クロルプロチキセン
クロルプロチキセン 物理性質
- 融点 :
- 97-98°
- 沸点 :
- 160 °C(Press: 0.04 Torr)
- 比重(密度) :
- 1.1048 (rough estimate)
- 屈折率 :
- 1.6000 (estimate)
- 貯蔵温度 :
- Inert atmosphere,2-8°C
- 溶解性:
- DMSO : 33.33 mg/mL (105.52 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- 外見 :
- powder to crystal
- 酸解離定数(Pka):
- pKa 8.4(H2O) (Uncertain)
- 色:
- White to Orange to Green
- 水溶解度 :
- 385.8ug/L(22.5℃)
- 安定性：:
- Hygroscopic
- NISTの化学物質情報:
- Chlorprothixene(113-59-7)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
| H336 |
眠気やめまいのおそれ |
特定標的臓器毒性、単回暴露； 麻酔作用 |
3 |
警告 |
|
P261, P271, P304+P340, P312,P403+P233, P405, P501 |
|
| 注意書き |
|
クロルプロチキセン 価格
もっと(9)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-3023 |
クロルプロチキセン
Chlorprothixene |
113-59-7 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-3023 |
クロルプロチキセン
Chlorprothixene |
113-59-7 |
5g |
￥25000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-3023 |
Chlorprothixene |
113-59-7 |
25g |
￥60000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-3023 |
Chlorprothixene |
113-59-7 |
100g |
￥125000 |
2024-03-01 |
購入 |
|
東京化成工業
|
C3505 |
クロルプロチキセン >98.0%(T)
Chlorprothixene
>98.0%(T) |
113-59-7 |
250mg |
￥4900 |
2024-03-01 |
購入 |
クロルプロチキセン 化学特性,用途語,生産方法
外観
白色～黄赤色～緑色粉末～結晶
効能
統合失調症治療薬, ドパミン受容体拮抗薬
説明
In 2002, the American Association of Poison Control Centers’
Toxic Exposure Surveillance System reported 5224 human
exposures to phenothiazines, thioxanthenes, and other neuroleptic
medications; 3691 were in adults and 808 in children.
Unintentional and intentional exposures accounted for 43.7
and 47.8%, respectively. There were 417 (8.0%) adverse drug
reactions reported. Thioxanthenes are chemical compounds in
which the oxygen atom in xanthene is replaced with a sulfur
atom. They are also related to phenothiazines. Several derivatives
are used as typical antipsychotics in the treatment of
schizophrenia and other psychoses. The thioxanthenes, as
a class, are closely related chemically to the phenothiazines. The
major structural difference is that the nitrogen at position 10 in
the phenothiazines is replaced by a carbon atom with a double
bond to the side chain, as shown in the chemical structure of
flupenthixol, which has a double-bonded carbon in the number
10 position. Clopenthixol is a typical antipsychotic drug of the
thioxanthenes class and a racemic mixture of cis and trans
isomers. Zuclopenthixol, the pure cis isomer, has been much
more widely used. Both drugs are equally effective as antipsychotics
and have similar adverse effect profiles, but clopenthixol
is half as active on a milligram-to-milligram basis and appears
to produce more sedation in comparison.
使用
Chlorprothixene has an antipsychotic and sedative action. It has expressed antiemetic
activity. It is used in various psychoses, schizophrenia, reactive and neurotic depression
with prevalent anxious symptomatology, and in conditions of excitement associated with
fear and stress. It may be used in small doses as a sedative agent in neurosis.
環境運命予測
Long-range transport: handling of thioxanthenes should
only be performed by personnel trained and familiar
with handling potent active pharmaceutical ingredients.
In case of handling, avoid inhalation and contact with
skin, eyes, and clothing, as these materials may be an
irritant. These substances are considered nonhazardous
for transport.
クロルプロチキセン 上流と下流の製品情報
原材料
準備製品
クロルプロチキセン 生産企業
Global( 185)Suppliers
クロルプロチキセン スペクトルデータ(1HNMR)
113-59-7(クロルプロチキセン)キーワード:
- 113-59-7
- (3E)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
- (alpha-2-chloro-9-omega-dimethylamino-propylamine)thioxanthene
- 2-chloro-n,n-dimethylthioxanthene-delta(sup9),gamma-propylamine
- 2-Chloro-N,N-dimethylthioxanthene-delta9, gamma-propylamine
- 3-(2-chloro-9H-thioxanthen-9-ylidene)-N-,N-dimethyl-1-propanamine
- 3-(2-chloro-9h-thioxanthen-9-ylidene)-n,n-dimethyl-1-propanamine
- 9H-Thioxanthene, 1-propanamine deriv.
- 9H-thioxanthene,1-propanaminederiv.
- alpha-2-chloro-10-(3-dimethylaminopropylidene)-thiaxanthene
- alpha-Chlorprothixene
- Chloroprothixene
- Chlorprothixen
- Chlorprothixine
- Chlorprotixen
- Chlorprotixene
- Chlorprotixine
- Chlothixen
- cis-2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene
- cis-Chlorprothixene
- CPX
- gamma-propylamine,2-chloro-n,n-dimethyl-thioxanthene-delta(sup9
- Iaractan
- MK 184
- mk184
- N 714
- N 714C
- n#714trans
- n714
- n714c
- n-dimethyl-3-(2-chloro-9h-thioxanthen-9-ylidene)-(z)-1-propanamin
- α-クロルプロチキセン
- クロチキセン
- イアラクタン
- α-クロロチキセン
- クロロチキセン
- トリクタール
- パキシル
- タクタラン
- ベタカルム
- cis-クロルプロチキセン
- 3-[(Z)-2-クロロ-9H-チオキサンテン-9-イリデン]-N,N-ジメチル-1-プロパンアミン
- クロルプロチキセン
- (Z)-N,N-ジメチル-3-(2-クロロ-9H-チオキサンテン-9-イリデン)-1-プロパンアミン
- トラキラン
- (Z)-3-(2-クロロ-9H-チオキサンテン-9-イリデン)-N,N-ジメチル-1-プロパンアミン
- レントベット
- タラサン
- トルキシル
- トルキサール
- タラクタン
- クロルプロチキセン (JAN)
- {3-[(9Z)-2-クロロ-9H-チオキサンテン-9-イリデン]プロピル}ジメチルアミン
- 抗精神病薬