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アレクチニブ

アレクチニブ 化学構造式
1256580-46-7
CAS番号.
1256580-46-7
化学名:
アレクチニブ
别名:
アレクチニブ
英語化学名:
Alectinib
英語别名:
AF-802;CS-217;RG-7853;alectinb;Alectinib;CH5424802;RO5424802;Alecitinib;RO 5424802;AF-802,RG-7853
CBNumber:
CB62534680
化学式:
C30H34N4O2
分子量:
483
MOL File:
1256580-46-7.mol

アレクチニブ 物理性質

沸点 :
722.5±60.0 °C(Predicted)
比重(密度) :
1.28
酸解離定数(Pka):
13.70±0.40(Predicted)

安全性情報

アレクチニブ 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

アレクチニブ 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, 未分化リンパ腫キナーゼ(ALK)阻害薬

化学的特性

White to Off-White Solid

使用

CH5424802 is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. CH5424802 have been cl inically evaluated for the treatment of patients with ALK-driven tumors.

定義

ChEBI: An organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydr chloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer.

適応症

Alectinib (Alecensa(R), Roche) was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.

アレクチニブ 上流と下流の製品情報

原材料

準備製品


アレクチニブ 生産企業

Global( 200)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
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1256580-46-7(アレクチニブ)キーワード:


  • 1256580-46-7
  • RG-7853
  • Alectinib
  • 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CH5424802
  • CH5424802, Alectinib, AF802
  • 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6
  • Alecitinib
  • 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
  • 9-ETHYL-6,6-DIMETHYL-8-(4-MORPHOLINOPIPERIDIN-1-YL)-11-OXO-6,11-DIHYDRO-5H-BENZO[B]CARBAZOLE-3-CARBONITRILE
  • CH5424802
  • Alectinib free base
  • 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
  • Alectinib free base
  • AF-802,RG-7853
  • 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802)
  • CH5424802-alectinib
  • alectinb
  • AF-802
  • CH-5424802/RG-7853
  • Alectinib (CH5424802)
  • AF-802; CH 5424802; CH-5424802; AF802; AF 802
  • CS-217
  • AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, ALECTINIB; BRAND NAME: ALECENSA
  • brand name: Alecensa
  • RO 5424802
  • RO5424802
  • RO5424802, Alectinib
  • アレクチニブ
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