls.
化学的特性
clear colorless to yellowish viscous solution
使用
3-Mercapto-1,2-propanediol has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals. It has also been used in a study that investigated the effect of surface attachment on ligand binding
定義
ChEBI: A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.
調製方法
Monothioglycerol is prepared by heating an ethanolic solution of 3-
chloro-1,2-propanediol with potassium bisulfide.
一般的な説明
1-Thioglycerol stimulates the synthesis of porphyrin in aerobically growing
Escherichia coli. It is an inhibitor of glycerol kinase activity
in vitro and
in situ.
応用例（製薬）
Monothioglycerol is used as an antioxidant in pharmaceutical
formulations, mainly in parenteral preparations.Monothioglycerol
is reported to have some antimicrobial activity.It is also
widely used in cosmetic formulations such as depilating agents.
Therapeutically, monothioglycerol has been used in a 0.02%
w/w aqueous solution to stimulate wound healing, and as a 0.1%
w/w jelly in atrophic rhinitis.
安全性プロファイル
Poison by
intraperitoneal and intravenous routes.
Experimental reproductive effects. Mutation
data reported. Flammable when exposed to
heat or flame; can react with oxidizing
materials. When heated to decomposition it
emits hghly toxic fumes of SOx.
安全性
Monothioglycerol is generally regarded as a relatively nontoxic and
nonirritant material at the concentrations used as a pharmaceutical
excipient. It is used in topical and injectable preparations.
Undiluted monothioglycerol is considered a poison by the IP and
IV routes; it has also been reported to be mutagenic.
LD
50 (cat, IV): 0.22 g/kg
LD
50 (mouse, IP): 0.34 g/kg
LD
50 (rabbit, IV): 0.25 g/kg
LD
50 (rat, IP): 0.39 g/kg
貯蔵
Monothioglycerol is unstable in alkaline solutions. Monothioglycerol
should be stored in a well-closed container in a cool, dry place.
不和合性
Monothioglycerol can react with oxidizing materials.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (IM, IV and
other injections). Included in the Canadian List of Acceptable Nonmedicinal
Ingredients.
α-チオグリセロール 上流と下流の製品情報
原材料
準備製品