ファモチジン 化学特性,用途語,生産方法
外観
白色～黄色、結晶～粉末
溶解性
希塩酸：試験適合酢酸(100)に溶けやすく、エタノール(95)に溶けにくく、水に極めて溶けにくい。0.5 mol/L塩酸試液に溶ける。
解説
ファモチジン，C8H15N7O2S3(337.45)．白色～帯黄白色の結晶．融点約164 ℃(分解)．氷酢酸に易溶，エタノール，水に難溶，エーテルに不溶．ヒスタミン H2-受容体遮断作用による抗胃潰瘍，十二指腸潰瘍薬として用いられる．LD50 244.4 mg/kg(マウス，静注)．
用途
ヒスタミンH2 受容体遮断剤 です。胃粘膜のヒスタミンH2受容体を遮断し、 胃酸分泌を抑制作用を示します。
用途
ヒスタミンH2 受容体遮断剤
です。胃粘膜のヒスタミンH2 受容体を遮断し、
胃酸分泌抑制作用を示します。
効能
消化性潰瘍薬, H2受容体拮抗薬
商品名
ガスター (LTLファーマ); ガスター (LTLファーマ); ガスター (LTLファーマ); ガスター (LTLファーマ)
説明
Famotidine is a competitive histamine H2-receptor antagonist, and the main pharmacodynamic
effect of famotidine is to cause the inhibition of gastric secretion. Famotidine on
decomposition releases toxic products such as carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), and sulphur oxides (SO2, SO3). Famotidine is a medication that is available both
in prescription and over-the-counter forms. It is used to treat conditions related to the
oesophagus, stomach, and intestines. Some specific famotidine is used for the treatment of
duodenal ulcers, gastric ulcers (stomach ulcers), gastroesophageal reflux disease (GERD),
and pathological hypersecretory conditions that occur when stomach acid is secreted/
produced in very large quantities, an abnormal health condition called ‘Zollinger-Ellison
syndrome’.
化学的特性
White Powder
使用
Contact dermatitis from famotidine, a H2 -receptor
agonist, was described in a nurse. In industry, three
cases were reported due to intermediates of synthesis, 2-
diamino-ethylene-amino-thiazolyl-methylenethiourea-dichloride
and 4-chloromethyl-2-guanidinothiazolenitrochloride.
一般的な説明
Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
接触アレルゲン
Contact dermatitis in a nurse from famotidine, an
H2-receptor agonist, was described. In industry, three
cases were reported due to intermediates of the synthesis
of 2-diamino-ethylene-amino-thiazolyl-methylenethio urea-dichloride, and 4-chloromethyl-2-guanidinothiaz ole-nitrochloride.
臨床応用
Famotidine is a histamine H2-antagonist more potent than cimetidine and
ranitidine. Administered once or twice daily, it is useful in the treatment of
gastric, duodenal and anastomotic ulcers, upper gastrointestinal tract hemorrhage,
reflux esophagitis and Zollinger-Ellison syndrome. Like ranitidine, it is lacking in
antiandrogenic effects.
ファモチジン 上流と下流の製品情報
原材料
準備製品