4-アミノフェノール

4-アミノフェノール 化学構造式
123-30-8
CAS番号.
123-30-8
化学名:
4-アミノフェノール
别名:
4-アミノフェノール;ウルソールP;アゾール;パラノール;ベンゾフルP;C.I.オキシデーションベース6;ウナール;アクチボール;p-アミノフェノール;ロジナール;ウルソールPベース;ペラゴールPベース;ペラゴールグレーPベース;4-ヒドロキシアニリン;セルチナール;p-ヒドロキシアニリン;シトール;パラ-アミノフェノール;p-アミノフェノル;pアミノフェノール
英語名:
4-Aminophenol
英語别名:
P-AMINOPHENOL;PARA AMINO PHENOL;aminophenol;AZOL;PARANOL;Energol;JAROCOL PAP;CAS:123-30-8;AMINOPHENOL-4;phenol,4-amino-
CBNumber:
CB5852965
化学式:
C6H7NO
分子量:
109.13
MOL File:
123-30-8.mol
MSDS File:
SDS

4-アミノフェノール 物理性質

融点 :
188 °C
沸点 :
284 °C
比重(密度) :
1.29
蒸気圧:
0.4 hPa (110 °C)
屈折率 :
1.5444 (estimate)
闪点 :
189 °C
貯蔵温度 :
2-8°C
溶解性:
水: わずかに溶ける
外見 :
結晶性粉末
酸解離定数(Pka):
5.48, 10.30(at 25℃)
色:
ホワイト~クリーム
水溶解度 :
1.5g/100mL(20℃)
Sensitive :
Air & Light Sensitive
Decomposition :
284 °C
Merck :
14,462
BRN :
385836
安定性::
安定ですが、空気中で変色することがあります。酸、クロロホルメート、強力な酸化剤とは相容れない。
InChIKey:
PLIKAWJENQZMHA-UHFFFAOYSA-N
LogP:
-0.09-0.04 at 25℃
CAS データベース:
123-30-8(CAS DataBase Reference)
NISTの化学物質情報:
Phenol, 4-amino-(123-30-8)
EPAの化学物質情報:
p-Aminophenol (123-30-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,N
Rフレーズ  20/22-50/53-68-40-R68-R50/53-R20/22
Sフレーズ  28-36/37-60-61-28A-S61-S60-S36/37-S28A
RIDADR  UN 2512 6.1/PG 3
WGK Germany  3
RTECS 番号 SJ5075000
8
自然発火温度 >250 °C
TSCA  Yes
国連危険物分類  6.1
容器等級  III
HSコード  28402090
HSコード  29222900
有毒物質データの 123-30-8(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 375 mg/kg LD50 dermal Rabbit > 10000 mg/kg
化審法 (3)-675
安衛法 変異原性物質
PRTR法 第一種指定化学物質
環境リスク評価 p-アミノフェノール(123-30-8)
絵表示(GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
注意喚起語 警告
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H341 遺伝性疾患のおそれの疑い 生殖細胞変異原性 2 警告 P201,P202, P281, P308+P313, P405,P501
H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 GHS hazard pictograms P273, P391, P501
注意書き
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P312 飲み込んだ場合:気分が悪い時は医師に連絡する こと。
P302+P352 皮膚に付着した場合:多量の水と石鹸で洗うこと。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。

4-アミノフェノール 価格 もっと(30)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0101-0269 p-アミノフェノール 98.0+% (HPLC)
p-Aminophenol 98.0+% (HPLC)
123-30-8 25g ¥3250 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01W0101-0269 p-アミノフェノール 98.0+% (HPLC)
p-Aminophenol 98.0+% (HPLC)
123-30-8 500g ¥11300 2024-03-01 購入
東京化成工業 A0384 4-アミノフェノール >98.0%(GC)(T)
4-Aminophenol >98.0%(GC)(T)
123-30-8 25g ¥2100 2024-03-01 購入
東京化成工業 A0384 4-アミノフェノール >98.0%(GC)(T)
4-Aminophenol >98.0%(GC)(T)
123-30-8 500g ¥11300 2024-03-01 購入
関東化学株式会社(KANTO) 01245-31 p‐アミノフェノール >97.0%(T)
p‐Aminophenol >97.0%(T)
123-30-8 25g ¥2500 2024-03-01 購入

