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ビタミンB12

ビタミンB12 化学構造式
68-19-9
CAS番号.
68-19-9
化学名:
ビタミンB12
别名:
ビタミンB12;シアノコバラミン;ビタミンB12標準品;シアノコバラミン標準品;ビタミン B12(シアノコバラミン);ビタミン B12;シアノコバラミン (JP17)
英語化学名:
Vitamin B12
英語别名:
Vb12;cotel;covit;Bedoz;vibalt;vitral;cn-b12;cyomin;embiol;CN-CBL
CBNumber:
CB6126463
化学式:
C63H88CoN14O14P
分子量:
1355.37
MOL File:
68-19-9.mol

ビタミンB12 物理性質

融点 :
>300°C
沸点 :
>300 °C
比旋光度 :
23656 -59 ± 9° (dil aq soln)
闪点 :
9℃
貯蔵温度 :
2-8°C
溶解性:
Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic.
外見 :
Crystalline Powder or Crystals
酸解離定数(Pka):
pKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain)
色:
Red to dark red
水溶解度 :
Soluble
Sensitive :
Hygroscopic
Merck :
14,10014
BRN :
4122889
安定性::
Hygroscopic. Keep cold and dry.
InChIKey:
RMRCNWBMXRMIRW-WZHZPDAFSA-L
EPAの化学物質情報:
Vitamin B12 (68-19-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性 
有毒物質データの 68-19-9(Hazardous Substances Data)
毒性 LD50 intravenous in mouse: 2gm/kg
安衛法 57,57-2
PRTR法 第一種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P311 医師に連絡すること。

ビタミンB12 価格 もっと(38)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSVIT-010N-R1 ビタミンB12
Vitamin B12
68-19-9 25mg ¥7400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01LKTV3378 ビタミンB12
Vitamin B12
68-19-9 500mg ¥15100 2021-03-23 購入
東京化成工業 C0449 ビタミンB12 >95.0%(E)
Vitamin B12 >95.0%(E)
68-19-9 100mg ¥2100 2021-03-23 購入
東京化成工業 C0449 ビタミンB12 >95.0%(E)
Vitamin B12 >95.0%(E)
68-19-9 1g ¥7800 2021-03-23 購入
関東化学株式会社(KANTO) 08185-96 シアノコバラミン標準品 >96.0%(HLC)
Cyanocobalamin standard >96.0%(HLC)
68-19-9 100mg ¥7500 2021-03-23 購入

ビタミンB12 化学特性,用途語,生産方法

外観

赤色~暗い赤色~濃い紫色粉末~結晶

定義

本品は、ビタミンB12であり、次の化学式で表される。

用途

ビタミン B12 化合物です。 メチル基転移反応、カルボキシル基の分子内 転移反応に関与しています。

用途

ビタミン B12 化合物です。メ チル基転移反応、カルボキシル基の分子内転 移反応に関与しています

化粧品の成分用途

皮膚コンディショニング剤

効能

貧血治療薬, 造血薬, ビタミンB12補充薬

商品名

サンコバ (参天製薬); シアノコバラミン (ニプロ); シアノコバラミン (小林化工); シアノコバラミン (日医工); シアノコバラミン (東和薬品); シアノコバラミン (鶴原製薬); ビタミンB12 (キョーリンリメディオ); ビタミンB12 (小林化工)

化学的特性

Dark red, crystalline powder or dark red crystals.

Originator

Berubigen,Upjohn,US,1949

来歴

VITAMIN B12 (Cobalamin), Sometimes also called cyanocobalamin, this vitamin is one of the more recent of the major B complex vitamins to be fully identified, with its structure not definitized (by Hodkin et al.)

使用

vitamin, coenzyme B12

使用

Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the β-ligand of the cobalt are termed cobalamins. Synthesi zed almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.

使用

A coenzyme for synthesis of nucleic acids and metabolism carbohydrates.

使用

Vitamin B12 is water-soluble required for the normal development of red blood cells. Its deficiency causes pernicious anemia. It is stable in neutral conditions and is more stable for storage than for processing conditions. It is found in meat, fish, and milk.

調製方法

Vitamin B12 dietary supplements are often prepared commercially by the fermentation of S. griseus, S. aureofaciens, Propionibacterium; or as a by-product of antibiotic production.

Manufacturing Process

The following is taken from US Patent 3,057,851. Milorganite was extracted with water to obtain an aqueous extract containing vitamin B12 active substances. This aqueous extract was purified by treatment with an ion exchange resin according to the following method. An aqueous extract of milorganite, 100 ml containing 300 μg of vitamin B12 active substances and 4.5 grams of total solids, was combined with 0.5 gram of sodium nitrite and 0.4 gram of potassium cyanide. The resulting solution was adjusted to pH 4.0 with hydrochloric acid and heated to boiling. The boiled solution was filtered through a Super-Cel filter surface, and the filter was then washed with water. The filtrate was obtained in a total volume of 130 ml including the washings. Amerlite XE-97, an ion exchange resin of the carboxyl type (Rohm and Haas), was classified to an average wet particle size of 100 to 150 mesh. The classified resin was utilized in the hydrogen form, and was not buffered during the ion exchange fractionation. The classified resin, in the amount of 35 ml, was packed into a glass column having a diameter of 25 mm and a height of 250 mm. The cyanide-treated aqueous extract of milorganite was infused gravitationally into the ion exchange bed at a rate of 3 ml per minute. The effluent was discarded and the resin bed was then washed with the following solutions in the specified sequence: (1) 120 ml of an aqueous 0.1 N hydrochloric acid solution; (2) 75 ml of an aqueous 85% acetone solution; and (3) 70 ml of an aqueous 0.1 N hydrochloric acid solution. After washing, the resin bed was eluted with an aqueous 60% dioxane solution containing 0.1 N of hydrochloric acid. In this elution, 8 ml of colored eluate was collected. This portion of the eluate was found to contain 295 μg of cyanocobalamin and 9 mg of total solids.

brand name

Nascobal (QOL).

