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ピペラジン (無水)

ピペラジン (無水) 化学構造式
110-85-0
CAS番号.
110-85-0
化学名:
ピペラジン (無水)
别名:
ピペラジン (無水);ピペラジン;ジスペルミン;アンチレン;ヘキサヒドロピラジン;ルンブリカル;ジエチレンジアミン;ピペラジジン;ジエチレンアミン;ピペラジン(無水);ピペラジン標準品;ピペラジン,無水;ピペラジン, 無水;ピペラジン, 無水, 99%
英語化学名:
Piperazine
英語别名:
Upixon;Uvilon;Vermex;Antepan;Antiren;Eraverm;Pipersol;Worm-away;Lumbrical;Piperazin
CBNumber:
CB5852824
化学式:
C4H10N2
分子量:
86.14
MOL File:
110-85-0.mol

ピペラジン (無水) 物理性質

融点 :
109-112 °C(lit.)
沸点 :
146 °C
比重(密度) :
1,1 g/cm3
蒸気圧:
0.8 mm Hg ( 20 °C)
FEMA :
4250 | PIPERAZINE
屈折率 :
1.4460
闪点 :
65 °C
貯蔵温度 :
Store in dark!
溶解性:
H2O: 0.1 M at 20 °C, clear, colorless
酸解離定数(Pka):
9.83(at 23℃)
外見 :
Crystalline Flakes
色:
White to slightly yellow
PH:
11.0-12.5 (25℃, 0.1M in H2O)
爆発限界(explosive limit):
14%
水溶解度 :
150 g/L (20 ºC)
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.035
λ: 280 nm Amax: 0.010
Sensitive :
Air Sensitive & Hygroscopic
JECFA Number:
1615
Merck :
14,7464
BRN :
102555
安定性::
Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
InChIKey:
GLUUGHFHXGJENI-UHFFFAOYSA-N
CAS データベース:
110-85-0(CAS DataBase Reference)
NISTの化学物質情報:
Piperazine(110-85-0)
EPAの化学物質情報:
Piperazine (110-85-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  C,Xn
Rフレーズ  34-42/43-52/53-62-52-63
Sフレーズ  22-26-36/37/39-45-61
RIDADR  UN 2579 8/PG 3
WGK Germany  1
RTECS 番号 TK7800000
3-8-23
Hazard Note  Harmful/Corrosive
TSCA  Yes
HSコード  2933 59 95
国連危険物分類  8
容器等級  III
有毒物質データの 110-85-0(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 2600 mg/kg LD50 dermal Rabbit 8300 mg/kg
化審法 (5)-953
PRTR法 第一種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ 感作性、呼吸器 1 危険 P261, P285, P304+P341, P342+P311,P501
H361 生殖能または胎児への悪影響のおそれの疑い 生殖毒性 2 警告 P201, P202, P281, P308+P313, P405,P501
注意書き
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P284 呼吸用保護具を着用すること。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P310 ただちに医師に連絡すること。
P405 施錠して保管すること。

ピペラジン (無水) 価格 もっと(26)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA15049 ピペラジン, 無水, 99%
Piperazine, anhydrous, 99%
110-85-0 100g ¥5070 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01USP1541601 ピペラジン
Piperazine
110-85-0 200mg ¥69000 2018-12-26 購入
東京化成工業 P0446 ピペラジン (無水) >98.0%(GC)(T)
Piperazine Anhydrous >98.0%(GC)(T)
110-85-0 500g ¥6200 2018-12-04 購入
東京化成工業 P0446 ピペラジン (無水) >98.0%(GC)(T)
Piperazine Anhydrous >98.0%(GC)(T)
110-85-0 25g ¥2100 2018-12-04 購入
関東化学株式会社(KANTO) 13129-3A ピペラジン(無水) 99%
Piperazine 99%
110-85-0 100g ¥3400 2018-12-13 購入

ピペラジン (無水) 化学特性,用途語,生産方法

外観

白色~うすい黄色, 結晶

用途

アンチモン、ビスマス、金の検出試薬、ウレタン触媒、有機合成原料、医薬中間体原料、駆除薬(ヒト及び動物のぎょう虫やかい虫の駆除)原料、エポキシ樹脂硬化剤)

効能

駆虫薬

使用上の注意

不活性ガス封入

化学的特性

Piperazine is white to cream-colored needles or powder. Characteristic ammonia-like odor. Combustible solids that do not easily ignite.

化学的特性

Colorless to yellow solid; salty taste.

使用

Piperazine is used as an intermediate in themanufacture of dyes, pharmaceuticals, polymers,surfactants, and rubber accelerators.

