13-メトキシイボガミン

13-メトキシイボガミン 化学構造式
83-94-3
CAS番号.
83-94-3
化学名:
13-メトキシイボガミン
别名:
タベルナンチン;13-メトキシイボガミン;(1R,15R,17S,18S)-17-エチル-6-メトキシ-3,13-ジアザペンタシクロ[13.3.1.02,10.04,9.013,18]ノナデカ-2(10),4,6,8-テトラエン
英語名:
tabernanthine
英語别名:
tabernanthine;13-Methoxyibogamine;Ibogamine, 13-methoxy-
CBNumber:
CB61350100
化学式:
C20H26N2O
分子量:
310.43
MOL File:
83-94-3.mol

13-メトキシイボガミン 物理性質

融点 :
213.5-215°
比旋光度 :
D20 -40° (acetone)
沸点 :
160 °C
比重(密度) :
1.20±0.1 g/cm3(Predicted)
酸解離定数(Pka):
6.04 in 80% methylcellosolve

安全性情報

13-メトキシイボガミン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

13-メトキシイボガミン 化学特性,用途語,生産方法

説明

An alkaloid which occurs in Tabernanthe iboga BailI. and also in Stem madenia donnell-smithii R. E. Woodson, this base was first given the formula C21H2SON2, later altered to that given above. The alkaloid forms colourless needles or orthorhombic plates from EtOH and is best purified by sublimation. It has [α]D - 35° and gives an ultraviolet spectrum with absorption maxima at 229, 271 and 299 IIlfJ.. The hydrochloride forms colourless crystals from boiling H20, m.p. 275-7°C; [α]25.5D - 66° (MeOH). This salt is freely soluble in CHCI3, contains one methoxyl group and is unsaturated.
When injected intravenously into dogs, the alkaloid is hypotensive, reduces the reflex hypertension induced by occlusion of the carotids, decreases both the rate and amplitude of respiration and, like Ibogaine (q.v.), increases the hypertension produced by injection of adrenaline. It has also been found to prolong the hypotension which results from the injection of acetylcholine.

参考文献

Delourme-Houde., An .. Pharm. Fr., 4, 30 (1946)
Bartlett, Dickel, Taylor.,J. Amer. Chem. Soc., 80, 126 (1958)
Walls, Collera, Sandoval., Tetrahedron, 2, 173 (1958)
Pharmacology: Delourme-Houde., Ann. Pharm. Fr., 4, 30 (1946)

13-メトキシイボガミン 上流と下流の製品情報

原材料

準備製品


13-メトキシイボガミン 生産企業

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83-94-3(13-メトキシイボガミン)キーワード:


  • 83-94-3
  • tabernanthine
  • 13-Methoxyibogamine
  • Ibogamine, 13-methoxy-
  • タベルナンチン
  • 13-メトキシイボガミン
  • (1R,15R,17S,18S)-17-エチル-6-メトキシ-3,13-ジアザペンタシクロ[13.3.1.02,10.04,9.013,18]ノナデカ-2(10),4,6,8-テトラエン
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