ChemicalBook
Chinese english Germany Korea

L-プロリン

L-プロリン 化学構造式
147-85-3
CAS番号.
147-85-3
化学名:
L-プロリン
别名:
L-プロリン;プロリン;L(-)-プロリン;L-2-ピロリジンカルボン酸;L(-)‐プロリン;L‐プロリン;L‐プロリン CRM6016‐A;L-プロリン-D7;プロリン, L-;L-プロリン (JP17);プロリン 1;プロリン 2
英語化学名:
L-Proline
英語别名:
PRO;L-PRO;ccc(u);cb1707;l-prolin;L-Poline;H-PRO-OH;L-Pro-OH;NSC 46703;FEMA 3319
CBNumber:
CB6118196
化学式:
C5H9NO2
分子量:
115.13
MOL File:
147-85-3.mol

L-プロリン 物理性質

融点 :
228 °C (dec.)(lit.)
比旋光度 :
-85.5 º (c=4, H2O)
沸点 :
215.41°C (rough estimate)
比重(密度) :
1.35
屈折率 :
-85 ° (C=4, H2O)
FEMA :
3319 | L-PROLINE
貯蔵温度 :
Store at RT.
溶解性:
H2O: 50 mg/mL
外見 :
powder
酸解離定数(Pka):
1.95, 10.64(at 25℃)
色:
White
PH:
6.0-7.0 (25℃, 1M in H2O)
光学活性 (optical activity):
[α]20/D 85.0±1.0°, c = 5% in H2O
水溶解度 :
soluble
Sensitive :
Hygroscopic
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number:
1425
Merck :
14,7780
BRN :
80810
安定性::
Stable. Incompatible with strong oxidizing agents.
CAS データベース:
147-85-3(CAS DataBase Reference)
NISTの化学物質情報:
Proline(147-85-3)
EPAの化学物質情報:
L-Proline(147-85-3)

安全性情報

主な危険性  Xi,Xn
Rフレーズ  36/37/38-22
Sフレーズ  24/25-36/37/39-26
WGK Germany  3
RTECS 番号 TW3584000
3-10
TSCA  Yes
HSコード  29339990
有毒物質データの 147-85-3(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: > 5110 mg/kg
化審法 (9)-1626 届出不要化学物質

L-プロリン 価格 もっと(65)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00016256 プロリン, L-
Proline, L-
147-85-3 100mg ¥26600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01OCLDLM-487 L-プロリン-d7
L-Proline-d7
147-85-3 0.1g ¥161000 2018-12-26 購入
東京化成工業 P0481 L-プロリン >99.0%(HPLC)(T)
L-Proline >99.0%(HPLC)(T)
147-85-3 250g ¥24700 2018-12-04 購入
東京化成工業 P0481 L-プロリン >99.0%(HPLC)(T)
L-Proline >99.0%(HPLC)(T)
147-85-3 25g ¥4700 2018-12-04 購入
関東化学株式会社(KANTO) 15762-1A L(-)‐プロリン >99.0%
L(-)‐Proline >99.0%
147-85-3 25g ¥4000 2018-12-13 購入

L-プロリン MSDS


2-Pyrrolidinecarboxylic acid

L-プロリン 化学特性,用途語,生産方法

定義

本品は、次の化学式で表されるアミノ酸である。

化粧品の成分用途

ヘアコンディショニング剤、皮膚コンディショニング剤

効能

プロリン補充薬

化学的特性

L-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste.

化学的特性

White crystalline powder

天然物の起源

Reported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue.

使用

amino acid, nutrient

使用

L-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.

製造方法

From α-piperidone; from cyclopentantone; from l-glutamic acid.

