ベラパミル

ベラパミル 化学構造式
52-53-9
CAS番号.
52-53-9
化学名:
ベラパミル
别名:
2-(3,4-ジメトキシフェニル)-2-イソプロピル-5-[メチル[2-(3,4-ジメトキシフェニル)エチル]アミノ]ペンタンニトリル;5-[(3,4-ジメトキシフェネチル)メチルアミノ]-2-(3,4-ジメトキシフェニル)-2-イソプロピルバレロニトリル;イプロベラトリル;ジラコラン;バソラン;2-イソプロピル-2-(3,4-ジメトキシフェニル)-5-[(3,4-ジメトキシフェネチル)(メチル)アミノ]ペンタンニトリル;ベラパミル;2-(3,4-ジメトキシフェニル)-2-イソプロピル-5-(N-メチル-3,4-ジメトキシフェネチルアミノ)バレロニトリル;イソプチン;VERAPAMIL HYDROCHLORIDE
英語名:
Verapamil
英語别名:
Vasolan;Dilacoran;VPL;D-365;Lekoptin;VERAPAMIL;verapamile;CP-16533-1;eronitrile;verapaiTiil
CBNumber:
CB5376232
化学式:
C27H38N2O4
分子量:
454.61
MOL File:
52-53-9.mol

ベラパミル 物理性質

融点 :
25°C
沸点 :
243-246 °C (1.3 Pa)
比重(密度) :
1.1267 (rough estimate)
屈折率 :
1.5448
貯蔵温度 :
Keep in dark place,Inert atmosphere,Room temperature
溶解性:
DMSO: 100 mg/mL (219.97 mM)
外見 :
Thick Oil
酸解離定数(Pka):
8.6(at 25℃)
色:
Colourless
CAS データベース:
52-53-9(CAS DataBase Reference)
NISTの化学物質情報:
Verapamil(52-53-9)
EPAの化学物質情報:
Verapamil (52-53-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
有毒物質データの 52-53-9(Hazardous Substances Data)
毒性 LD50 oral in rat: 163mg/kg
絵表示(GHS) GHS hazard pictograms
注意喚起語 警告
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告 GHS hazard pictograms
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P312 飲み込んだ場合:気分が悪い時は医師に連絡する こと。
P302+P352 皮膚に付着した場合:多量の水と石鹸で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ベラパミル 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MPB02195545 Verapamil Hydrochloride
(+/-)-Verapamil Hydrochloride
52-53-9 1g ¥8100 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01MPB02195545 Verapamil Hydrochloride
(+/-)-Verapamil Hydrochloride
52-53-9 5g ¥32500 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01MPB02195545 Verapamil Hydrochloride
(+/-)-Verapamil Hydrochloride
52-53-9 10g ¥56600 2024-03-01 購入

ベラパミル 化学特性,用途語,生産方法

効能

抗不整脈薬, 血管拡張薬, カルシウムチャネル遮断薬

使用

Verapamil is primarily used as an antiarrythmic for treating ventricular arrhythmias; however, currently it is being forced out gradually by adenosine.

定義

ChEBI: A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

一般的な説明

Verapamil, 5-[. Hemodynamically, verapamil causesa change in the preload, afterload, contractility, heart rate,and coronary blood flow. The drug reduces systemic vascularresistance and mean blood pressure, with minor effectson cardiac output.
Verapamil is a synthetic compound possessing slightstructural similarity to papaverine. It can be separated intoits optically active isomers, of which the levorotatory enantiomeris the most potent. It is absorbed rapidly after oraladministration. The drug is metabolized quickly and, as aresult, has low bioavailability. The liver is the main siteof first-pass metabolism, forming several products. Thepreferential metabolic step involves N-dealkylation, followedby O-demethylation, and subsequent conjugation ofthe product before elimination. The metabolites have no significantbiological activity. Verapamil has an eliminationhalf-life of approximately 5 hours.

作用機序

Verapamil is used as an antiarrythmic drug in treating supraventricular arrythmia such as paroxysmal atrial tachycardia, and for controlling atrial fibrillation. By blocking entrance of Ca2+ in the cell, verapamil exhibits a negative inotropic effect, and therefore it cannot be combined with β-adrenoblockers or cynidine since that would lead to an increased inotropic effect.

