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リオシグアット

リオシグアット 化学構造式
625115-55-1
CAS番号.
625115-55-1
化学名:
リオシグアット
别名:
リオシグアット;リオシグアト;リオシグアト (JAN)
英語化学名:
Riociguat
英語别名:
Riocguat;Riociguat;Bay 63-2521;Riociguat IMpurtiy D;Bay63-2521,Riociguat;Riociguat, BZY 632521;Riociguat (BAY 63-2521);fondaparinux sodium intermediateA-8);Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate;[4,6-DiaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]MethylcarbaMic acid Methyl ester
CBNumber:
CB62473752
化学式:
C20H19FN8O2
分子量:
422.4156632
MOL File:
625115-55-1.mol

リオシグアット 物理性質

比重(密度) :
1.51

安全性情報

リオシグアット 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-4277 リオシグアット
Riociguat
625115-55-1 1g ¥144000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-4277 リオシグアット
Riociguat
625115-55-1 250mg ¥54000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCR520000 リオシグアット
Riociguat
625115-55-1 50mg ¥106300 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01MAS122719 リオシグアット
Riociguat
625115-55-1 1g ¥472100 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-4277 リオシグアット
Riociguat
625115-55-1 5g ¥486000 2018-12-26 購入

リオシグアット 化学特性,用途語,生産方法

効能

血管拡張薬, グアニル酸シクラーゼ活性薬

商品名

アデムパス (バイエル薬品)

説明

In September 2013, Health Canada approved riociguat (also referred to as BAY 63-2521), for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) after surgical treatment or inoperable CTEPH and for the treatment of adults with pulmonary arterial hypertension (PAH). Riociguat has a dual mode of action and works by (a) sensitizing sGC to the body’s NO by stabilizing NO–sGC binding and (b) an NO-independent, direct stimulation of sGC via a different binding site. This process restores the NO–sGC–cGMP pathway and leads to increased generation of cGMP with subsequent vasodilation.
Headache, dizziness, dyspepsia/gastritis, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation were the most common adverse events ( 3%) observed during riociguat clinical trials. Riociguat comes with a black box warning for embryo-fetal toxicity.

化学的特性

Brownish Orange Solid

Originator

Bayer (Germany)

使用

Riocguat is used in the treatment for pulmonary hypertension.

定義

ChEBI: A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension an pulmonary arterial hypertension

brand name

Adempas

リオシグアット 上流と下流の製品情報

原材料

準備製品


リオシグアット 生産企業

Global( 155)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com CHINA 21676 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3195 58
Chemwill Asia Co.,Ltd.
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Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58

625115-55-1(リオシグアット)キーワード:


  • 625115-55-1
  • Riociguat IMpurtiy D
  • Riocguat
  • Riociguat
  • N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
  • Bay 63-2521
  • Carbamic acid, (4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-B)pyridin-3-yl)-5-pyrimidinyl)methyl-, methyl ester
  • Riociguat, BZY 632521
  • Riociguat (BAY 63-2521)
  • Bay63-2521,Riociguat
  • [4,6-DiaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]MethylcarbaMic acid Methyl ester
  • Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate
  • Riociguat N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
  • Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-, methyl ester
  • fondaparinux sodium intermediateA-8)
  • リオシグアット
  • リオシグアト
  • リオシグアト (JAN)
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