使用

Labelled Piperazine

使用

keratolytic, antiseborheic

定義

ChEBI: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.

適応症

Piperazine (Vermizine) contains a heterocyclic ring that lacks a carboxyl group. It acts on the musculature of the helminths to cause reversible flaccid paralysis mediated by chloride-dependent hyperpolarization of the muscle membrane. This results in expulsion of the worm. Piperazine acts as an agonist at gated chloride channels on the parasite muscle.
Piperazine has been used with success to treat A. lumbricoides and E. vermicularis infections, although mebendazole is now the agent of choice. Piperazine is administered orally and is readily absorbed from the intestinal tract. Most of the drug is excreted in the urine within 24 hours.
Piperazine is an appropriate alternative to mebendazole for the treatment of ascariasis, especially in the presence of intestinal or biliary obstruction. Cure rates of more than 80% are obtained following a 2-day regimen.
Side effects occasionally include gastrointestinal distress, urticaria, and dizziness. Neurological symptoms of ataxia, hypotonia, visual disturbances, and exacerbations of epilepsy can occur in patients with preexisting renal insufficiency. It should not be used in pregnant women because of the formation of a potentially carcinogenic and teratogenic nitrosamine metabolite. Concomitant use of piperazine and chlorpromazine or pyrantel should be avoided.

brand name

Pincets (Marion Merrell Dow); Pinsirup (Marion Merrell Dow);Adelmintex;Adipalis;Adipalit;Adiver;Ancaris thenium;Ancazine;Antelmina;Antepar (b-w);Anterobius;Anthalazine;Anthelmina;Anticucs;Antivermine;Ascalix;Ascarinex;Ascarivet;Asca-trol no.3;Asepar;Askaripar;Averamexan;Bel-zine;Bioxurin;B-piperazine;Brirel;Candizine;Carudol;Ciperazin;Citrazine;Coopane;Dak;Demovermil;Diatesurico;Dicevermin;Digesan;Dilaurazine;Dispermin;Diurazina;Dowzene;Ecosan;Endorid;Entazin;Equizole-a;Escovermin;Esteropipate;Etaphylline (acetyllinate);Gentiazina;Glycopiparsol;Heksapar;Helmacid;Helmezin;Helmicide;Helmifren;Helmipar;Helmirazine (adipate);Helmirazine (citrate);Helmitin;Helmizin;Herb royal round worm treatment;Hexanthelin;Ismiverm;Janes liquid permifu;Jarabe neox;Jetsan supp. (adipate);Justalmin;Kennel-maid;Kihomato;Kontipar;Lamboxil;Lombricida tropico;Lombrifher;Lombrikal;Lombrimade;Mapiprin;Maskito;Noxiurotan;Ogen;Okuside;Optiverm;Oxiril syrup (hydrate);Oxiuran (hydrate);Oxiurasin;Oxiustip elix;Oxivermin;Oxizin;Oxucid;Oxuril;Oxypip;Oxyzin;P.c. (citrate);Padrax;Paravermin;Pariamate;Par-tega;Perin;Piavermit;Pincide;Pipan;Pip-a-ray;Pipenin;Piperacid;Piperamicin;Piperascat;Piperaskat;Piperate;Piperaverm;Piperazinal;Piperazine (adipate);Pipercrean;Piperex;Piperiod;Piperital od;Piperitol;Piper-jodina;Piperol fort;Piperone;Piperoverm;Pipertox;Piperver;Piperzinal;Pipeverm;Pipezol;Pipizan citrate;Pipracid;Piprazid;Piprazyl;Pipricide;Piptelate;Piverma;Polo-verm;Polyquil;Pripsen;Provtovermil;Razinol;Rondelim;Rondoxyl;Santoban;Siropar;Supraverm;Taenifigin;Teniver;Tivazine;Toxocan;Uricida;Uridina;Uroclear (hexamine);Urodan (phosphate);Urosolvina;Uvilon syrup (hydrate);Vanpar (hydrate);Veripar;Vermazine;Vermenter;Vermicompren;Vermidol;Vermifug;Vermilass;Vermipan;Vermiphsarmette;Vermiquimpe;Vermiquimyc;Vermisit;Vermitox;Vermofrik;Verocid;Wairmex;Wurmex;Wurmsirup siegfried Multifuge;Multifuj;Nea-vermiol;Nemafugan;Nemasin;Nematocton;Nematorazine;Neo-ifusa;.