4-アミノフェノール MSDS


4-Aminophenol

4-アミノフェノール 化学特性,用途語,生産方法

外観

白色~紫色又は褐色、結晶~結晶性粉末

溶解性

冷水に微溶 (1.11g/100ml水, 0℃)。アルコールに可溶。エタノールにやや溶けやすく、水にやや溶けにくい。

用途

硫化染料中間体、ゴム老化防止剤、写真現像薬原料

用途

有機合成原料(医薬、染料)、写真用薬品。

使用上の注意

不活性ガス封入

説明

4-Aminophenol, also known as 4-hydroxyaniline, is an organic building block. Its quantification in water samples upto the detection limit of 8×10-10mol l-1 has been proposed by employing single-wall carbon nanotubes (SWNT)-nafion film coated glassy carbon electrodes. It is present as the main contaminant in pharmaceutical formulations of paracetamol. High-performance liquid chromatographic (HPLC) method with amperometric detection has been reported for its determination in various analgesic formulations. It has been reported to be formed from the reduction of 4-nitrophenol (Nip) under metal-free conditions catalyzed by N-doped graphene (NG).

化学的特性

o-Aminophenol appears as colorless needles or as white crystalline substance turning tan to brown on exposure to air. slightly soluble in water and ethanol, insoluble in benzene and chloroform, and quickly turns brown when dissolved in lye.

使用

4-Aminophenol is suitable for use in the synthesis of 2,2-bis(4-aminophenoxy) benzonitrile [4-APBN], a monomer required for the preparation of series of polyamides and poly(amide-imide)s. It may be used as derivatization reagent to improve the ionization of aliphatic and aromatic aldehydes by paper spray ionization mass spectrometry.

製造方法

Conventionally 4-aminophenol was manufactured using iron-acid reduction of p-nitrobenzene. Reduction using iron-acid is a multi-step process. The modern method is the catalytic dehydrogenation of nitrobenzene to 4-aminophenol using a noble metal catalyst in the presence of an acidic medium. This method also produces aniline as a side-product. The advantage of a reduction using a noble metal catalyst is that it involves a single step reaction, an environment friendly and more efficient process, as there is no evolution of an environmentally harmful gas. Moreover, the side-product aniline is also a valuable chemical.
synthesis of 4-aminophenol
synthesis of 4-aminophenol

主な応用

The main and the most significant use of 4-Aminophenol is for the manufacturing of Paracetamol, an analgesic and antipyretic drug. In addition to paracetamol, it is a key element in the synthesis of pharmaceutical ingredients and important industrial chemicals like Acebutolol, Ambroxol, Sorafenib and so on.
4-Aminophenol is used as a dye for textiles, hair, furs and feathers, and is also used as a developing agent in photography for creating black and white images. It acts as a corrosion inhibitor in paints and as anti-corrosive lubricating agent in 2-cycle engines. It is also used as a wood stain, giving rose-like colour to timber. p-Aminophenol is one of key ingredients for synthesis of rubber antioxidants. Moreover, it is often used as a reagent for analysing metals like Copper, Magnesium, Vanadium and Gold, compounds like Nitrites and Cyanates, and antioxidants.

定義

ChEBI: 4-aminophenol is an amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group. It has a role as a metabolite and an allergen.

一般的な説明

P-aminophenol appears as white or reddish-yellow crystals or light brown powder. Turns violet when exposed to light. (NTP, 1992)

空気と水の反応

Insoluble in water.

反応プロフィール

Heat (decomposition forming HCN, nitrous vapors, CO); water (CO2); reacts violently with acids, bases, alcohols and amines causing fire and explosion hazards [Handling Chemicals Safely 1980 p. 647].

健康ハザード

p-Aminophenol is of moderately low toxicity but has caused dermal sensitization and kidney injury; the potential for producing methemoglobin is of relatively minor importance.
The oral LD50 in rats was 671 mg/kg.1 Effects included central nervous system depression. A solution of 2.5% applied to abraded skin of rabbits was a mild irritant.1 p- Aminophenol caused dermal sensitization in guinea pigs, and skin sensitization has been reported in humans.2,3 The dermal LD50 in rabbits was greater than 8 g/kg, which strongly suggests that absorption through the skin is minimal.4 Single nonlethal acute doses in rats produced proximal renal tubular necrosis of the pars recta.

