エナラプリラート二水和物 化学特性,用途語,生産方法
外観
白色～ほとんど白色, 結晶性粉末～粉末
溶解性
メタノールに溶ける。
用途
薬理・生理作用研究用。
効能
血圧降下薬, アンジオテンシン変換酵素(ACE)阻害薬
説明
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized
in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC
50 value of 5.8 nM
in vitro.
化学的特性
White Solid
定義
ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi
h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
エナラプリラート二水和物 上流と下流の製品情報
原材料
準備製品