世界保健機関(WHO)

Piperazine was first used as a treatment for gout earlier this century and its anthelminthic activity was discovered in 1949. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworm it has been withdrawn from use on the grounds that other more effective and less toxic drugs are now available (see full list). In other such countries, however, piperazine remains available in over-the-counter preparations. Clinical dosages occasionally induce transient neurological signs and concern has been expressed that in some circumstances the drug may generate small amounts of nitrosamine in the stomach. However, it is widely considered that these trace doses are unlikely to give rise to a significant carcinogenic potential. (Reference: (WHODIB) WHO Drug Information Bulletin, 1: 5, , 1983)

一般的な説明

Needle-like white or colorless crystals. Shipped as a solid or suspended in a liquid medium. Very corrosive to skin, eyes and mucous membranes. Solid turns dark when exposed to light. Flash point 190°F. Used as a corrosion inhibitor and as an insecticide.

空気と水の反応

Flammable. Absorbs water and carbon dioxide from air. Soluble in water.

反応プロフィール

1,4-Diazacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. 1,4-Diazacyclohexane is sensitive to light; 1,4-Diazacyclohexane absorbs water and carbon dioxide from air. 1,4-Diazacyclohexane may be corrosive to aluminum, magnesium and zinc. .

健康ハザード

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

健康ハザード

Piperazine is a corrosive substance. The solidand its concentrated aqueous solutions areirritants to the skin and eyes. The irritanteffect in rabbits’ eyes was severe.
The toxic symptoms from ingestion ofpiperazine include nausea, vomiting, excitement,change in motor activity, somnolence,and muscle contraction. The toxicity of thiscompound is low, however. The oral LD50value in rats is 1900 mg/kg. The inhalationtoxicity is very low. The inhalation LC50value in mice is 5400 mg/m3/2 h.

火災危険

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

応用例(製薬)

A synthetic chemical, most commonly formulated as the citrate, but also available as the adipate, edetate calcium and tartrate salts.

接触アレルゲン

Piperazine is contained in pyrazinobutazone, an equimolar salt of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory workers, in nurses, and in veterinarians.

薬物動態学

Activity against intestinal worms requires that a substantial amount remains in the gut. However, after oral administration a variable amount is rapidly absorbed from the small intestine and subsequently excreted in the urine. Its half-life is extremely variable.

臨床応用

Hexahydropyrazine or diethylenediamine (Arthriticine,Dispermin) occurs as colorless, volatile crystals of the hexahydratethat are freely soluble in water. After the discoveryof the anthelmintic properties of a derivative diethylcarbamazine,the activity of piperazine itself was established.Piperazine is still used as an anthelmintic for the treatmentof pinworm (Enterobius [Oxyuris] vermicularis) and roundworm(Ascaris lumbricoides) infestations. It is available invarious salt forms, including the citrate (official in the USP)in syrup and tablet forms. Piperazine blocks the response of the ascaris muscleto acetylcholine, causing flaccid paralysis in the worm,which is dislodged from the intestinal wall and expelled inthe feces.

臨床応用

Ascariasis
Pinworm

副作用

Some people develop hypersensitivity, requiring cessation of treatment. Transient, mild gastrointestinal or neurological symptoms may occur.

安全性プロファイル

Moderately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Excessive absorption can cause urticaria, vomiting, diarrhea, blurred vision, and weakness. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Explodes on contact with dicyanofurazan. To fight fire, use alcohol foam, mist, dry chemical, water spray. When heated to decomposition it emits highly toxic fumes of NOx.

職業ばく露

(Piperazine): Primary irritant (w/o allergic reaction),

Veterinary Drugs and Treatments

Piperazine is used for the treatment of ascarids in dogs, cats, horses, swine and poultry. Piperazine is considered safe to use in animals with concurrent gastroenteritis and during pregnancy.

Carcinogenicity

No increase in lung adenomas was produced in mice administered 0.69–18.75mg of piperazine/ kg in drinking water for 20–25 weeks and sacrificed 10–13 weeks later. Mice fed the equivalent of 938 mg/kg in the diet for 28 weeks and sacrificed at 40 weeks failed to show any significant increase in the incidence of lung adenomas. An increase in lung adenomas was produced in this bioassay by administration of piperazine together with sodium nitrate, suggesting the formation of the active nitroso derivative. Sodium ascorbate inhibited tumor formation, in theory, by preventing piperazine nitrosation (304). Coadministration of 250 ppm piperazine and 500 ppm sodium nitrate in drinking water did not produce tumors in rats. None of these studies were conducted using currently accepted methods for evaluating carcinogenic potential but piperazine alone, in these assays, was noncarcinogenic.