Therapeutic Function

Hematinic

健康ハザード

Deficiency diseases or disorders include retarded growth; pernicious anemia; megaloblastic anemia; macrocytic, hyperchromic anemia; glossitis; spinal cord degeneration; and sprue.

生物活性

Principal physiological functions include: (1) Coenzyme in nucleic acid, protein, and lipid synthesis; (2) maintains growth; (3) participates in methylations; (4) maintains epithelial cells and nervous system (myelin sheath); (5) erythropoiesis (with folic acid); (6) leukopoiesis.

安全性プロファイル

Poison by subcutaneous route. Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of POx and NOx. See also COBALT COMPOUNDS.

Veterinary Drugs and Treatments

Cyanocobalamin is used for treating deficiencies of vitamin B12. Malabsorption of the nutrient secondary to gastrointestinal tract disease, or dietary chromium deficiencies (in ruminants) can be associated with dietary deficiencies of vitamin B12. As there appears to be a high percentage of cats with exocrine pancreatic insufficiency or gastrointestinal disease that are deficient in cobalamin, there is considerable interest in evaluating serum cobalamin (vitamin B12) in these patients. Giant schnauzers may have a genetic defect affecting the location of the cobalamin-intrinsic factor, causing cobalamin deficiency. Dogs with inflammatory bowel disease may also develop cobalamin deficiency.

純化方法

Vitamin B12 crystallises from de-ionized H2O, with a solubility in H2O of 1g/80g, and is dried under vacuum over Mg(ClO4)2. The dry red crystals are hygroscopic and can absorb 12% of 2O. A solution at pH 4.5-5 can be autoclaved for 20minutes at 120o without decomposition. Aqueous solutions are stabilised by addition of (NH4)2SO4. [Golding Comprehensive Organic Chem Vol 5 (Ed. Haslam; Pergamon Press, NY, 1979) pp 549584.] Alternatively an aqueous solution of the coenzyme can be concentrated, if necessary in a vacuum at 25o or less, until the concentration is 0.005 to 0.01M (as estimated by the OD at 522nm of an aliquot diluted with 0.01M K-phosphate buffer pH 7.0). If crystals begin to form on the walls of the container, they should be re-dissolved with a little H2O. The concentrated solution is placed in a glass stoppered flask and diluted with 5volumes of Me2CO. After 2-3hours at 3o it is centrifuged (10,000xg/10minutes) in Me2CO-insoluble plastic tubes to remove some amorphous precipitate. The clear supernatant is inoculated with a small crystal of the vitamin and allowed to crystallise overnight at 3o. Crystals are formed on the walls and the bottom of the container. A further 2volumes of Me2CO are added and set aside at 3o to further crystallise. Crystallisation is followed by observing the OD522 of the supernatant. When the OD falls to 0.27, then ca 94% of the crystals have separated. The supernatant is decanted (saved for obtaining a second crop), and the crystals are washed with a little cold 90% aqueous Me2CO (2x), 100% Me2CO (2x), Et2O (2x) at which time the crystals separate from the glass walls. Allow them to settle and remove residual Et2O with a stream of dry N2. The process can be repeated if necessary. The crystals can be dried in air or in a vacuum for 2hours over silica gel at 100o with an 8-9% weight loss. [Barker et al. Biochemical Preparations 10 33 1963.] This material gives a single spot on paper chromatography [see Weissbach et al. J Biol Chem 235 1462 1960.] The vitamin is soluble in H2O (16.4mM at 24o, 6.4mM at 1o), in EtOH and PhOH but insoluble in Me2CO, Et2O, CH2Cl2 and dioxane. UV: max at 260, 375 and 522nm ( 34.7 x 106, 10.9 x 106 and 8.0 x 106 / mole) in H2O. The dry crystals are stable for months in the dark, but aqueous solutions decompose on exposure to VIS or UV light or alkaline CN-, but are stable in the dark at pH 6-7. The vitamin is inactivated by strong acids or alkalies. [Barker et al. J Biol Chem 235 480 1960, see also Vitamin B12 (Zagalak & Friedrich Eds) Walter de Gruyter, Berlin 1979, Beilstein 2 6 IV 3117.]

ビタミンB12 上流と下流の製品情報

原材料

準備製品


ビタミンB12 生産企業

Global( 553)Suppliers
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68-19-9(ビタミンB12)キーワード:


  • 68-19-9
  • hemomin
  • hepacon-b12
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  • hepavis
  • hepcovite
  • lactobacilluslactisdornerfactor
  • lldfactor
  • macrabin
  • magravon
  • megalovel
  • milbedoce
  • nagravon
  • normocytin
  • pernaemon
  • pernaevit
  • pernipuron
  • plecyamin
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  • rebramin
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  • redisol
  • rhodacryst
  • rubesol
  • rubramin
  • rubraminpc
  • rubripca
  • rubrocitol
  • sytobex
  • terwithcobinamidecyanidehydroxide,innersalt
  • vibalt
  • ビタミンB12
  • シアノコバラミン
  • ビタミンB12標準品
  • シアノコバラミン標準品
  • ビタミン B12(シアノコバラミン)
  • ビタミン B12
  • シアノコバラミン (JP17)
  • ポルフィリン
  • 構造分類
  • 金属別化合物
  • 遷移金属化合物
  • 生化学
  • コバルト化合物
  • ビタミン
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