火災危険

Flash point data are not available for 4-Aminophenol. 4-Aminophenol is probably combustible.

接触アレルゲン

This hair dye is frequently implicated in contact dermatitis in hairdressers, customers, or people sensitized to para-phenylenediamine, by the way of “blackhenna” temporary tattoos.

安全性プロファイル

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. An allergen and skin and eye irritant. Mutation data reported. Can cause contact dermatitis, bronchial asthma, and methemoglobinemia with cyanosis. When heated to decomposition it emits toxic fumes of NOx,.

職業ばく露

Workers may be exposed to oAminophenol during its use as a chemical intermediate; in the manufacture of azo and sulfur dyes; and in the photographic industry. There is potential for consumer exposure to o-Aminophenol because of its use in dyeing hair, fur, and leather. The compound is a constituent of 75 registered cosmetic products suggesting the potential for widespread consumer exposure. p-Aminophenol is used mainly as a dye, dye intermediate and as a photographic developer; and in small quantities in analgesic drug preparation. Consumer exposure to p-aminophenol may occur from use as a hairdye or as a component in cosmetic preparations. m-Aminophenol is used mainly as a dye intermediate.

Solubility in organics

Very soluble in dimethylsulfoxide Soluble in acetonitrile, ethyl acetate, and acetone Slightly soluble in toluene, diethyl ether, and ethanol Negligible solubility in benzene and chloroform

輸送方法

UN2512 Aminophenols (o-; m-; p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials

純化方法

Crystallise it from EtOH, then water, excluding oxygen. It sublimes at 110o/0.3mm. It has been purified by chromatography on alumina with a 1:4 (v/v) mixture of absolute EtOH/*benzene as eluent. [Beilstein 13 IV 1014.]

不和合性

These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as alkali metals, hydrides, nitrides, and sulfides. Flammable gas (H2) may be generated, and the heat of the reaction may cause the gas to ignite and explode. Heat may be generated by the acidbase reaction with bases; such heating may initiate polymerization of the organic compound. Reacts with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock.

廃棄物の処理

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

4-アミノフェノール 上流と下流の製品情報

原材料

準備製品


4-アミノフェノール 生産企業

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123-30-8(4-アミノフェノール)キーワード:


  • 123-30-8
  • HYDROCODONE/APAP BITARTRATE IMP K
  • CERTINAL
  • CITOL
  • P-HYDROXYANILINE
  • p-Aminophenc
  • p-Aminophenol ;4-Amino-1-hydroxybenzene
  • LABOTEST-BB LTBB000486
  • p-Aminophenol 4-Aminophenol
  • 4-AMINOPHENOL TECH. 95%
  • 4-AMINOPHENOL PESTANAL
  • Rodol P Base
  • O-Aminophenol,>96%
  • 4-Aminophenol99%
  • 4-AMINOPHENOL (p-Aminophenol)
  • 4-AMINOPHENOL, 98+%
  • 4-AMINOPHENOL / 4-HYDROXYANILINE
  • 4-AMinophenol >=99% (HPLC)
  • 4-Aminophenol (Acetaminophen RCK)
  • p-Aminophenol
  • basfursolpbase
  • Benzofur P
  • benzofurp
  • C.I. 76550
  • C.I. Oxidation Base 6
  • C.I. Oxidation Base 6a
  • c.i.76550
  • c.i.oxidationbase6a
  • ci76550
  • nakobrownr
  • p-Aminofenol
  • 4-アミノフェノール
  • ウルソールP
  • アゾール
  • パラノール
  • ベンゾフルP
  • C.I.オキシデーションベース6
  • ウナール
  • アクチボール
  • p-アミノフェノール
  • ロジナール
  • ウルソールPベース
  • ペラゴールPベース
  • ペラゴールグレーPベース
  • 4-ヒドロキシアニリン
  • セルチナール
  • p-ヒドロキシアニリン
  • シトール
  • パラ-アミノフェノール
  • p-アミノフェノル
  • pアミノフェノール
  • pアミノフェノル
  • P‐アミノフェノール
  • 4-アミノフェノール, 98%
  • アニリン (液晶原料)
  • フェノール (液晶原料)
  • 二官能性液晶原料
  • 機能性材料
  • 液晶原料
  • 代謝産物
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