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ジエチルアミン

ジエチルアミン 化学構造式
109-89-7
CAS番号.
109-89-7
化学名:
ジエチルアミン
别名:
ジエチルアミン;1,1'-イミノビスエタン;N-エチルエタンアミン;N-エチルエチルアミン;N,N-ジエチルアミン
英語化学名:
Diethylamine
英語别名:
DEA;detn;ai3-24215;(C2H5)2NH;Diethamine;Dietilamina;Diethylamin;Diaethylamin;DIETHYLAMINE;Dwuetyloamina
CBNumber:
CB5447259
化学式:
C4H11N
分子量:
73.14
MOL File:
109-89-7.mol

ジエチルアミン 物理性質

融点 :
-50 °C (lit.)
沸点 :
55 °C (lit.)
比重(密度) :
0.707 g/mL at 25 °C (lit.)
蒸気密度:
2.5 (vs air)
蒸気圧:
14.14 psi ( 55 °C)
屈折率 :
n20/D 1.385(lit.)
闪点 :
−20 °F
貯蔵温度 :
Store below +30°C.
溶解性:
H2O: soluble1M at 20°C, clear, colorless
酸解離定数(Pka):
11.02(at 40℃)
外見 :
Liquid
色:
Clear colorless
Relative polarity:
0.145
PH:
13 (100g/l, H2O, 20℃)
酸塩基指示薬変色域(pH):
Strong alkaline
臭い (Odor):
Ammoniacal; sharp, fishy.
臭気閾値(Odor Threshold):
0.048ppm
爆発限界(explosive limit):
2.0-11.8%(V)
水溶解度 :
soluble
Sensitive :
Air Sensitive
Merck :
14,3111
BRN :
605268
Henry's Law Constant:
2.56(x 10-5 atm?m3/mol) at 25 °C (Christie and Crisp, 1967)
暴露限界値:
NIOSH REL: TWA 10 ppm (30 mg/m3), STEL 25 ppm (75 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 25 ppm; ACGIH TLV: TWA 5 ppm, STEL 15 ppm (adopted).
安定性::
Stable. Highly flammable. Incompatible with strong oxidizing agents.
InChIKey:
HPNMFZURTQLUMO-UHFFFAOYSA-N
CAS データベース:
109-89-7(CAS DataBase Reference)
NISTの化学物質情報:
Ethanamine, N-ethyl-(109-89-7)
EPAの化学物質情報:
Diethylamine (109-89-7)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,C
Rフレーズ  11-20/21/22-35
Sフレーズ  16-26-29-36/37/39-45-3
RIDADR  UN 1154 3/PG 2
WGK Germany  1
RTECS 番号 HZ8750000
10-23
自然発火温度 594 °F
TSCA  Yes
国連危険物分類  3
容器等級  II
HSコード  29211990
有毒物質データの 109-89-7(Hazardous Substances Data)
毒性 LD50 orally in rats: 540 mg/kg (Smyth)
消防法 危険物第4類第一石油類(水溶性)
化審法 (2)-135
安衛法 57,57-2
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H371 臓器の障害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P264, P270, P309+P311, P405,P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
H402 水生生物に有害 水生環境有害性、急性毒性 3
注意書き
P233 容器を密閉しておくこと。
P240 容器を接地すること/アースをとること。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P271 屋外または換気の良い場所でのみ使用すること。
P273 環境への放出を避けること。

ジエチルアミン 価格 もっと(28)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0104-0177 ジエチルアミン 99.0+% (cGC)
Diethylamine 99.0+% (cGC)
109-89-7 25mL ¥1350 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0104-0177 ジエチルアミン 99.0+% (cGC)
Diethylamine 99.0+% (cGC)
109-89-7 500mL ¥1950 2021-03-23 購入
東京化成工業 D0462 ジエチルアミン >99.0%(GC)
Diethylamine >99.0%(GC)
109-89-7 25mL ¥1600 2021-03-23 購入
東京化成工業 D0462 ジエチルアミン >99.0%(GC)
Diethylamine >99.0%(GC)
109-89-7 500mL ¥2800 2021-03-23 購入
関東化学株式会社(KANTO) 10207-00 ジエチルアミン >98.0%(T)
Diethylamine >98.0%(T)
109-89-7 500mL ¥2000 2021-03-23 購入