臨床応用

Verapamil (Isoptin, Covera), in addition to its use as an antiarrhythmic agent, has been employed extensively in the management of variant (Prinzmetal’s) angina and effort-induced angina pectoris. It selectively inhibits the voltage-gated calcium channel that is vital for action potential genesis in slowresponse myocytes, such as those found in the sinoatrial and A-V nodes.
Verapamil is useful for slowing the ventricular response to atrial tachyarrhythmias, such as atrial flutter and fibrillation. Verapamil is also effective in arrhythmias supported by enhanced automaticity, such as ectopic atrial tachycardia and idiopathic left ventricular tachycardia.

副作用

Orally administered verapamil is well tolerated by most patients. Most complaints are of constipation and gastric discomfort. Other complaints include vertigo, headache, nervousness, and pruritus.

予防処置

Verapamil must be used with extreme caution or not at all in patients who are receiving -adrenoceptor blocking agents. Normally, the negative chronotropic effect of verapamil will in part be overcome by an increase in reflex sympathetic tone. The latter is be prevented by simultaneous administration of a β-adrenoceptor blocking agent, which exaggerates the depressant effects of verapamil on heart rate, A-V node conduction, and myocardial contractility. The use of verapamil in children less than 1 year of age is controversial.

ベラパミル 上流と下流の製品情報

原材料

準備製品


ベラパミル 生産企業

Global( 125)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
SHANDONG ZHI SHANG CHEMICAL CO.LTD
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Casorganics US Corp
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career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
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0551-65418671
sales@tnjchem.com China 34572 58
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LUYUNJIA CHEMISTRY XIAMEN LIMITED
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China 5996 58

ベラパミル  スペクトルデータ(1HNMR)


52-53-9(ベラパミル)キーワード:


  • 52-53-9
  • -2-isopropyl-
  • 2-isopropyl-
  • 4-dimethoxy-alpha-(1-methylethyl)-l)-
  • 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylv
  • Benzeneacetonitrile, .alpha.-3-2-(3,4-dimethoxyphenyl)ethylmethylaminopropyl-3,4-dimethoxy-.alpha.-(1-methylethyl)-
  • Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- (9CI)
  • dl-Verapamil
  • NSC 272306NA
  • R,S-Verapamil
  • Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl- (7CI, 8CI)
  • VPL
  • 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-isopropylpentanenitrile
  • (2R)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile
  • 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
  • 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
  • alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
  • (2R)-2-(3,4-diMethoxyphenyl)-5-{[2-(3,4-diMethoxyphenyl)ethyl](Methyl)aMino}-2-(propan-2-yl)pentanenitrile
  • Lekoptin
  • verapamile
  • 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylval
  • 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
  • aleronitrile
  • alpha-((n-methyl-n-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylaceto
  • alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
  • alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino]propyl]-3,4-dimethoxy-alp
  • alpha-isopropyl-alpha-[(n-methyl-n-homoveratryl)-gamma-aminopropyl]-3,4-dimeth
  • Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-
  • benzeneacetonitrile,alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propy
  • CP-16533-1
  • D-365
  • 2-(3,4-ジメトキシフェニル)-2-イソプロピル-5-[メチル[2-(3,4-ジメトキシフェニル)エチル]アミノ]ペンタンニトリル
  • 5-[(3,4-ジメトキシフェネチル)メチルアミノ]-2-(3,4-ジメトキシフェニル)-2-イソプロピルバレロニトリル
  • イプロベラトリル
  • ジラコラン
  • バソラン
  • 2-イソプロピル-2-(3,4-ジメトキシフェニル)-5-[(3,4-ジメトキシフェネチル)(メチル)アミノ]ペンタンニトリル
  • ベラパミル
  • 2-(3,4-ジメトキシフェニル)-2-イソプロピル-5-(N-メチル-3,4-ジメトキシフェネチルアミノ)バレロニトリル
  • イソプチン
  • VERAPAMIL HYDROCHLORIDE
  • カルシウム拮抗薬
  • 冠拡張薬
  • 降圧薬
  • 抗不整脈薬
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