塩酸ロメフロキサシン 化学特性,用途語,生産方法
外観
白色～うすい黄色、結晶性粉末～粉末
溶解性
水に溶け、アセトニトリルにほとんど溶けない。
用途
DNA ジャイレースを阻害し、
抗菌作用を示します。
用途
DNA ジャイレースを阻害し、
抗菌作用を示します。
効能
抗菌薬, 核酸合成阻害薬
商品名
バレオン (マイランEPD); ロメフロン (千寿製薬); ロメフロン (千寿製薬); ロメフロン (千寿製薬)
使用上の注意
不活性ガス封入
説明
Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.
化学的特性
White powder with no smell, bitter taste
使用
Fluorinated quinolone antibacterial. DNA gyrase antagonist
定義
ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for
he treatment of otitis externa and otitis media.
参考文献
Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.
塩酸ロメフロキサシン 上流と下流の製品情報
原材料
準備製品