ジエチルアミン MSDS


DEA

ジエチルアミン 化学特性,用途語,生産方法

外観

無色澄明の液体

溶解性

水, アルコール, アセトンに易溶。水、エタノール及びアセトンに極めて溶けやすい。

解説

C4H11N(73.14).(C2H5)2NH.第二級アミンの一つ.ヨウ化エチルとアンモニアとの反応で生成する.p-ニトロソジエチルアニリンをアルカリ溶液と加熱しても生成する.アンモニアに似た臭気をもつ無色の可燃性液体.融点-50 ℃,沸点56 ℃.d420"0.7067.nD20"1.3867.共役酸はpKa 10.98.強い塩基性をもつ.亜硝酸の作用によりN-ニトロソアミンを生成する.皮膚,粘膜を刺激する.[CAS 109-89-7]
森北出版「化学辞典(第2版)

用途

医薬品、染料中間体、ゴム薬品、農薬(除草剤)、界面活性剤、塗料

説明

Diethylamine is a colourless, strongly alkaline, fish odour liquid, and highly inflammable. It has an ammonia-like odour and is completely soluble in water. On burning, diethylamine releases ammonia, carbon monoxide, carbon dioxide, and nitrogen oxides. It is incompatible with several chemical substances such as strong oxidisers, acids, cellulose nitrate, some metals, and dicyanofuroxan. N-nitrosamines, many of which are known to be potent carcinogens, may be formed when diethylamine comes in contact with nitrous acid, nitrates, or atmospheres with high nitrous oxide concentrations. The applications of Diethylamine are numerous. Diethylamine is used in the production of pesticides. It is used in a mixture for the production of DEET which goes into the repellents that are found readily in supermarkets for general use. Diethylamine is also mixed with other chemicals to form Diethylaminoethanole, which is used mainly as a corrosion inhibitor in water treatment facilities as well as production of dyes, rubber, resins, and pharmaceuticals. Diethylamine is also used in manufacture of basic chemicals and pharmaceuticals.

物理的性質

Colorless liquid with a fishy, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 60 μg/m3 (20 ppbv) and 180 μg/m3 (60 ppbv), respectively (Hellman and Small, 1974). Diethylamine is a very strong base in aqueous solution (pKb = 3.0). Its chemistry is governed by the unshared electron pair on the nitrogen, thus it tends to react with acids to form salts.

天然物の起源

Diethylamine occurs in low concentrations in food and other biological materials. Concentrations (in p.p.m.) in fresh products include: spinach (15), apples (3), butterbeans (2.4), shelled peas (0.1), bean salad (1.5) and red cabbage (2.4) (HSDB 1989). Pickled vegetables contain 0-3.2 p.p.m. diethylamine while concentrations (in p.p.m.) in other materials include herring (0-5.2), barley (5.7), hops (3.1), boiled beef (2), tobacco leaf (0.1-35) and cigarette smoke concentrate (0-0.4). Interest in the occurrence of diethylamine in foods arises in part because of its possible formation of a carcinogenic N-nitroso derivative (Neurath et al 1977). Diethylamine has been reported in the exhaust from a gasoline engine (Hampton et al 1982).

使用

In flotation agents, resins, dyes, resins, pesticides, rubber chemicals, and pharmaceuticals; selective solvent; polymerization and corrosion inhibitors; petroleum chemicals; electroplating; organic synthesis.

使用

Diethylamine is manufactured by heating ethyl chloride and alcoholic ammonia under pressure or by hydrogenation of aziridines in the presence of catalysts. DEA is used as a solvent, as a rubber accelerator, in the organic synthesis of resins, dyes, pesticides, and pharmaceuticals, in electroplating, and as a polymerization inhibitor. Other applications include uses as a corrosion inhibitor. It was reported noneffective as a skin depigmentator.

使用

In the rubber and petroleum industry; in flotation agents; in resins, dyes, pharmaceuticals

調製方法

Diethylamine is produced using the three methods also used for the manufacture of ethylamine with very slight modification. The most widely used method is the passing of ammonia and ethanol over a catalyst such as alumina or silica (Schweizer et al 1978). Diethylamine can be separated from the mixture by selective distillations and extractions. This secondary amine can also be produced by the other two methods which involve: 1) passing ammonia, ethanol, and hydrogen over a dehydrogenation catalyst; and 2) passing ammonia and an aldehyde or ketone and hydrogen over a hydrogenation catalyst. U.S. production in 1984 is estimated at 19.7 million pounds (HSDB 1989).

定義

ChEBI: A secondary aliphatic amine where both N-substituents are ethyl.

