エスリカルバゼピンアセタート
エスリカルバゼピンアセタート 物理性質
- 融点 :
- 183-185°C
- 沸点 :
- 427.4±55.0 °C(Predicted)
- 比重(密度) :
- 1.32
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 溶解性:
- H2O: 不溶
- 外見 :
- 個体
- 酸解離定数(Pka):
- 13.97±0.40(Predicted)
- 色:
- 白い
- InChIKey:
- QIALRBLEEWJACW-INIZCTEOSA-N
エスリカルバゼピンアセタート 価格
もっと(6)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCE659000 |
酢酸エスリカルバゼピン
Eslicarbazepine Acetate |
236395-14-5 |
50mg |
¥48000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLC463334 |
(S)-5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate |
236395-14-5 |
1g |
¥78100 |
2021-03-23 |
購入 |
東京化成工業
|
E1046 |
エスリカルバゼピンアセタート >98.0%(HPLC)(N)
Eslicarbazepine Acetate
>98.0%(HPLC)(N) |
236395-14-5 |
200mg |
¥12200 |
2024-03-01 |
購入 |
東京化成工業
|
E1046 |
エスリカルバゼピンアセタート >98.0%(HPLC)(N)
Eslicarbazepine Acetate
>98.0%(HPLC)(N) |
236395-14-5 |
1g |
¥38900 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
B5435 |
≥98% (HPLC), solid
BIA 2-093 ≥98% (HPLC), solid |
236395-14-5 |
10mg |
¥27000 |
2024-03-01 |
購入 |
エスリカルバゼピンアセタート 化学特性,用途語,生産方法
外観
白色~ほとんど白色粉末~結晶
効能
抗てんかん薬
説明
Although epilepsy is a neurological disorder with varying etiology
and severity, the common feature is unprovoked, recurring seizures.
Even when traditional AEDs, such as phenobarbital,
phenytoin, carbamazepine, and valproate, control seizure activity, their
effectiveness is hampered by considerable side effects and the tendency
for drug-drug interactions. Designed for improved efficacy and safety,
eslicarbazepine acetate is a third-generation AED that has been approved
as adjunctive therapy for partial-onset seizures with or without secondary generalization. As a member of the carbamazepine family (first generation), it is the prodrug of eslicarbazepine and the active metabolite of
oxcarbazepine (second generation).
.
化学的特性
White to Off-White Solid
定義
ChEBI: The acetate ester, with S configuration, of licarbazepine. An anticonvulsant, it is approved for use in Europe and the United States as an adjunctive therapy for epilepsy.
副作用
The most
common adverse events occurring with an incidence of >2% were dizziness, somnolence, nausea, diplopia, headache, vomiting, abnormal coordination, blurred vision, vertigo, and fatigue. While most of these side effects appeared to be mild to moderate, they did display a dose dependency. Although eslicarbazepine acetate is only contraindicated in patients with a known hypersensitivity to the carbamazepine family of AEDs, caution should be exercised in patients with cardiac conduction abnormalities (potential for prolongations in PR intervals), renal impairment, and in patients of Han Chinese and Thai origin since the presence of HLA-B*1502 allele in these individuals has been shown to be strongly associated with the risk of developing Stevens-Johnson syndrome. Regarding drug interactions, eslicarbazepine acetate may decrease the effectiveness of hormonal contraceptives, so alternative or additional methods of contraception should be considered.
エスリカルバゼピンアセタート 上流と下流の製品情報
原材料
準備製品
エスリカルバゼピンアセタート 生産企業
Global( 224)Suppliers
エスリカルバゼピンアセタート スペクトルデータ(1HNMR)
236395-14-5(エスリカルバゼピンアセタート)キーワード:
- 236395-14-5
- Sep 0002093
- (S)-5-CarbaMoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate
- 5H-Dibenz[b,f]azepine-5-carboxaMide, 10-(acetyloxy)-10,11-dihydro-, (10S)-
- Acetic acid 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10(S)-yl ester
- Eslicarbazepine acetate Impurity
- S-Licarbazepine Acetate
- (10S)-10-(Acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxaMide
- (S)-(-)-10-ACETOXY-10,11-DIHYDRO-5H-DIBENZO/B,F/AZEPINE-5-CARBOXAMIDE-
- S(+)-10-acetoxy-10,11-Dihydro-10-5H-dibenz[b,f]azepine-5-carboxamide
- Aptiom
- BIA 2-093;APTIOM
- Licarbazepine Impurity 4(Licarbazepine Acetate S-Isomer)
- Eslicarbazepine Acetate BIA 2-093
- Licarbazepine Acetate S-Isomer
- EslicarbazepineAcetate>
- Exalief
- Stedesa
- Zebinix
- Eslicarbazepine acetate (racemate)
- Acetic acid 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl ester
- Acetic acid 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-...
- Eslicarbazepine D8 acetate (racemate)
- (S)-10-Acetyloxy-10,11-dihydro-5H-Dibenz[b,f]azepine-5-carboxamide
- Na channels,Beta-secretase,Eslicarbazepine,BACE,inhibit,Eslicarbazepine Acetate,Na+ channels,Sodium Channel,β-Secretase,Inhibitor
- Eslikazepine Acetate
- エスリカルバゼピンアセタート
- (S)-(-)-10-アセトキシ-10,11-ジヒドロ-5H-ジベンゾ[b,f]アゼピン-5-カルボキサミド
- 酢酸エスリカルバゼピン
- エスリカルバゼピン酢酸エステル