パンクレアチン 化学特性,用途語,生産方法
外観
白色～わずかにうすい褐色, 粉末
定義
本品は、動物の膵臓から得られる酵素である。
溶解性
水に溶ける。
化粧品の成分用途
ヘアコンディショニング剤、酵素剤、皮膚コンディショニング剤
使用上の注意
安定性安定pH:6.0～10.0 安定温度:50℃以下
化学的特性
Pancreatin is a yellowish to cream-colored,
amorphous powder with a strong odor. Slightly soluble
in water. Hazard Identification (based on NFPA-704 M
Rating System): Health 1, Flammability 1, Reactivity 0.
Sparingly soluble in water.
来歴
The first observations and experimental demonstrations that pancreatin could be used to improve protein and fat digestion in animals and human patients are from the 19th century, soon after Claude Bernard had revealed the essential role of pancreatic secretion in the digestion of foods. In 1859, the dutch physician Joseph Alexander Fles showed that the daily intake of calf pancreas extract could restore the digestion of fat in a diabetic patient who suffered from diarrhea and had large amounts of fat in the stools. In 1890, Abelmann showed that the consumption of fresh pig pancreas could improve protein and fat digestion in dogs after surgical removal of the pancreas. This is considered as the first experimental demonstration of enzyme replacement[1].
使用
Hydrolyzes starch into dextrins and sugar Pancreatin from porcine pancreas is used in the treatment of steatorrhea by lipase supplementation therapy and for pancreatic diabetes. It is also used in the removal of formalin-fixed tissues from arterial grafts without causing damage in fiber integrity. Further, it finds uses in contact lenses. In addition to this, it hydrolyzes starch into dextrins and sugar. It is also used to treat conditions responsible for deficiency in pancreatic secretions, such as surgical pancreatectomy, pancreatitis and cystic fibrosis.
生物学の機能
Pancreatin is a supplement that can result in decreased food intake. It is used for digestion, and absorption of food. Your pancreas secretes about one and one half quarts of pancreatic juice daily into the small intestine.
一般的な説明
Pancreatin (Panteric) is a substance obtained from the fresh pancreas of the hog or the ox and contains a mixture of enzymes, principally pancreatic amylase (amylopsin), protease, and pancreatic lipase (steapsin). It converts not less than 25 times its weight of USP Potato Starch Reference Standard into soluble carbohydrates and not less than 25 times its weight of casein into proteoses. It acts best in neutral or faintly alkaline media, and excessive acid or alkali renders it inert. Pancreatin can be prepared by extracting the fresh gland with 25% alcohol or with water and subsequently precipitating with alcohol. Besides the enzymes mentioned, it contains some trypsinogen, which can be activated by intestinal enterokinase; chymotrypsinogen, which is converted by trypsin to chymotrypsin; and carboxypeptidase.
Pancreatin is used largely for predigestion of food and for the preparation of hydrolysates. The value of its enzymes orally must be very small because they are digested by pepsin and acid in the stomach, although some of them may escape into the intestines without change. Even if they are protected by enteric coatings, it is doubtful they could be of great assistance in digestion.
安全性プロファイル
Moderately toxic by subcutaneous and intraperitoneal routes.
職業ばく露
It is an enzyme found in the pancreas
and is used in medicines and in treating leather and
textiles.
不和合性
Dust may form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, alcohols.
パンクレアチン 上流と下流の製品情報
原材料
準備製品