一般的な説明

A clear colorless liquid with an ammonia-like odor. Density 5.9 lb / gal. Flash point -15°F. A respiratory irritant. Corrosive to the eyes and skin. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

空気と水の反応

Highly flammable. Soluble in water. Sensitive to heat. May be sensitive to prolonged exposure to air.

反応プロフィール

Diethylamine is a colourless, strongly alkaline, fish odour liquid, and highly inflammable. It has an ammonia-like odour and is completely soluble in water.Causes ignition on contact with cellulose nitrate. Explodes on contact with dicyanofurazan or dicyanofuroxan. Attacks some forms of plastics, rubber and coatings.
On burning, diethylamine releases ammonia, carbon monoxide, carbon dioxide, and nitrogen oxides. It is incompatible with several chemical substances such as strong oxidisers, acids, cellulose nitrate, some metals, and dicyanofuroxan. N-nitrosamines, many of which are known to be potent carcinogens, may be formed when diethylamine comes in contact with nitrous acid, nitrates, or atmospheres with high nitrous oxide concentrations.

健康ハザード

Diethylamine can be harmful if it is inhaled, swallowed, or in contact with skin. Vapors can irritate the eyes and cause irritation of the respiratory tract, leading to coughing and chest pain. Liquid diethylamine can cause severe burns to the eyes and skin. Vision became misty and halos appeared several hours after workmen were exposed to the vapors of amines such as diethylamine (Grant 1986). The edema of the corneal epithelium, which is principally responsible for the disturbances in vision, clears after one or more days, depending on the severity of exposure. Photophobia and discomfort from roughness of the corneal surface also can occur after greater exposure to the amine.

化学反応性

Reactivity with Water No reaction; Reactivity with Common Materials: No hazardous reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

工業用途

Diethylamine, like many of the other short chain aliphatic amines, has achieved widespread industrial use as an intermediate in the manufacture of a number of commercial products. Among these are included insecticides, pharmaceuticals, textile finishing agents, and corrosion inhibitors (Hawley 1981; Schweizer et al 1978). It is used as a polymerization inhibitor and/or catalyst in the polymer industry and in the manufacture of surfactants and rubber processing accelerators. This amine also is useful as a depilatory agent for animal skins, as a selective solvent for the removal of impurities from oils, fats, and waxes, and as a flotation agent in the petroleum industry (NIOSH/OSHA 1981; HSDB 1989).

安全性プロファイル

Moderately toxic by ingestion, inhalation, and skin contact. A skin and severe eye irritant. Exposure to strong vapor can cause severe cough and chest pains. Contact with liquid can damage eyes, possibly permanently; contact with skin causes necrosis and vesciculation. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. Explodes on contact with dicyanofurazan. Violent reaction with sulfuric acid. Ignites on contact with cellulose nitrate of sufficiently high surface area. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Carcinogenicity

No evidence of mutagenicity was seen in Ames bacterial assays.8 Diethylamine has an ammonia-like odor that is detectable at 0.13ppm.
The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for diethylamine is 5ppm (15mg/m3) with a short-term excursion limit of 15ppm (45mg/m3) and an A4-not classifiable as a human carcinogen designation; there is a notation for skin absorption.

環境運命予測

Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. Diethylamine reacted with NOx in the dark forming diethylnitrosamine. In an outdoor chamber, photooxidation by natural sunlight yielded the following products: diethylnitramine, diethylformamide, diethylacetamide, ethylacetamide, ozone, acetaldehyde, and peroxyacetyl nitrate (Pitts et al., 1978).
Reacts with mineral acids forming water-soluble salts (Morrison and Boyd, 1971).

代謝

Little information is available regarding the metabolism of diethylamine. The amine can be readily absorbed from the respiratory and gastrointestinal tract. It has been reported that following oral administration of diethylamine hydrochloride to humans, much of the amine was recovered in the urine (Beard and Noe 1978). This suggests that it is not readily metabolized and, therefore, may not be a substrate for monoamine oxidase. When administered intraperitoneally to rats, it was moderately inhibitory with respect to liver monoamine oxidase (Valiev 1974). Diethylamine may serve as a precursor for the formation of the reportedly carcinogenic N-nitrosoamines and, indeed, when a diethylamine containing liquid was examined for nitrosation reactions under simulated conditions of the human stomach, N-nitrosodiethylamine was formed (Ziebarth 1985).

貯蔵

Diethylamine should be protected from physical damage. It should be kept stored in a cool, dry, well-ventilated location, away from incompatible chemical substances and away from fi re hazard and smoking areas. The containers should be bonded and grounded for transfer to avoid static sparks. Storage and use areas should be no smoking areas.

