1-ドコサノール 化学特性,用途語,生産方法
外観
白色ペレット
定義
本品は、次の化学式で表される脂肪族アルコールである。
用途
トリートメント / コンディショナー,化粧水 / 乳液 / クリーム,ファンデーション / 下地,アウトバスヘアケア
原料由来
飽和高級アルコール（植物系のみ）
化粧品の成分用途
非水系増粘剤、結合剤、乳化安定剤
特徴
ナタネ油由来の飽和高級アルコール。乳化物の過脂肪剤で、流動性を改良。ベヘニールアルコールよりC22の含有量が若干高いタイプ。C22:約80%。
特徴
ナタネ油由来の飽和高級アルコール。乳化物の過脂肪剤で、流動性を改良。当社標準タイプ。C22:約70%。
特徴
ナタネ油由来の飽和高級アルコール。乳化物の過脂肪剤で、流動性を改良。当社汎用タイプ。C22:約65%。
特徴
高純度の飽和高級アルコール。
化学的特性
1-DOCOSANOL is white powder
使用
n-Docosanol is a binder and an emulsion stabilizer. It is also used to increase a formulation’s viscosity. This is a mixture of fatty alcohols. behenyl alcohol may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity. It may be derived either synthetically or from plants.
定義
1-DOCOSANOL is a long-chain, saturated fatty alcohol.
適応症
Docosanol (Abreva) is a long-chain saturated alcohol
that is clinically effective against HSV. It has in vitro activity
against many enveloped viruses, including CMV,
influenzavirus, and respiratory syncytial virus.
Docosanol is not directly virucidal; instead, it blocks
the entry of the virion into the host cell by inhibiting the
fusion of the viral envelope with the host plasma membrane.
Because it does not affect viral replication or protein
production, it may be less susceptible to the development
of resistance than other antiviral drugs.
一般的な説明
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells
in vitro. It has been isolated from
Clematis brevicaudata.
応用例（製薬）
1-DOCOSANOL is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis. It is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking. The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
臨床応用
Docosanol cream is approved for the over-the-counter
treatment of herpes labialis. It shortens the duration of
symptoms of cold sores and fever blisters but does not
provide symptomatic relief.
副作用
Adverse effects of docosanol are minimal. Skin irritation
occurs infrequently. Drug interactions are not anticipated.
純化方法
Crystallise docosanol from ether or chloroform/ether. [Beilstein 1 IV 1906.]
1-ドコサノール 上流と下流の製品情報
原材料
準備製品