rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] 化学特性,用途語,生産方法
定義
本品は、オレイン酸(*)とグリセリン(*)のモノエステルであり、次の化学式で表される。
参照表示名称：オレイン酸, グリセリン
化粧品の成分用途
エモリエント剤、乳化剤、香料
説明
§ 184.1323(a) Glyceryl monooleate is prepared by esterification of
commercial oleic acid that is derived either from edible sources
or from tall oil fatty acids meeting the requirements of §172.862.
It contains glyceryl monooleate (C21H40O4 and glyceryl esters of
fatty acids present in commercial oleic acid.
化学的特性
Colourless Solid
使用
93% 1-Oleoyl, 7% 2-oleoyl
定義
An antifog agent and dispersant.
調製方法
Glyceryl monooleate is prepared by the esterification of glycerol
with fatty acids, chiefly oleic acid. As the fatty acids are not pure
substances, but rather a mixture of fatty acids, the product obtained
from the esterification will contain a mixture of esters, including
stearic and palmitic. Di- and triesters may also be present. The
composition and, therefore, the physical properties of glyceryl
monooleate may thus vary considerably from manufacturer to
manufacturer; e.g. the melting point may vary from 10–35°C.
応用例（製薬）
Glyceryl monooleate is a polar lipid that swells in water to give
several phases with different rheological properties. It is available
in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the
self-emulsifying grade containing about 5% of an anionic surfactant.
The nonemulsifying grade is used in topical formulations as an
emollient and as an emulsifying agent for water-in-oil emulsions. It
is also a stabilizer for oil-in-water emulsions. The self-emulsifying
grade is used as a primary emulsifier for oil-in-water systems.
Glyceryl monooleate gels in excess water, forming a highly
ordered cubic phase that can be used to sustain the release of
various water-soluble drugs.It is also the basis of mucoadhesive
drug delivery systems.
Glyceryl monooleate is reported to enhance transdermal and
buccal penetration.
安全性プロファイル
When heated to
decomposition it emits acrid smoke and irritating fumes.
安全性
Glyceryl monooleate is used in oral and topical pharmaceutical
formulations and is generally regarded as a relatively nonirritant
and nontoxic excipient.
貯蔵
Glyceryl monooleate should be stored in an airtight container,
protected from light in a cool, dry place.
不和合性
Glyceryl monooleate is incompatible with strong oxidizing agents.
The self-emulsifying grade is incompatible with cationic surfactants.
規制状況(Regulatory Status)
GRAS listed. Included in the FDA Inactive Ingredients Database
(oral capsules, oral powder, oral tablets; creams, controlled-release
transdermal films). Included in nonparenteral medicines licensed in
the UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] 上流と下流の製品情報
原材料
準備製品