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2-(ジメチルアミノ)エタノール

2-(ジメチルアミノ)エタノール 化学構造式
108-01-0
CAS番号.
108-01-0
化学名:
2-(ジメチルアミノ)エタノール
别名:
2-(ジメチルアミノ)エタノール;N,N-ジメチルアミノエタノール;2-ジメチルアミノエタノール;ジメチル(2-ヒドロキシエチル)アミン;デアノール;2-(N,N-ジメチルアミノ)エタノール;N,N-ジメチルエタノールアミン;N,N-ジメチル-2-ヒドロキシエタンアミン;2-ジ(メチルアミノ)エタノール;2ジメチルアミノエタノル;2-ヒドロキシエチルジメチルアミン;ジメチルMEA;ジメチルアミノエタノール;2‐ジメチルアミノエタノール;2-(ジメチルアミノ)エタノール N,N-ジメチルエタノールアミン;2-(ジメチルアミノ)エタノール(DMAE);2-(ジメチルアミノ)エタノール, 99+%;2 - ジメチルアミノエタノール
英語化学名:
2-Dimethylaminoethanol
英語别名:
DMAE;DEANOL;FC DMEA;Varesal;Panclar;Bimanol;kalpurp;Liparon;Kalpur p;propaminea
CBNumber:
CB6256870
化学式:
C4H11NO
分子量:
89.14
MOL File:
108-01-0.mol

2-(ジメチルアミノ)エタノール 物理性質

融点 :
−70 °C(lit.)
沸点 :
134-136 °C(lit.)
比重(密度) :
0.886 g/mL at 20 °C(lit.)
蒸気圧:
100 mm Hg ( 55 °C)
屈折率 :
n20/D 1.4294(lit.)
闪点 :
105 °F
貯蔵温度 :
Flammables area
溶解性:
alcohol: miscible(lit.)
外見 :
Liquid
酸解離定数(Pka):
pK1:9.26(+1) (25°C)
色:
Clear colorless to pale yellow
PH:
10.5-11 (100g/l, H2O, 20℃)
爆発限界(explosive limit):
1.4-12.2%(V)
水溶解度 :
miscible
凝固点 :
-59.0℃
Sensitive :
Hygroscopic
Merck :
14,2843
BRN :
1209235
安定性::
Stable. Flammable. Incompatible with oxidizing agents, copper, copper alloys, zinc, acids, galvanised iron. Hygroscopic.
InChIKey:
UEEJHVSXFDXPFK-UHFFFAOYSA-N
CAS データベース:
108-01-0(CAS DataBase Reference)
NISTの化学物質情報:
Ethanol, 2-(dimethylamino)-(108-01-0)
EPAの化学物質情報:
Ethanol, 2-(dimethylamino)-(108-01-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  C
Rフレーズ  10-20/21/22-34
Sフレーズ  25-26-36/37/39-45
RIDADR  UN 2051 8/PG 2
WGK Germany  1
RTECS 番号 KK6125000
自然発火温度 245 °C
TSCA  Yes
国連危険物分類  8
容器等級  II
HSコード  29221980
有毒物質データの 108-01-0(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 2130 mg/kg LD50 dermal Rabbit 1220 mg/kg
消防法 危険物第4類第二石油類(水溶性)
化審法 (2)-297, (2)-353
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H226 引火性の液体および蒸気 引火性液体 3 警告
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P310 ただちに医師に連絡すること。
P370+P378 火災の場合:消火に...を使用すること。
P405 施錠して保管すること。

2-(ジメチルアミノ)エタノール 価格 もっと(28)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAB23616 2-(ジメチルアミノ)エタノール, 99+%
2-(Dimethylamino)ethanol, 99+%
108-01-0 250mL ¥4250 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01AFAB23616 2-(ジメチルアミノ)エタノール, 99+%
2-(Dimethylamino)ethanol, 99+%
108-01-0 1000mL ¥12480 2018-12-26 購入
東京化成工業 D0649 2-(ジメチルアミノ)エタノール >99.0%(GC)(T)
2-(Dimethylamino)ethanol >99.0%(GC)(T)
108-01-0 25mL ¥1600 2018-12-04 購入
東京化成工業 D0649 2-(ジメチルアミノ)エタノール >99.0%(GC)(T)
2-(Dimethylamino)ethanol >99.0%(GC)(T)
108-01-0 500mL ¥3000 2018-12-04 購入
関東化学株式会社(KANTO) 10343-00 2‐ジメチルアミノエタノール >98.0%(GC)
2‐Dimethylaminoethanol >98.0%(GC)
108-01-0 500mL ¥2800 2018-12-13 購入

