シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-]

シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-] 化学構造式
26645-35-2
CAS番号.
26645-35-2
化学名:
シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-]
别名:
ファラシジン;シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-];(2S)-2-[(1S,14R,18S,20S,23S,28S,31S,34R)-28-(2,3-ジヒドロキシ-2-メチルプロピル)-18-ヒドロキシ-23-メチル-15,21,24,26,29,32,35-ヘプタオキソ-31-(プロパン-2-イル)-12-チア-10,16,22,25,27,30,33,36-オクタアザペンタシクロ[12.11.11.03,11.04,9.016,20]ヘキサトリアコンタ-3(11),4,6,8-テトラエン-34-イル]-2-ヒドロキシ酢酸
英語名:
PHALLACIDIN
英語别名:
PHALLICIDIN;PHALLACIDIN;Phallacidin DISCONTINUED;CYCLO(ALA-2-MERCAPTO-TRP-4;phallacidin from amanita phalloides;Cyclo(Ala-2-Mercapto-Trp-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO);-3-hydroxy-d-alpha-aspartyl-l-cysteinyl-cis-4-hydroxy-l-prolyl)cyclic(2-6)-s;cyclic(l-alanyl-2-mercapto-l-tryptophyl-4,5-dihydroxy-l-leucyl-l-valyl-erythro;Cyclo[L-Ala-L-Trp2(1)-4,5-dihydroxy-L-Leu-L-Val-[(3S)-3-hydroxy-D-Asp-]-L-Cys(1)-L-c4Hyp-]
CBNumber:
CB6136097
化学式:
C37H50N8O13S
分子量:
846.9
MOL File:
26645-35-2.mol

シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-] 物理性質

比重(密度) :
1.1678 (rough estimate)
屈折率 :
1.7400 (estimate)
溶解性:
DMF: Soluble; DMSO: Soluble; Methanol: Soluble; Water: Soluble
外見 :
白色からオフホワイトの粉末。

安全性情報

主な危険性  T+
Rフレーズ  26/27/28
Sフレーズ  22-36/37/39-45
RIDADR  1544
WGK Germany  3
RTECS 番号 GT8943000
国連危険物分類  6.1(a)
容器等級  I
HSコード  2934999090

シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-] 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTP2303 ファラシジン
Phallacidin
26645-35-2 1mg ¥112800 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01LKTP2303 ファラシジン
Phallacidin
26645-35-2 5mg ¥402800 2024-03-01 購入
Sigma-Aldrich Japan P8157 ≥85%
Phallacidin from Amanita phalloides ≥85%
26645-35-2 1mg ¥80300 2024-03-01 購入

シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-] 化学特性,用途語,生産方法

説明

Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds filamentous actin (F-actin) like phalloidin , but contains a carboxyl group for coupling reactions.

使用

Toxin Phallacidin is a weak fluorescent bicyclic peptide probe in aquous solution, Which is isolated from Amanita phalloides mushroom and could be used for blocking F-actin staining by labeled phallotoxins, which promotes actin polymerization.

定義

ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.

酵素阻害剤

This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin

シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-] 上流と下流の製品情報

原材料

準備製品


シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-] 生産企業

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26645-35-2(シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-])キーワード:


  • 26645-35-2
  • 5-Dihydroxy-Leu-Val-erythro-3-Hydroxy-D-Asp-Cys-cis-4-Hydroxy-Pro)
  • Cyclo(Ala-2-Mercapto-Trp-4
  • PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-2-MERCAPTO-TRP-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
  • PHALLACIDIN
  • PHALLICIDIN
  • CYCLO[ALA-2-MERCAPTO-TRP-4,5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO]
  • -3-hydroxy-d-alpha-aspartyl-l-cysteinyl-cis-4-hydroxy-l-prolyl)cyclic(2-6)-s
  • cyclic(l-alanyl-2-mercapto-l-tryptophyl-4,5-dihydroxy-l-leucyl-l-valyl-erythro
  • phallacidin from amanita phalloides
  • Cyclo[L-Ala-L-Trp2(1)-4,5-dihydroxy-L-Leu-L-Val-[(3S)-3-hydroxy-D-Asp-]-L-Cys(1)-L-c4Hyp-]
  • 5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
  • CYCLO(ALA-2-MERCAPTO-TRP-4
  • PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-2-MERCAPTO-TRP-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)
  • Cyclo[L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl-L-valyl-(3S)-3-hydroxy-D-α-aspartyl-L-cysteinyl-(4S)-4-hydroxy-L-prolyl], cyclic (2→6)-thioether
  • Phallacidin DISCONTINUED
  • ファラシジン
  • シクロ[L-Ala-L-Trp2(1)-4,5-ジヒドロキシ-L-Leu-L-Val-[(3S)-3-ヒドロキシ-D-Asp-]-L-Cys(1)-L-c4Hyp-]
  • (2S)-2-[(1S,14R,18S,20S,23S,28S,31S,34R)-28-(2,3-ジヒドロキシ-2-メチルプロピル)-18-ヒドロキシ-23-メチル-15,21,24,26,29,32,35-ヘプタオキソ-31-(プロパン-2-イル)-12-チア-10,16,22,25,27,30,33,36-オクタアザペンタシクロ[12.11.11.03,11.04,9.016,20]ヘキサトリアコンタ-3(11),4,6,8-テトラエン-34-イル]-2-ヒドロキシ酢酸
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