イカチバント酢酸塩 化学特性,用途語,生産方法
効能
血管性浮腫治療薬, ブラジキニン受容体拮抗薬
商品名
フィラジル (シャイアー・ジャパン)
説明
Although it is a rare disease, HAE is an autosomal dominant disorder
that can be potentially life-threatening when swelling manifests itself
within the upper airways. Antagonism of the constitutively expressed B2
receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic
disorders.Designed to possess enhanced metabolic stability with the
inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against
the inducible B1 receptor) with a K
i of 2.2±0.7 nM, and it is the first
downstream targeting agent to receive regulatory approval. It joins
purified C1 esterase inhibitor, danazol (an attenuated androgen), and
tranexamic acid (an antifibrinolytic agent) as acute and prophylactic
treatments for HAE.
使用
Antagonist (bradykinin).
定義
ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.
イカチバント酢酸塩 上流と下流の製品情報
原材料
準備製品