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テルビナフィン

テルビナフィン 化学構造式
91161-71-6
CAS番号.
91161-71-6
化学名:
テルビナフィン
别名:
(E)-6,6,N-トリメチル-N-(1-ナフチルメチル)-2-ヘプテン-4-イン-1-アミン;(E)-N-メチル-N-(1-ナフチルメチル)-6,6-ジメチル-2-ヘプテン-4-イン-1-アミン;(E)-N-(6,6-ジメチル-2-ヘプテン-4-イニル)-N-メチル-1-ナフタレンメチルアミン;N-[(E)-6,6-ジメチル-2-ヘプテン-4-イニル]-N-メチル-1-ナフタレンメタンアミン;(E)-テルビナフィン;1-[[[(E)-6,6-ジメチル-2-ヘプテン-4-イニル](メチル)アミノ]メチル]ナフタレン;テルビナフィン
英語化学名:
Terbinafine hydrochloride
英語别名:
LAMISIL;sf-86-327;rerbinafine;TERBINAFINE;Terbinafine-d3;(E)-Terbinafine;Terbinafine Impurity 1;Terbinafine(LaMisil, Terbinex);Terbinafine cas 91161-71-6 (whatsapp:+8618830163278);(E)-6,6,N-Trimethyl-N-(1-naphtylmethyl)-2-heptene-4-yne-1-amine
CBNumber:
CB6201128
化学式:
C21H26ClN
分子量:
291.44
MOL File:
91161-71-6.mol

テルビナフィン 物理性質

CAS データベース:
91161-71-6(CAS DataBase Reference)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36

テルビナフィン 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 T3677 テルビナフィン >98.0%(HPLC)(T)
Terbinafine >98.0%(HPLC)(T)
91161-71-6 1g ¥8000 2018-12-04 購入
東京化成工業 T3677 テルビナフィン >98.0%(HPLC)(T)
Terbinafine >98.0%(HPLC)(T)
91161-71-6 5g ¥28000 2018-12-04 購入

テルビナフィン 化学特性,用途語,生産方法

効能

抗真菌薬, エルゴステロール合成阻害薬

使用

Lamisil (Novartis).

定義

ChEBI: A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the t eatment of skin and nail infections.

抗菌性

Terbinafine is active against a wide range of pathogenic fungi, including dermatophytes (Epidermophyton, Microsporum and Trichophyton spp.), various Candida spp., Aspergillus spp., some dimorphic fungi (Blastomyces dermatitidis, Histoplasma capsulatum and Sporothrix schenckii) and many dematiaceous fungi.

獲得抵抗性

Resistance has not been reported.

応用例(製薬)

A synthetic allylamine available as the hydrochloride for oral and topical administration.

薬物動態学

Oral absorption: 70–80%
Cmax 250 mg oral: c. 1 mg/L after 2 h
Plasma half-life: c. 17 h
Volume of distribution: 1000 L
Plasma protein binding: >99%
Blood concentrations increase in proportion to dosage. It is lipophilic and is rapidly and extensively distributed to body tissues. It reaches the stratum corneum by diffusion through the dermis and epidermis, and secretion in sebum. Diffusion from the nail bed is the major factor in its rapid penetration of nails. It is metabolized by the liver and the inactive metabolites are mostly excreted in the urine. The elimination half-life is prolonged in patients with hepatic or renal impairment.

臨床応用

Tinea pedis, tinea corporis, tinea cruris, tinea capitis
Onychomycosis caused by dermatophytes

副作用

These include abdominal discomfort, loss of appetite, nausea, diarrhea, headache, impairment of taste, rash and urticaria. Serious skin reactions, including Stevens– Johnson syndrome, and rare hepatotoxic reactions, including jaundice, cholestasis and hepatitis, are occasionally encountered.

テルビナフィン 上流と下流の製品情報

原材料

準備製品


テルビナフィン 生産企業

Global( 169)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32606 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 616 58
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 468 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20177 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 683 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19975 58

91161-71-6(テルビナフィン)キーワード:


  • 91161-71-6
  • Terbinafine cas 91161-71-6 (whatsapp:+8618830163278)
  • LAMISIL
  • (e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamine
  • 6-dimethyl-2-hepten-4-ynyl)-n-methyl-n-((e)-1-naphthalenemethanamin
  • sf-86-327
  • TERBINAFINE
  • trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine
  • 1-Naphthalenemethanamine, N-(2E)-6,6-dimethyl-2-hepten-4-ynyl-N-methyl-
  • N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine hydrochloride
  • (E)-N-(6,6-I)imethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine
  • rerbinafine
  • (E)-6,6,N-Trimethyl-N-(1-naphtylmethyl)-2-heptene-4-yne-1-amine
  • (E)-Terbinafine
  • 1-[[[(E)-6,6-Dimethyl-2-heptene-4-ynyl](methyl)amino]methyl]naphthalene
  • N-[(E)-6,6-Dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine
  • N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
  • 1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-
  • ( E)-N-Methyl-N-(1-naphthylMethyl)-6,6-diMethyl-hept-2-en-4-inyl-1-aMine
  • Terbinafine-d3
  • Terbinafine(LaMisil, Terbinex)
  • [(2E)-6,6-diMethylhept-2-en-4-yn-1-yl](Methyl)(naphthalen-1-ylMethyl)aMine
  • (E)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine
  • N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine
  • (6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine
  • Terbinafine Impurity 1
  • (E)-6,6,N-トリメチル-N-(1-ナフチルメチル)-2-ヘプテン-4-イン-1-アミン
  • (E)-N-メチル-N-(1-ナフチルメチル)-6,6-ジメチル-2-ヘプテン-4-イン-1-アミン
  • (E)-N-(6,6-ジメチル-2-ヘプテン-4-イニル)-N-メチル-1-ナフタレンメチルアミン
  • N-[(E)-6,6-ジメチル-2-ヘプテン-4-イニル]-N-メチル-1-ナフタレンメタンアミン
  • (E)-テルビナフィン
  • 1-[[[(E)-6,6-ジメチル-2-ヘプテン-4-イニル](メチル)アミノ]メチル]ナフタレン
  • テルビナフィン
  • 抗真菌薬
  • 農業殺菌剤
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