4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸 物理性質
- 融点 :
- >257oC (dec.)
- 沸点 :
- 587.9±60.0 °C(Predicted)
- 比重(密度) :
- 1.336
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2–8 °C
- 溶解性:
- DMSO(微量)、メタノール(微量、加温)
- 酸解離定数(Pka):
- 4.35±0.10(Predicted)
- 外見 :
- 個体
- 色:
- ペールベージュ
- 安定性::
- 吸湿性
- InChI:
- InChI=1S/C17H14N4O2/c1-11-4-5-12(16(22)23)9-15(11)21-17-19-8-6-14(20-17)13-3-2-7-18-10-13/h2-10H,1H3,(H,22,23)(H,19,20,21)
- InChIKey:
- LDLZPHLSVKGFSC-UHFFFAOYSA-N
- SMILES:
- C(O)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1
- CAS データベース:
- 641569-94-0(CAS DataBase Reference)
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸 価格
もっと(17)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01APOOR16087 |
4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid |
641569-94-0 |
1g |
¥4800 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01APOOR16087 |
4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid |
641569-94-0 |
250mg |
¥4800 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCN465305 |
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid |
641569-94-0 |
250mg |
¥22200 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCN465305 |
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid |
641569-94-0 |
1g |
¥42000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCN465305 |
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid |
641569-94-0 |
2.5g |
¥60900 |
2024-03-01 |
購入 |
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸 化学特性,用途語,生産方法
使用
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.
合成
3- [(Aminoiminomethyl)amino] -4-methyl-benzoic acid methyl ester mononitrate (10 g),3-(Dimethylamino)-1-(pyridine-3-yl)prop-2-en-1-one (7.3 g), sodium hydroxide (1.7 g) was added to 1-butanol (100 mL) in a round bottom flask under nitrogen atmosphere. The reaction mass was heated to reflux temperature and stirred for 12 hours. Then the reaction mass was cooled to 25-35°C, and iN sodium hydroxide solution (1.5 g in 37 mL of DM water) was added to it throughout 20 mm. The reaction mass was heated to reflux temperature (120-125°C) and then cooled to 25-35°C. Hydrochloric acid was added to the reaction mass at 25-35°C and stirred for an hour. The material formed was filtered, washed with DM water and then dried under vacuum at 50-55°C to provide 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (8.7 g).
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸 上流と下流の製品情報
原材料
準備製品
4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸 生産企業
Global( 261)Suppliers
641569-94-0(4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸)キーワード:
- 641569-94-0
- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
- 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
- Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-
- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid
- 2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine, 3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine
- Nilotinib Intemediate 2
- 4-Methyl-3-((4-(pyridin-3-yl)
- Nilotinib EP Impurity D
- Nilotinib Carboxylic Acid Impurity
- -3-((4-(pyridin-3-yL
- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid(For export only)
- Nilotinib EP Impurity D/B
- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic aci...
- 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid
- 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci
- Nilotinib Impurity 6 (Nilotinib EP Impurity D)
- Nilotinib Hydrochloride Monohydrate EP Impurity D
- 4-Methyl-3-[[4-G-pyridinyl)-2-pyrimidinyl]amino] benzoic acid
- 4-メチル-3-[[4-(3-ピリジニル)-2-ピリミジニル]アミノ]安息香酸