(S)-プラミペクソール二塩酸塩
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H336 |
眠気やめまいのおそれ |
特定標的臓器毒性、単回暴露； 麻酔作用 |
3 |
警告 |
|
P261, P271, P304+P340, P312,P403+P233, P405, P501 |
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P271 |
屋外または換気の良い場所でのみ使用すること。 |
| P301+P312 |
飲み込んだ場合：気分が悪い時は医師に連絡する こと。 |
|
(S)-プラミペクソール二塩酸塩 価格
もっと(11)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCP700755 |
(S)-プラミペクソール二塩酸塩
(S)-Pramipexole Dihydrochloride |
104632-25-9 |
100mg |
￥39300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS093186 |
(S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine dihydrochloride |
104632-25-9 |
250mg |
￥121900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A1237 |
プラミペキソール 二塩酸塩 >98% (HPLC), powder
Pramipexole dihydrochloride >98% (HPLC), powder |
104632-25-9 |
10mg |
￥16200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A1237 |
プラミペキソール 二塩酸塩 >98% (HPLC), powder
Pramipexole dihydrochloride >98% (HPLC), powder |
104632-25-9 |
50mg |
￥74700 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCP700755 |
(S)-プラミペクソール二塩酸塩
(S)-Pramipexole Dihydrochloride |
104632-25-9 |
5mg |
￥17400 |
2024-03-01 |
購入 |
(S)-プラミペクソール二塩酸塩 化学特性,用途語,生産方法
説明
Mirapex, an non ergot derivative, was launched in the US for treatment of
Parkinson's disease. It can be prepared by two related routes, 5 steps and 3 steps,
both involving an optical resolution with L-(+)-tartaric acid to afford the (S)-isomer.
Mechanistically, it is a presynaptic dopamine D
2 autoreceptor agonist which also
activates D
3-receptors. It is well absorbed from the GI and excreted in the urine
essentially unchanged with a half-life of 8-12 hr. Mirapex had favorable effects on the
symptoms without levodopa for patients with advanced PD and allowed a 27%
reduction in use of levodopa in combination therapy. It had an adverse events profile
similar to other dopamine agonists and in advanced patients reduced the mean "on-off"
hr/day from 6 to 4. It was safe but not efficacious in all patients.
化学的特性
White Crystalline Powder
定義
ChEBI: A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole.
一般的な説明
Pramipexole dihydrochloride,(S)-2-amino-6-propylamino-dihydrochloride(Mirapex), is a white to off-white powder soluble in water,slightly soluble in methanol and ethanol, and practically insolublein dichloromethane. Following oral administration,pramipexole is readily absorbed. Pharmacokinetic propertiesdiffer between men and women, with area under the curve(AUC) for each dose level being 35% to 43% greater inwomen, mainly because of a 24% to 27% lower oral clearance.The drug undergoes minimal hepatic biotransformationand is excreted virtually unchanged in the urine by the renaltubular secretion. Pramipexole interacts with drugs excretedby renal tubular secretion (H2-antagonists, diuretics, verapamil,quinidine, quinine), which leads to a decreased clearanceof pramipexole.44,45 Pramipexole is indicated fortreatment of the signs and symptoms of idiopathic PD, aloneor in combination with levodopa. It is also indicated for symptomatictreatment of moderate to severe idiopathic restlesslegs syndrome (RLS).
(S)-プラミペクソール二塩酸塩 上流と下流の製品情報
原材料
準備製品
(S)-プラミペクソール二塩酸塩 生産企業
Global( 309)Suppliers
(S)-プラミペクソール二塩酸塩 スペクトルデータ(1HNMR)
104632-25-9((S)-プラミペクソール二塩酸塩)キーワード:
- 104632-25-9
- PRAMIPEXOLE HCL
- PRAMIPEXOL HCL
- (s)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
- PramipexoleDihcl
- (S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HCltetrahydrobenzothiazol
- (s)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine, Dihydrochloride
- Pramipexole dihydrochloride
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
- PraMipexole dihydrochlor
- 2,6-BenzothiazolediaMine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6S)-
- (S)-Pramipexole Dihydrochloride
- (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine dihydrochloride
- 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (6S)-
- 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (S)-
- Pramipexole dihydrochloride [usan]
- 2,6-BenzothiazolediaMine,4,5,6,7-tetrahydro-N6-propyl-, hydrochl
- pramipexole hydrochloride anhydrous
- CS-296
- Pramipexole dihydrochloride(USP)
- Pramipexole Impurity 4 USP/EP/BP
- Pramipexole dihydrochloride salt
- Pramepexole 2HCl
- Pramipexole dihydrochlorideQ: What is
Pramipexole dihydrochloride Q: What is the CAS Number of
Pramipexole dihydrochloride Q: What is the storage condition of
Pramipexole dihydrochloride
- (S)-Pramipexole-d7 Dihydrochoride
- PRAMIPEXOLE DIHYDROCHLORIDE
- PRAMIPEXOLE HYDROCHLORIDE
- Praxole
- Benzoicacid,3-bromo-6-ethyl-
- (S)-Pramipexole (hydrochloride)
- Crufomate Impurity 4
- (S)-プラミペクソール二塩酸塩
- プラミペキソール 二塩酸塩