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メラトニン

メラトニン 化学構造式
73-31-4
CAS番号.
73-31-4
化学名:
メラトニン
别名:
メラトニン;5-メトキシ-N-アセチルトリプタミン;3-[2-(アセチルアミノ)エチル]-5-メトキシ-1H-インドール;5-メトキシ-3-[2-(アセチルアミノ)エチル]-1H-インドール;5-メトキシ-N-アセチル-1H-インドール-3-エタンアミン;N-[2-(5-メトキシ-1H-インドール-3-イル)エチル]アセトアミド;N-アセチル-5-メトキシトリプタミン;メラトニン標準品;メラトニン (JAN)
英語化学名:
Melatonine
英語别名:
MLT;MLK7;MLT1;primex;mlklak;Circadin;Melovine;MELATONIN;melotonin;MELATONINE
CBNumber:
CB5364927
化学式:
C13H16N2O2
分子量:
232.28
MOL File:
73-31-4.mol

メラトニン 物理性質

融点 :
116.5-118 °C (lit.)
沸点 :
374.44°C (rough estimate)
比重(密度) :
1.1099 (rough estimate)
屈折率 :
1.6450 (estimate)
闪点 :
9℃
貯蔵温度 :
-20°C
溶解性:
Soluble in ethanol to at least 50mg/ml
酸解離定数(Pka):
16.26±0.46(Predicted)
外見 :
Powder
色:
white to off-white
Merck :
14,5816
BRN :
205542
InChIKey:
DRLFMBDRBRZALE-UHFFFAOYSA-N
CAS データベース:
73-31-4(CAS DataBase Reference)
NISTの化学物質情報:
Melatonin(73-31-4)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,F
Rフレーズ  60-39/23/24/25-23/24/25-11
Sフレーズ  24/25-99-53-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS 番号 AC5955000
8-10-23
HSコード  29379000
有毒物質データの 73-31-4(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: > 3200 mg/kg
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P311 医師に連絡すること。

メラトニン 価格 もっと(39)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCM215000
Melatonin
73-31-4 50mg ¥12500 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TRCM215000
Melatonin
73-31-4 250mg ¥13800 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TRCM215000
Melatonin
73-31-4 1g ¥15000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00013171 メラトニン
Melatonin
73-31-4 50mg ¥17900 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCM215000
Melatonin
73-31-4 10g ¥51300 2021-03-23 購入

メラトニン MSDS


Melatonine

メラトニン 化学特性,用途語,生産方法

外観

白色〜うすい褐色, 結晶〜粉末

溶解性

熱水、エタノール及びアセトンに溶ける。

用途

メラトニン(英: Melatonin)は、動物、植物、微生物に存在するホルモンであり、また化学的にN-アセチル-5-メトキシトリプタミン(N-acetyl-5-methoxytryptamine)として知られる。動物では、メラトニンの血中濃度は1日の周期で変化しており、それぞれの生物学的な機能における概日リズムによる同調を行っている。 メラトニンによる多くの生物学的な効果は、メラトニン受容体(英語版)の活性を通して生成され、他にも広範囲にわたる強力な抗酸化物質としての役割によって 特に核DNAやミトコンドリアDNAを保護する。

効能

抗けいれん薬, 脳保護薬, 催眠鎮静薬, メラトニン受容体作動薬

使用上の注意

不活性ガス封入

説明

Melatonin, at times referred to as the “hormone of darkness,” normally is secreted during the night. It is synthesized in the pineal gland, and its secretion is controlled by the suprachiasmatic nucleus, following an endogenous circadian rhythm. Studies indicate that melatonin may

化学的特性

Off-White Powder

天然物の起源

Melatonin is a naturally occurring hormone in the body.

使用

Melatonine can be used in sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger

使用

Immunostimulant;Melatonin receptor ligand

使用

Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

使用

Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase

定義

ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.

世界保健機関(WHO)

Melatonin is promoted as a cure for travel sickness, jet-lag and insomnia and has recently been claimed in the United States to reverse the ageing process. A synthetic version has been freely available from health food shops and pharmacies as a "nutritional supplement" since 1993.

生物活性

Endogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .

臨床応用

Melatonin is most effective in young individuals and appears to be less effective in elderly individuals (possibly because of a decreased number of receptors). Melatonin causes a phase shift of approximately 1 hour per day. This means that the use of melatonin in the morning can delay the onset of evening sleepiness, whereas melatonin taken in the evening has been associated with faster onset of sleep and increased total sleep time. Melatonin is sold as a food supplement in the United States, but it has become popular for use as a hypnotic and for alleviating jet lag (a flight across five or more time zones) and helping to resynchronize individuals who have difficulty adapting to night-shift work. have effects on circadian rhythm and sleep processes. The presence of a pharmacologically specific receptor for melatonin in which the molecular structure is known are referred to as MT1, MT2, and MT3 receptors. The MT1 and MT2 receptors are high-affinity G protein coupled receptors, whereas MT3 is a form of quinone reductase. The MT1 receptor appears to be primarily involved in initiating sleep, whereas the MT2 receptor appears to mediate melatonins effect in the eye, circadian rhythm, and vascular effects. The importance of MT3, although widely distributed in different tissues, is currently unknown. The normal physiological concentration of melatonin observed at night is approximately 100 to 200 pg/mL, and oral doses of 0.1 to 0.3 mg of melatonin are adequate to obtain these concentrations even though melatonin frequently is given at doses of 1 to 10 mg to obtain supraphysiological levels. These higher doses may be the reason for some of the side effects not currently associated with the melatonin receptors.

Veterinary Drugs and Treatments

Melatonin may be useful to treat Alopecia-X in Nordic breeds, canine pattern baldness, or canine recurrent flank alopecia in dogs. It has been used anecdotally for the treatment of sleep cycle disorders in cats and geriatric dogs and to treat phobias and separation anxiety in dogs. Melatonin implants are used in the mink and fox pelt industries to promote the development of luxurious hair coats. Implants are also used to improve early breeding and ovulation rates in sheep and goats. Preliminary research is being done for this purpose in horses also.
In pigs, one study (Bubenik, Ayles et al. 1998) demonstrated that 5 mg/kg in feed reduced the incidence of gastric ulcers in young pigs.

メラトニン 上流と下流の製品情報

原材料

準備製品


メラトニン 生産企業

Global( 611)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Xi'an ZB Biotech Co.,Ltd
+8618591943808
sales01@xazbbio.com CHINA 1598 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
0531-88113608 info@pharmachemm.com CHINA 189 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
Hangzhou Cherry Pharmaceutical Technology Co.,ltd
0571-81636070
0571-81636070 info@cherrypharmatech.com CHINA 199 58
Hebei Lvyang Biotechnology Co.,Ltd
15030198922 +86 15030198922
0311-68052281 manager@ly-biotech.com CHINA 86 58
Wuhan Fortuna Chemical Co., Ltd
86-27-59207850
86-27-59524646 info@fortunachem.com CHINA 2457 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
18802962783
rebecca@tgybio.com CHINA 1218 58
Baoji Guokang Bio-Technology Co., Ltd.
09173909592
09173909592 cngksw@aliyun.com CHINA 9448 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55

73-31-4(メラトニン)キーワード:


  • 73-31-4
  • Melatonin (AS)
  • Melatonine,N-(2-(5-Methoxyindol-3-yl)ethyl)acetaMide
  • MELATONINE FOR SYNTHESIS 1 G
  • MELATONINE FOR SYNTHESIS 5 G
  • Melatonin solution
  • N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE
  • N-(2-(5-methoxyindol-3-yl)ethyl)acetamide
  • MLT
  • Melatonin 0.25
  • Melatonine Synonyms N-(2-(5-methoxyindol-3-yl)ethyl)acetamide
  • N-ACETYL-5-METHOXYTRYPTAMINE
  • MELATONINE
  • MELATONIN
  • 3-(N-ACETYL-2-AMINOETHYL)-5-METHOXYINDOLE
  • 5-METHOXY-N-ACETYLTRYPTAMINE
  • ACETYL-5-METHOXYTRYPTAMINE
  • AKOS BB-4935
  • Melatonin 73-31-4
  • TIMTEC-BB SBB003265
  • JACS-73-31-4
  • Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-
  • Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-
  • Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)ethyl]
  • Melatonin(N-Acetyl-5-methoxytryptamine)
  • 3-N-Acetyl-5-methoxyl tryptamine
  • MELATONIN, 99.5+%
  • MELATONIN F&D VERSION FOR VETERINARY US
  • MELATONIN CRYSTALLINE
  • MELATONIN,(SECONDARY STANDARD)
  • MELATONIN,(PRIMARY STANDARD)
  • メラトニン
  • 5-メトキシ-N-アセチルトリプタミン
  • 3-[2-(アセチルアミノ)エチル]-5-メトキシ-1H-インドール
  • 5-メトキシ-3-[2-(アセチルアミノ)エチル]-1H-インドール
  • 5-メトキシ-N-アセチル-1H-インドール-3-エタンアミン
  • N-[2-(5-メトキシ-1H-インドール-3-イル)エチル]アセトアミド
  • N-アセチル-5-メトキシトリプタミン
  • メラトニン標準品
  • メラトニン (JAN)
  • 構造分類
  • インドール
  • トリプタミン
  • ホルモン
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