2-(ジメチルアミノ)エタノール MSDS


2-Dimethylaminoethanol

2-(ジメチルアミノ)エタノール 化学特性,用途語,生産方法

外観

無色~わずかにうすい黄色, 澄明の液体

定義

本品は、次の化学式で表されるアミノアルコールである。

溶解性

水に混和。エタノール, エーテルに易溶。水、エタノール及びアセトンに極めて溶けやすい。

用途

塗料用溶剤、合成樹脂、乳化剤、医薬原料

用途

染料、せんい、腐食防止剤、医薬品、化学合成の中間体、局所麻酔薬プロカイン等の前駆体、アミノ樹脂安定剤、防さび剤

化粧品の成分用途

pH調整剤

効能

向知性薬

化学的特性

Colourless liquid

使用

dimethyl MEA (DMAE) is also known as dimethylaminoethanol. Studies indicate skin-firming properties, and an ability to reduce the appearance of fine lines and wrinkles as well as dark circles under the eyes. It is considered anti-aging, and antiinflammatory, and has exhibited free-radical scavenging activity.

調製方法

Synthesis of dimethylaminoethanol can be accomplished from equimolar amounts of ethylene oxide and dimethylamine (HSDB 1988).

定義

ChEBI: A tertiary amine that is ethanolamine having two N-methyl substituents.

一般的な説明

A clear colorless liquid with a fishlike odor. Flash point 105°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals.

空気と水の反応

Flammable. Partially soluble in water and less dense than water.

反応プロフィール

DIMETHYLAMINOETHANOL is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. N,N-Dimethylethanolamine may react vigorously with oxidizing materials.

健康ハザード

Inhalation of the vapor or mist can cause irritation to the upper respiratory tract. Asthmatic symptoms have been reported. Extremely irritating; may cause permanent eye injury. Corrosive; will cause severe skin damage with burns and blistering. Ingestion may cause damage to the mucous membranes and gastrointestinal tract.

健康ハザード

Dimethylaminoethanol is classified as a mild skin irritant and a severe eye irritant (HSDB 1988). Doses as high as 1200 mg daily produce no serious side effects and a single dose of 2500 mg taken in a suicide attempt had no adverse effects (Gosselin et al 1976). Reported side effects for the acetamidobenzoate salt of dimethylaminoethanol include occipital headache, constipation, muscle tenseness, restlessness, increased irritability, insomnia, pruritus, skin rash, postural hypotension, and weight loss (HSDB 1988). Under laboratory conditions, asthmatic responses resulted after exposure to a 2% dimethylaminoethanol solution to a spray painter who earlier was exposed to a similar concentration of dimethylaminoethanol via a particular paint (Vallieres et al 1977). Serious cholinergic side effects were reported in a 37 yr-old woman with tardive dyskinesia who had been taking dimethylaminoethanol (Nesse and Carroll 1976). After chronic treatment (5 months) with dimethylaminoethanol, marked sialism, bronchospasm, and parkinson rigidity was observed in an 89 yr-old male with a 50 yr history of chronic paranoid schizophrenia and symptoms of tardive dyskinesia (Mathew et al 1976). Dimethylaminoethanol appears to have a relatively low order of toxicity (HSDB 1988). Upon chronic administration in humans, plasma choline concentrations were found to be increased (Ceder et al 1978). No reports were found in the literature regarding carcinogenic or mutagenic potential.

工業用途

Dimethylaminoethanol is used as a chemical intermediate for antihistamines and local anesthetics; as a catalyst for curing epoxy resins and polyurethanes; and as a pH control agent for boiler water treatment. However, dimethylaminoethanol in the salt form, (i.e. dimethylaminoethanol acetamidobenzoate) is primarily utilized therapeutically as an antidepressant (HSDB 1988).

安全性プロファイル

Moderately toxic by ingestion, inhalation, skin contact, intraperitoneal, and subcutaneous routes. A skin and severe eye irritant. Used medically as a central nervous system stimulant. Flammable liquid when exposed to heat or flame; can react vigorously with oxidzing materials. Ignites spontaneously in contact with cellulose nitrate of high surface area. To fight fire, use alcohol foam, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx

