ベシフロキサシン塩酸塩

ベシフロキサシン塩酸塩 化学構造式
405165-61-9
CAS番号.
405165-61-9
化学名:
ベシフロキサシン塩酸塩
别名:
ベシフロキサシン塩酸塩
英語名:
Besifloxacin hydrochloride
英語别名:
CS-781;Pranoprofer;BOL-303224-A;Unii-7506A6J57t;Besifloxacin HC;Besifloxacin HCl;Besivance hydrochloride;Hydrochloric Besifloxacin;7-[(3R)-3-AMinohexahydro-;Becifloxacin Hydrochloride
CBNumber:
CB62492988
化学式:
C19H22Cl2FN3O3
分子量:
430.3
MOL File:
405165-61-9.mol
MSDS File:
SDS

ベシフロキサシン塩酸塩 物理性質

融点 :
>210°C (dec.)
貯蔵温度 :
Inert atmosphere,2-8°C
溶解性:
メタノール(わずかに、加熱、超音波処理)、水(わずかに、加熱、超音波処理)
外見 :
個体
色:
オフホワイトからライトベージュ
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
絵表示(GHS) GHS hazard pictograms
注意喚起語 警告
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告 GHS hazard pictograms
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ベシフロキサシン塩酸塩 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCB319000 ベシフロキサシン塩酸塩
Besifloxacin Hydrochloride
405165-61-9 10mg ¥26400 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCB319000 ベシフロキサシン塩酸塩
Besifloxacin Hydrochloride
405165-61-9 25mg ¥50400 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCB319000 ベシフロキサシン塩酸塩
Besifloxacin Hydrochloride
405165-61-9 50mg ¥95100 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCB319000 ベシフロキサシン塩酸塩
Besifloxacin Hydrochloride
405165-61-9 100mg ¥161200 2023-06-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCB319000 ベシフロキサシン塩酸塩
Besifloxacin Hydrochloride
405165-61-9 200mg ¥322600 2023-06-01 購入

ベシフロキサシン塩酸塩 化学特性,用途語,生産方法

効能

抗菌薬, 核酸合成阻害薬

説明

Besifloxacin is a new fluoroquinolone antibacterial for ophthalmic use. It is indicated for the treatment of bacterial conjunctivitis, one of the most common ocular infections encountered in the primary care setting. Although the previously marketed fluoroquinolones ciprofloxacin, levofloxacin, ofloxacin, gatifloxacin, and moxifloxacin have been widely used to treat bacterial conjunctivitis, their continued utility is hampered by the emergence of resistance among key ocular isolates such as Staphylococcus aureus. Besifloxacin is the first fluoroquinolone developed exclusively for topical ophthalmic use. Unlike the previously marketed fluoroquinolones, besifloxacin has not been used systemically and is not in development as a systemic agent. Its exclusive indication as a topical agent is expected to reduce the overall environmental exposure of bacteria to besifloxacin, which may contribute to a lower risk for the emergence of bacterial resistance. Fluoroquinolones derive their antibacterial activity via inhibition of two essential bacterial enzymes, DNA gyrase and topoisomerase IV, which regulate processes of DNA replication. Besifloxacin inhibits DNA gyrase and topoisomerase IV from Streptococcus pneumoniae (IC50 = 1 and 0.4 mg/ L, respectively) and Escherichia coli (IC50 = 1 and 10 mg/L, respectively).

化学的特性

Pale Yellow Solid

使用

Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic

副作用

The most common adverse event reported in patients treated with besifloxacin ophthalmic suspension was conjunctival redness. Other less common adverse events were blurred vision, eye pain, eye irritation, eye pruritus, and headache.

ベシフロキサシン塩酸塩 上流と下流の製品情報

原材料

準備製品


ベシフロキサシン塩酸塩 生産企業

Global( 223)Suppliers
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ベシフロキサシン塩酸塩  スペクトルデータ(1HNMR)


405165-61-9(ベシフロキサシン塩酸塩)キーワード:


  • 405165-61-9
  • (R)-7-(3-AMinohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinolin-3-carboxylic acid HCl
  • 3-Quinolinecarboxylic acid, 7-[(3R)-3-aMinohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI)
  • (R)-7-(3-aMinoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
  • Besifloxacin HCl
  • Unii-7506A6J57t
  • (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride
  • Besifloxacin hydrochloride
  • Becifloxacin Hydrochloride
  • BESIFLOXACIN HCL INTERMEDIATES
  • Hydrochloric Besifloxacin
  • 3-Quinolinecarboxylic acid, 7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1)
  • Besifloxacin HCl (Besivance)
  • Besifloxacin hydrochloride, >=98%
  • 7-[(3R)-3-AMinohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrochloride
  • 7-[(3R)-3-AMinohexahydro-
  • Besifloxacin HC
  • CS-781
  • Besifloxacin hydrochloride (405165-61-9)
  • Besivance hydrochloride
  • BOL-303224-A
  • Besifloxacin hydrochloride USP/EP/BP
  • Besifloxacin Hydrochloride (Contains ~15% Inorganics)
  • Besifloxacin Hcl Intermediate
  • 7-(3-aminoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
  • Pranoprofer
  • ベシフロキサシン塩酸塩
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