酵素阻害剤

This pyrrolidine (FW = 115.13 g/mol; pK1 = 1.95; pK2 = 10.64), symbolized as eithet Pro or P, is one of the twenty proteogenic amino acids. Its fivemembered ring is usually puckered, with the g carbon (position C4 of the ring) out of the plane by about 0.5 ?.There are six codons that code for Lproline: CCC, CCU, CCA, and CCG. This amino acid is unique among the twenty proteogenic amino acids in that the “side chain” is covalently linked to the nitrogen. Proline is regarded as a nonpolar amino acid; interestingly, however, most prolyl residue in proteins are located on the surface of proteins, since the steric constraints of the pyrrolidine ring results in reverse turns. Such constraints make prolyl residues incompatible with a-helical structures and b-pleated sheets. Even so, prolyl residues can be found at Ntermini of a-helices. In addition, prolyl residues can be found in long helices; the residue cause a small distortion of the helical structure. Prolyl residues are also abundant and structural important in the collagen triple helix. In homologous proteins, if a prolyl residue is interchanged, it is usually with either an alanyl or a seryl residue. The L-stereoisomer has a specific rotation of –60.4° at 25°C of the D line for a 1.0–2.0 g/100 mL solution in 5 M HCl (–86.2° in distilled water). It is soluble in water (162.3 g/100 mL at 25°C; 206.7 g/100 mL at 50°C; and 239 g/100 mL at 65 °C) and is one of the few common amino acids that is soluble in ethanol (67 g/100 mL at 19°C). It is insoluble in diethyl ether, butanol, and isopropanol. While the proline “side chain” is relatively inert, prolyl residues in certain proteins, including collagen, undergo enzyme-catalyzed hydroxylation reactions at the C3 or C4 positions. Free proline also react swith periodate to produce 2-pyrrolidone. A number of enzymes use D- or L-proline as an alternative substrate (and competitive inhibitor). These include the aminoacid dehydrogenase, the amino acid oxidases, alanine:oxo-acid aminotransferase, ornithine:oxo-acid aminotransferase, asparagine:oxo-acid aminotransferase, and amino-acid racemase. Target(s): acetylcholinesterase, weakly inhibited; 2-aminohexano-6-lactam racemase, weakly inhibited; arginase, weakly inhibited; arginine deiminase; aspartate aminotransferase; [citrate lyase] deacetylase, weakly inhibited; CTP synthetase, weakly inhibited; cysteinyl-tRNA synthetase activity of Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase; glutamine synthetase, weakly inhibited; γ-glutamyl kinase, or glutamate 5-kinase; glycine/sarcosine Nmethyltransferase; hydroxy-L-proline oxidase; membrane alanyl aminopeptidase, or aminopeptidase N; phosphorylase kinase; polar-amino-acid-transporting ATPase, histidine permease, also alternative substrate; pyrroline-5-carboxylate dehydrogenase; 1-pyrroline- 5-carboxylate reductase; pyruvate kinase; a,a-trehalose-phosphate synthase, or UDP-forming; and Xaa-Pro dipeptidase, or prolidase, or imidodipeptidase.

純化方法

A likely impurity is hydroxyproline. Purify L-proline via its picrate which is crystallised twice from water, then decomposed with 40% H2SO4. The picric acid is extracted with diethyl ether, the H2SO4 in solution is precipitated with Ba(OH)2, and the filtrate is evaporated. The residue is crystallised from hot absolute EtOH [Mellan & Hoover J Am Chem Soc 73 3879 1951] or EtOH/Et2O. Its solubility in H2O is >100%. It sublimes at 182-187o/0.3mm with 99.4% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. It is hygroscopic and is stored in a desiccator. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2178-2199 1961, Beilstein 22 III/IV 8, 22/1 V 31.]

L-プロリン 上流と下流の製品情報

原材料

準備製品


L-プロリン 生産企業

Global( 551)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21910 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1752 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20642 58

147-85-3(L-プロリン)キーワード:


  • 147-85-3
  • L-Poline
  • ccc(u)
  • femanumber3319
  • L(-)-Prolin
  • l-alpha-pyrrolidinecarboxylicacid
  • l-prolin
  • pro(iupacabbreviation)
  • L-PROLINE extrapure CHR
  • PROLINE, DL-(RG)
  • L-PROLINERESEARCH GRADE
  • L-Proline,(S)-Pyrrolidine-2-carboxylic acid
  • L-Proline, extra pure, Ph Eur, USP, BP, NF
  • L-Proline (200 mg)
  • L-Proline (200 mg)G0D1461.00mg/mg(dr)
  • L-PROLINE, U.S.P.
  • 2-Pyrrolidinecarboxy
  • L(-)-Proline, 99+% 100GR
  • L(-)-Proline, 99+% 25GR
  • L(-)-Proline, 99+% 5GR
  • (S)-(-)-PROLINE FOR SYNTHESIS
  • Proline (P)
  • Proline Solution (P)
  • NSC 46703
  • (2S)-Pyrrolidin-2-carbonsαure
  • (s)-2-pyrrolidinecarboxylicaci
  • (s)-2-pyrrolidinecarboxylicacid
  • (S)-Prolin
  • 2-Pyrrolidinecarboxylic acid, (S)-
  • cb1707
  • 2-pyrrolidinecarboxylic acid
  • L-プロリン
  • プロリン
  • L(-)-プロリン
  • L-2-ピロリジンカルボン酸
  • L(-)‐プロリン
  • L‐プロリン
  • L‐プロリン CRM6016‐A
  • L-プロリン-D7
  • プロリン, L-
  • L-プロリン (JP17)
  • プロリン 1
  • プロリン 2
  • α-アミノ酸
  • アミノ酸
  • プロリンと類似体
  • 不斉合成
  • 不斉有機触媒
  • 生化学
  • 有機合成化学
Copyright 2017 © ChemicalBook. All rights reserved