レボセチリジン
レボセチリジン 物理性質
- 融点 :
- 205-208°C (dec.)
- 沸点 :
- 542.1±45.0 °C(Predicted)
- 比重(密度) :
- 1.237±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 溶解性:
- DMSO: 78 mg/mL (200.57 mM);Ethanol: 78 mg/mL (200.57 mM)
- 酸解離定数(Pka):
- 3.46±0.10(Predicted)
- 水溶解度 :
- Water: 78 mg/mL (200.57 mM)
- BCS Class:
- 3
- CAS データベース:
- 130018-77-8(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
レボセチリジン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
レボセチリジン 化学特性,用途語,生産方法
効能
抗アレルギー薬, H1受容体拮抗薬
説明
The (R)-enantiomer of the second-generation antihistamine cetirizine, levocetirizine,
was first introduced in Germany for seasonal allergic rhinitis (including ocular symptoms),
perennial allergic rhinitis and chronic idiopathic urticaria. The dihydrochloride salt can be
prepared in four steps from optically active 4-chlorobenzhydrylamine obtained by
resolution of its racemate with (+)-tartaric acid. Levocetirizine (eutomer) is a 2-fold more
potent H
1 antagonist than cetirizine whereas the other enantiomer (distomer) is 10-fold
less potent compared to levocetirizine. Pharmacodynamic studies on healthy volunteers
showed that compared to cetirizine, half the dose of levocetirizine (5 mg) was necessary to
obtain similar inhibitory effects in the skin test of histamine-induced wheal and flare as well
as on histamine-induced nasal congestion and nasal resistance. There was no evidence of
chiral inversion of levocetirizine in vivo in several species including human. The daily dose
of drug is rapidly and extensively absorbed in human. Interestingly, its volume of
distribution (0.41 kg/L) is smaller than that of the distomer (0.60 kg/L). The low volume of
distribution is considered as favorable for an antihistamine both in terms of efficacy and
safety. Due to its high metabolic stability and lack of effect on the activities of the major
CYP isoenzymes, levocetirizine is unlikely to cause interactions with other administered
drugs. No clinically relevant effect on electrocardiograms of healthy volunteers was
detected.
化学的特性
Off-White Solid
使用
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
レボセチリジン 上流と下流の製品情報
原材料
準備製品
レボセチリジン 生産企業
Global( 161)Suppliers
130018-77-8(レボセチリジン)キーワード:
- 130018-77-8
- LEVOCETIRIZINE
- alerlisin
- LevocetirizineHydrochloride
- 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
- Cetirizine-d4
- Levocetirizine-d4
- (R)-Cetirizine
- (R)-Cetirizine Dihydrochloride
- 2-[2-[4-[(R)-(4-Chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride
- (R)-Cetirizine-d4
- -2-(2-(4-((4-Chlorophenyl)
- Cetirizine R-Isomer
- 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
- Cetirizine Impurity 20
- (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
- Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
- Levoce/0/2/7/5/9/8/4/7/2/5/5/-tirizine
- Levocetirizine-IP/IHS
- LevocetirizineQ: What is
Levocetirizine Q: What is the CAS Number of
Levocetirizine Q: What is the storage condition of
Levocetirizine
- LEVOCETRIZINE
- (R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride
- Benodanil Impurity 17 (Pyracarbolid)
- Levocetirizine Hydrochloride IP / USP
- Levocetirizine
(R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1- yl)ethoxy)acetic acid
- レボセチリジン
- (R)-セチリジン
- 2-[2-[4-[(αR)-α-(4-クロロフェニル)ベンジル]ピペラジノ]エトキシ]酢酸
- [2-[4-[(αR)-4-クロロベンズヒドリル]ピペラジン-1-イル]エトキシ]酢酸
- 2-[2-[4-[(R)-α-(4-クロロフェニル)ベンジル]ピペラジン-1-イル]エトキシ]酢酸
- 2-[2-[4-[(R)-α-(4-クロロフェニル)ベンジル]ピペラジノ]エトキシ]酢酸
- 2-(2-{4-[(R)-(4-クロロフェニル)(フェニル)メチル]ピペラジン-1-イル}エトキシ)酢酸