輸送方法

UN2579 Piperazine, Hazard class: 8; Labels: 8-Corrosive material.

純化方法

Piperazine crystallises from EtOH or anhydrous *benzene and is dried at 0.01mm. It can be sublimed under vacuum and purified by zone melting. The hydrochloride has m 172-174o (from EtOH), and the dihydrochloride crystallises from aqueous EtOH and has m 318-320o (dec, sublimes at 295-315o). The picrate has m ~200o, and the picrolonate crystallises from dimethylformamide ( m 259-261o). [Beilstein 23 H 4, 23 I 4, 23 II 3, 23 III/IV 15, 23/1 V 30.]

不和合性

Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.

ピペラジン (無水) 上流と下流の製品情報

原材料

準備製品

ジプラシドン塩酸塩一水和物 1,4-ビス(2,2,2-トリクロロ-1-ホルミルアミノエチル)ピペラジン 1-(2-シアノエチル)ピペラジン 1-[3-(トリフルオロメチル)ピリド-2-イル]ピペラジン 1-(2-クロロベンジル)ピペラジン テラゾシン 1-(3-メチルピリジン-2-イル)ピペラジン 塩酸フルナリジン 4-アミノ-3-ヒドラジノ-5-メルカプト-1,2,4-トリアゾール 1-(シクロヘキシルカルボニル)ピペラジン くえん酸ピペラジン水和物 4-(3-クロロプロピル)-1-ピペラジンエタノール 1-(2-クロロ-6-フルオロベンジル)ピペラジン 1-[(4-ピリジル)メチル]ピペラジン 1-(3-ニトロピリジン-2-イル)ピペラジン 1-(3-クロロベンジル)ピペラジン 1-ピペラジンカルボン酸tert-ブチル 4-(1-ピペラジニル)ベンゾニトリル アモキサピン ピペラジン-1-カルボン酸ジメチルアミド 1-(3-メトキシプロピル)ピペラジン セフブペラゾン N,N-ジメチル-2-ピペラジン-1-イル-アセトアミド サラフロキサシン 1,4-ジホルミルピペラジン 1,4-ビス(3-アミノプロピル)ピペラジン 1-ブチルピペラジン 1-(3-フェニル-2-プロペニル)ピペラジン ベスナリノン クロペンチキソール 1-(1-メチル-4-ピペリジル)ピペラジン 1-(3-ジメチルアミノプロピル)ピペラジン 1-カルボベンゾキシピペラジン 1-〔5-(トリフルオロメチル)-2-ピリジニル〕ピペラジン 4,4'-[1,3-プロパンジイルビス(4,1-ピペラジンジイル)]ビス(7-クロロキノリン)

ピペラジン (無水) 生産企業

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110-85-0(ピペラジン (無水))キーワード:


  • 110-85-0
  • PIPERAZINE
  • 1,4-DIAZACYCLOHEXANE
  • AKOS 90646
  • AKOS BBS-00004315
  • HEXAHYDRO-1,4-DIAZINE
  • HEXAHYDROPYRAZINE
  • DIETHYLENEDIAMINE
  • Anhydrous Piperazine (PIP)
  • PIPERAZINE ANHYDROUS-FLAKES
  • PIPERAZINE REAGENTPLUS(TM) 99%
  • PIPERAZINE, REAGENTPLUS, 99%
  • PiperazineHydrateBp
  • Diethylenediamine (non-medicinal)
  • Piperazidine (non-medicinal)
  • Piperazine (non-medicinal)
  • Piperazine, extra pure, 99%
  • DIETHYLDIAMINE
  • Anhydrous ether
  • Piperazine Hexahydrtae
  • PIPRAZINE ANHYDROUS pure
  • Diethylene diamine anhydrous
  • 1,4-Diazacyclohexane, Diethylenediamine
  • PiperazineAnhydrous, ≥ 99.7% (GC)
  • Piperazine (anhydrous) Msynthplus
  • piperazine,anhydrous
  • Pipersol
  • Pyrazine hexahydride
  • Pyrazine, hexahydro-
  • pyrazinehexahydride
  • Upixon
  • ピペラジン (無水)
  • ピペラジン
  • ジスペルミン
  • アンチレン
  • ヘキサヒドロピラジン
  • ルンブリカル
  • ジエチレンジアミン
  • ピペラジジン
  • ジエチレンアミン
  • ピペラジン(無水)
  • ピペラジン標準品
  • ピペラジン,無水
  • ピペラジン, 無水
  • ピペラジン, 無水, 99%
  • 代謝産物
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