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VH 032, アミン塩酸塩

VH 032, アミン塩酸塩 化学構造式
1448189-80-7
CAS番号.
1448189-80-7
化学名:
VH 032, アミン塩酸塩
别名:
VH 032, アミン塩酸塩
英語名:
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
英語别名:
VHL Ligand 1;ULM-1;ULM-1(MDK7526HCL);VHL Ligand 1 HCl salt;141003;CS-2718;ULM-1 HCl;UBI-10003;MDK7526 HCl;MDK-7526;ULM-1
CBNumber:
CB63156669
化学式:
C22H31ClN4O3S
分子量:
467.03
MOL File:
1448189-80-7.mol

VH 032, アミン塩酸塩 物理性質

貯蔵温度 :
2-8°C
溶解性:
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
外見 :
A crystalline solid
InChIKey:
JYRTWGCWUBURGU-XIMRXPCLNA-N
SMILES:
C([C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1.Cl |&1:1,3,9,r|

安全性情報

HSコード  2934100090

VH 032, アミン塩酸塩 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC6462 VH 032, アミン塩酸塩
VH 032, amine hydrochloride 		1448189-80-7 100mg ￥176000 2024-03-01 購入
Sigma-Aldrich Japan 901490 ≥97%
(S,R,S)-AHPC hydrochloride ≥97%		 1448189-80-7 100MG ￥139000 2024-03-01 購入

VH 032, アミン塩酸塩 化学特性,用途語,生産方法

説明

VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Item No. 21622).

使用

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.

VH 032, アミン塩酸塩 上流と下流の製品情報

原材料

準備製品

VH 032, アミン塩酸塩 生産企業

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VH 032, アミン塩酸塩  スペクトルデータ(1HNMR)

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride(1448189-80-7)1HNMR
  • 1448189-80-7
  • (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
  • Protein degrader 1 (hydrochloride)
  • (S,R,S)-AHPC hydrochloride
  • MDK-7526;ULM-1
  • (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide hydrochloride
  • Protein degrader 1
  • 141003
  • (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride
  • CS-2718
  • Degradation Inducing Moiety A
  • PROTEIN DEGRADER 1 HYDROCHLORIDE; MDK7526 HCL; MDK7526; MDK-7526; MDK 7526; VHL LIGAND 1; ULM-1; VH032 DESACETYL HYDROCHLORIDE; VH032 AMINE HCL; DEGRADATION INDUCING MOIETY A;
  • VH032 amine HCl
  • VH032 desacetyl Hydrochloride
  • MDK7526 HCl
  • (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine
  • VHL Ligand 1 (hydrochloride)
  • PROTAC-VHL-Ligand 1
  • ULM-1 HCl
  • PROTAC-VHL-ligand hydrochloride
  • (S,R,S)-AHPC hydrochloride >=97%
  • MDK7526(Protein degrader 1)
  • (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride ISO 9001：2015 REACH
  • VH032-NH2 hydrochloride
  • VHL ligand 1 hydrochlorid
  • Protein degrader 1 HCl)
  • ULM-1HCl (MDK7526 HCl
  • ULM-1
  • VHL Ligand 1
  • ULM-1(MDK7526HCL)
  • VHL Ligand 1 HCl salt
  • VH 032, アミン塩酸塩
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