TG003
TG003 物理性質
- 融点 :
- 132-132.5 °C
- 沸点 :
- 386.0±42.0 °C(Predicted)
- 比重(密度) :
- 1.237±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO: 33 mg/mL
- 外見 :
- 個体
- 酸解離定数(Pka):
- -1.76±0.20(Predicted)
- 色:
- ペールイエロー
- Sensitive :
- Light Sensitive
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY10398 |
TG003 |
300801-52-9 |
1mg |
￥6400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE921995 |
(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one |
300801-52-9 |
100mg |
￥358300 |
2023-06-01 |
購入 |
|
Sigma-Aldrich Japan
|
T5575 |
≥98% (HPLC)
TG003 ≥98% (HPLC) |
300801-52-9 |
5mg |
￥39200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
T5575 |
≥98% (HPLC)
TG003 ≥98% (HPLC) |
300801-52-9 |
25mg |
￥117000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY10398 |
TG003 |
300801-52-9 |
5mg |
￥28000 |
2024-03-01 |
購入 |
TG003 化学特性,用途語,生産方法
説明
Cdc2-
like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-
rich proteins which play a role in alternative splicing of pre-
mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-
4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC
50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC
50 = 200 nM and >10 μM, respectively). Through suppression of Clk-
mediated phosphorylation, TG003 inhibits SF2/ASF-
dependent splicing of β-
globin pre-
mRNA at 1 μM
in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in
Xenopus.
使用
TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.
Biochem/physiol Actions
TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.
TG003 上流と下流の製品情報
原材料
準備製品
TG003 生産企業
Global( 73)Suppliers
300801-52-9()キーワード:
- 300801-52-9
- Cdc2-Like Kinase Inhibitor, TG003
- TG003/TG-003
- 2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-
- (1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
- 1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
- (Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
- CS-955
- CS-1704
- 1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
- TG003 USP/EP/BP
- (E/Z)-TG003
- (E/Z) TG003,Cyclin dependent kinase,site,tumor,(E/Z)-TG003,Wilm's,(E/Z)-TG-003,splice,inhibit,mutation,Inhibitor,CDK,cancer,(E/Z)TG003,breast