バレニクリン

バレニクリン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

バレニクリン 化学特性,用途語,生産方法

効能

禁煙補助薬, ニコチン性アセチルコリン受容体部分作動薬

説明

Varenicline, a partial agonist of the a4b2 nicotinic receptor, is a first-in-class drug launched by Pfizer as an aid to smoking cessation treatment. Varenicline exhibits dual action by decreasing craving and withdrawal symptoms, and by decreasing the reinforcement associated with smoking. The addictive properties of nicotine are thought to be mediated in part through its action as an agonist at α4β2 neuronal nicotinic acetylcholine receptors (nAChRs). Activation of α4β2 receptors by nicotine increases the release of dopamine in the mesolimbic system, an effect that is shared by most drugs of abuse. As nicotine levels decrease, dopamine levels decline, which in turn stimulates the urge to smoke. Additionally, a reduced dopaminergic tone due to abstinence from smoking stimulates craving and the withdrawal syndrome. A partial agonist of α4β2 receptors such as varenicline is expected to elicit a moderate and sustained increase in dopamine levels to relieve craving and withdrawal symptoms. In addition, by competitively binding to a4b2 receptors and inhibiting nicotineinduced dopaminergic activation, a partial agonist could attenuate the pharmacologic reward associated with smoking.

使用

Varenicline is a useful medication for smoking cessation.

定義

ChEBI: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.

バレニクリン 上流と下流の製品情報

原材料

準備製品

バレニクリン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Casorganics US Corp	+17326109938	sales@casorganics.com	CHINA	174	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58

249296-44-4(バレニクリン)キーワード:

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• 249296-44-4
• 3-h][3]benzazepine
• Varenicline Impurity
• VARENICLINE
• 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine
• Vareniclene
• Varenicline free base
• Cp 526555
• Hsdb 7591
• Unii-W6hs99o8zo
• 10-Methano-6H-pyrazino[2
• 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-
• CS-861
• CP 526555;CHAMPIX;CHANTIX;CP526555;CP-526555
• Varenicline base
• Varenicline (CP 526555)
• Varenicline 13C15N
• (1R,12S)-5,8,14-triazatetracyclo[10.3.1.0^{2,11}.0^{4,9}]hexadeca-2,4(9),5,7,10-pentaene
• 10-tetrahydro-
• 7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline
• Chantix
• Varenciline
• VERENICLINE
• Vancomycin Impurity 20
• 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (Vareniclene)
• バレニクリン
• 7,8,9,10-テトラヒドロ-6α,10α-メタノ-1,4,8-トリアザ-6H-シクロヘプタ[b]ナフタレン
• (1R,12S)-5,8,14-トリアザテトラシクロ[10.3.1.02,11.04,9]ヘキサデカ-2(11),3,5,7,9-ペンタエン