代謝

When administered orally, dimethylaminoethanol acetamidobenzoate (the therapeutic salt formulation) has been shown to cross the blood-brain barrier (HSDB 1988). Two other studies have examined the pharmacokinetics of dimethylaminoethanol in rats (Dormand et al 1975) and healthy adults (Bismut et al 1986).
It has been postulated that dimethylaminoethanol undergoes endogenous methylation (LaDu et al 1971). After intravenous treatment of mice with [14C]-labeled dimethylaminoethanol in the brain, dimethylaminoethanol yielded phosphoryldimethylaminoethanol and phosphatidyldimethylaminoethanol. Acid-soluble and lipid cholines derived from dimethylaminoethanol also were found in brain (Miyazaki et al 1976). While examining the pharmacokinetics of the maleate acid of [14C]-dimethylaminoethanol in rats, Dormand et al (1975) observed that dimethylaminoethanol was metabolized in the phospholipid cycle and produced metabolites such as phosphoryldimethylaminoethanolamine, and glycerophosphatidylcholine. In kainic-acid lesioned rats, dimethylaminoethanol was converted to a substance which cross-reacted in the radioenzymatic assay for acetylcholine (London et al 1978). Ansell and Spanner (1979) demonstrated that [14C]-dimethylaminoethanol rapidly disappeared from brain; after 0.5, 1, and 7 h, only 30, 27, and 16% of the administered radioactivity, respectively, remained in the brain after intracerebral injection. They also showed that brain levels of phosphodimethylaminoethanol increased to a maximum at 1-2 h and decreased afterwards, whereas concentrations of phosphatidylethanolamine increased continuously throughout the 7 h observation period. This study further found that after i.p. injections of labeled dimethylaminoethanol, the brain content of phosphatidylethanolamine increased through the 7 h period and the levels were 10-40 fold higher than those of phosphodimethylaminoethanol.

純化方法

Dry the amine with anhydrous K2CO3 or KOH, and fractionally distil it. [Beilstein 4 IV 1424.]

2-(ジメチルアミノ)エタノール 上流と下流の製品情報

原材料

準備製品


2-(ジメチルアミノ)エタノール 生産企業

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108-01-0(2-(ジメチルアミノ)エタノール)キーワード:


  • 108-01-0
  • LUPRAGEN(R) N 101
  • BETA-(DIMETHYLAMINO)ETHANOL
  • BETA-DIMETHYLAMINOETHYL ALCOHOL
  • DMAE
  • DIMETHYLETHANOLAMINE
  • DIMETHYL(HYDROXYETHYL)AMINE
  • DIMETHYLAMINOETHANOL
  • DIMETHYL(2-HYDROXYETHYL)AMINE
  • DEANOL
  • ETHANOL, 2-(DIMETHYLAMINO)-
  • AKOS BBS-00004310
  • 2-HYDROXYETHYLDIMETHYLAMINE
  • 2-DIMETHYLAMINOETHANOL
  • 2-(DIMETHYLAMINO)ETHYL ALCOHOL
  • 2-DIMETHYLAMINOETHANOL, 98%2-DIMETHYLAMINOETHANOL, 98%2-DIMETHYLAMINOETHANOL, 98%
  • DIMETHYLAMINOETHANOLRESEARCH GRADE
  • 2-Dimethylaminoethanol,N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethylethanolamine
  • 2-(Dimethylamino)-ethanol, synthesis grade
  • N,N-Dimethylethanola
  • LupragenN101(N-Dimethylethanolamine)
  • FC DMEA
  • N,N-DiMethylethanolaMine, 99% 250ML
  • Jeffcat DMEA
  • N,N-Dimethylethanolamine 2-Hydroxyethyldimethylamine
  • |N|,|N|-diMethylethanolaMine (DMEA)
  • 2-DiMethylaMinoethanol >=99.5%
  • 2-DiMethylaMinoethanol purified by redistillation, >=99.5%
  • 2-Dimethylaminoethanol purum, >=98.0% (GC)
  • 2-(Dimethylamine)ethanol
  • 2-(Dimethylamino)-1-ethanol
  • 2-(ジメチルアミノ)エタノール
  • N,N-ジメチルアミノエタノール
  • 2-ジメチルアミノエタノール
  • ジメチル(2-ヒドロキシエチル)アミン
  • デアノール
  • 2-(N,N-ジメチルアミノ)エタノール
  • N,N-ジメチルエタノールアミン
  • N,N-ジメチル-2-ヒドロキシエタンアミン
  • 2-ジ(メチルアミノ)エタノール
  • 2ジメチルアミノエタノル
  • 2-ヒドロキシエチルジメチルアミン
  • ジメチルMEA
  • ジメチルアミノエタノール
  • 2‐ジメチルアミノエタノール
  • 2-(ジメチルアミノ)エタノール N,N-ジメチルエタノールアミン
  • 2-(ジメチルアミノ)エタノール(DMAE)
  • 2-(ジメチルアミノ)エタノール, 99+%
  • 2 - ジメチルアミノエタノール
  • 抗欝薬
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