純化方法

Dry diethylamine with LiAlH4 or KOH pellets. Reflux with, and distil it from, BaO or KOH. Convert it to the p-toluenesulfonamide and crystallise to constant melting point from dry pet ether (b 90-120o), then hydrolyse with HCl, excess NaOH is added, and the amine is passed through a column of activated alumina. Redistil the amine and dry it with activated alumina before use [Swift J Am Chem Soc 64 115 1942]. [Beilstein 4 III 313.] § A polystyrene diethylaminomethyl supported version is commercially available.

予防処置

Occupational workers and users should be very careful during the use and chemical management of diethylamine. Workers should wear impervious protective clothing, including boots, gloves, a laboratory coat, apron or coveralls, as appropriate, to prevent skin contact. The chemical is very hazardous, corrosive, and harmful, and is a very flammable liquid and vapor. Exposures to vapor may cause fl ash fi re. It causes burns and adverse effects to the cardiovascular system. Workers should use chemical safety goggles and a full-face shield to avoid splashing of the chemical substance. An eye-wash fountain and quickdrench facilities in the work area should be maintained by the chemical management unit.

ジエチルアミン 上流と下流の製品情報

原材料

準備製品

N,N-ジエチルシアナミド テトラエチルチウラムジスルフィド トラピジル ジエチルアミノアセトニトリル ジエチルジチオカルバミン酸亜鉛 5-アミノ-3-メチル-チオフェン-2,4-ジカルボン酸ジメチルエステル 5-[(ジエチルアミノ)スルホニル]-2-メトキシベンゼンジアゾニウム 2-アミノ-4,5,6,7-テトラヒドロベンゾ[b]チオフェン-3-カルボニトリル 2-アミノ-4,5-ジメチルチオフェン-3-カルボニトリル サリチル酸ベンジル 4'-ヨードアセトフェノン N,N-ジエチルニコチンアミド リドカイン注射液 ジエチルジチオカルバミン酸ジエチルアンモニウム 2-クロロ-N,N-ジエチルプロパンアミド エタンシラート 1,2-ジヒドロ-4,6-ジメチル-2-オキソ-3-ピリジンカルボニトリル 5-ブロモ-N,N-ジエチルピリミジン-2-アミン プロカイン塩酸塩 ジエチルアミン 塩酸塩 1-[(4-メチルフェニル)スルホニル]-4-フェニル-4-ピペリジンカルボン酸 モンテルカスト ビス(ジエチルアミノ)クロロホスフィン けい皮酸ベンジル 2-クロロ-4,6-ジメチルピリジン-3-カルボニトリル 1,1-ジエチルグアニジン塩酸塩 ジエチルカルバミン酸 クロリド ファスト レッド ITR N,N-ジエチル-m-トルアミド 3 - ジエチルアミノプロピルアミン ジエチルカルバマジン トリス(ジエチルアミノ)ホスフィン 4,6-ジメチル-1H-ピラゾロ[3,4-B]ピリジン-3-イルアミン

ジエチルアミン 生産企業

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109-89-7(ジエチルアミン)キーワード:


  • 109-89-7
  • (C2H5)2NH
  • ai3-24215
  • detn
  • Diaethylamin
  • Diethamine
  • Diethylamin
  • Dietilamina
  • Dwuetyloamina
  • dwuetyloamina(polish)
  • ethanamine,n-ethyl
  • ethanamine,n-ethyl-
  • N,N-Diethylamin
  • n-ethyl-ethanamin
  • N-ethylethanolamine (diethylamine)
  • DIETHYLAMINE GC STANDARD
  • DiethylamineGr
  • Diethylamine, 98+%
  • Diethylamine, extra pure, 99+%
  • DIETHYLAMINE REAGENT (ACS)
  • DEA
  • Amine diethyl
  • Diethylamine, 99+%
  • DIETHYLAMINE extrapure AR
  • DIETHYLAMINE pure
  • DIETHYLAMINEANDITSHYDROCHLORIDE
  • diaethylamina
  • Diethylamine, Reagent
  • Diethyl Amine Anhydrous
  • 5-Bromo-2-chlorothiophene
  • Diethylamine, 99+%, extra pure
  • ジエチルアミン
  • 1,1'-イミノビスエタン
  • N-エチルエタンアミン
  • N-エチルエチルアミン
  • N,N-ジエチルアミン
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