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コルヒチン

コルヒチン  化学構造式
64-86-8
CAS番号.
64-86-8
化学名:
コルヒチン
别名:
コルヒチン (≦5%酢酸エチル含む);(7S)-1,2,3,10-テトラメトキシ-7α-(アセチルアミノ)-5,6,7,9-テトラヒドロベンゾ[a]ヘプタレン-9-オン;コルチシン;(7S)-(-)-コルヒチン;N-[[(7S)-1,2,3,10-テトラメトキシ-9-オキソ-5,6,7,9-テトラヒドロベンゾ[a]ヘプタレン]-7α-イル]アセトアミド;コルヒネオス;コルキシン;(7S)-コルキシン;コルヒチン;(S)-7α-アセチルアミノ-6,7-ジヒドロ-1,2,3,10-テトラメトキシベンゾ[a]ヘプタレン-9(5H)-オン;(7S)-5,6,7,9-テトラヒドロ-1,2,3,10-テトラメトキシ-9-オキソ-N-アセチルベンゾ[a]ヘプタレン-7α-アミン;(S)-7-アセチルアミノ-6,7-ジヒドロ-1,2,3,10-テトラメトキシベンゾ[a]ヘプタレン-9(5H)-オン;(-)-コルヒチン;コンディロン;コルチセインメチルエーテル;コルチネオス;N-[[(S)-1,2,3-トリメトキシ-9-オキソ-10-メトキシ-5,6,7,9-テトラヒドロベンゾ[a]ヘプタレン]-7α-イル]アセトアミド;コルヒソール;(-)-コルキシン;コルサロイド
英語化学名:
Colchicine
英語别名:
nsc757;COLCIN;NSC 757;Condylon;Colchicin;Colsaloid;COLCHISOL;len-7-yl)-;Colchlcine;Colchicina
CBNumber:
CB6391144
化学式:
C22H25NO6
分子量:
399.44
MOL File:
64-86-8.mol

コルヒチン 物理性質

融点 :
150-160 °C (dec.)(lit.)
沸点 :
522.37°C (rough estimate)
比旋光度 :
-250 º (c=1, alcohol)
比重(密度) :
1.2770 (rough estimate)
屈折率 :
1.5614 (estimate)
貯蔵温度 :
2-8°C
溶解性:
H2O: 10 mg/mL
外見 :
powder
酸解離定数(Pka):
12.36(at 20℃)
色:
white to yellow with a green cast
水溶解度 :
45 g/L (20 ºC)
Sensitive :
Light Sensitive
Merck :
14,2471
BRN :
2228813
安定性::
Stable. Light sensitive. Incompatible with strong oxidizing agents.
InChIKey:
IAKHMKGGTNLKSZ-INIZCTEOSA-N
CAS データベース:
64-86-8(CAS DataBase Reference)
NISTの化学物質情報:
Colchicine(64-86-8)
EPAの化学物質情報:
Colchicine (64-86-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T+,T,Xi
Rフレーズ  26/28-41-46
Sフレーズ  13-45-36/37/39-28-26-53
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS 番号 GH0700000
TSCA  Yes
国連危険物分類  6.1
容器等級  I
HSコード  29399990
有毒物質データの 64-86-8(Hazardous Substances Data)
毒性 LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H300 飲み込むと生命に危険 急性毒性、経口 1, 2 危険 P264, P270, P301+P310, P321, P330,P405, P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H340 遺伝性疾患のおそれ 生殖細胞変異原性 1A, 1B 危険
H371 臓器の障害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P264, P270, P309+P311, P405,P501
注意書き
P201 使用前に取扱説明書を入手すること。
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

コルヒチン 価格 もっと(30)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01BVI1519-1000
Colchicine
64-86-8 1g ¥19300 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00003702 コルヒチン
Colchicine
64-86-8 10mg ¥16500 2018-12-26 購入
東京化成工業 C0380 コルヒチン (≦5%酢酸エチル含む) >97.0%(HPLC)
Colchicine (contains 5% Ethyl Acetate at maximum) >97.0%(HPLC)
64-86-8 500mg ¥6000 2021-03-23 購入
東京化成工業 C0380 コルヒチン (≦5%酢酸エチル含む) >97.0%(HPLC)
Colchicine (contains 5% Ethyl Acetate at maximum) >97.0%(HPLC)
64-86-8 5g ¥34500 2021-03-23 購入
関東化学株式会社(KANTO) 22712-2A コルヒチン 97%
Colchicine 97%
64-86-8 5g ¥78700 2021-03-23 購入

コルヒチン MSDS


Colchicine

コルヒチン 化学特性,用途語,生産方法

外観

白色~わずかにうすい黄色, 結晶性粉末~粉末

溶解性

水に微溶, エタノールに易溶, エーテルに難溶。クロロホルムに可溶、石油エーテルに不溶。エタノールに溶けやすく、水にやや溶けにくく、アセトンに極めて溶けにくい。

解説

C22H25NO6(399.44).ユリ科イヌサフランColchicum autumnaleの種子に多く含まれている(約0.8%),トロポロン核をもった中性アルカロイド."黄色の結晶.融点155 ℃."-121°(クロロホルム).低濃度で植物の染色体倍加作用を有し,4倍体を得ることができるので貴重な薬品である.痛風発作の緩解や予防に有効であるが,中枢神経の麻ひ作用を有し,大量では呼吸麻ひによって死に至る.LD50 1.7 mg/kg(マウス,静注).[CAS 64-86-8]
森北出版「化学辞典(第2版)

用途

チューブリンに特異的に結合 することによって、微小管形成阻害作用を示 します。

用途

チューブリンに特異的に結合 することによって、微小管形成阻害作用を示 します。

用途

同調培養用試薬。

用途

コルヒチン(colchicine)とはイヌサフラン科のイヌサフラン(Colchicum autumnale)の種子や球根に含まれるアルカロイドである。リウマチや痛風の治療に用いられてきたが、毒性も強く下痢や嘔吐などの副作用を伴う。また種なしスイカなどの倍数体植物種の作出にも用いられる。

効能

痛風治療薬, 白血球(好中球)遊走阻害薬, 微小管重合阻害薬

商品名

コルヒチン (高田製薬)

確認試験

(1) 本品のエタノール(95)溶液(1→100000)につき,紫外 可視吸光度測定法〈2.24〉により吸収スペクトルを測定し, 本品のスペクトルと本品の参照スペクトルを比較するとき, 両者のスペクトルは同一波長のところに同様の強度の吸収を 認める.
(2) 本品のメタノール溶液(1→50)0.5mLを赤外吸収スペ クトル用臭化カリウム1gに加え,よくすり混ぜた後,80℃ で1時間減圧乾燥したものにつき,赤外吸収スペクトル測定 法〈2.25〉の臭化カリウム錠剤法により試験を行い,本品の スペクトルと本品の参照スペクトルを比較するとき,両者の スペクトルは同一波数のところに同様の強度の吸収を認める.

定量法

本品約0.4gを精密に量り,無水酢酸25mLに溶かし, 0.05mol/L過塩素酸で滴定〈2.50〉する(電位差滴定法).同様 の方法で空試験を行い,補正する.

純度試験

5mLに塩化鉄(Ⅲ)試液2滴を加えるとき,液は明らかに認め られる緑色を帯びない.
(2) 酢酸エチル及びクロロホルム 本品約0.6gを精密に量 り,内標準溶液2mLを正確に加えて溶かし,更にN,N-ジ メチルホルムアミドを加えて10mLとし,試料溶液とする. 別にN,N-ジメチルホルムアミド約20mLを入れた100mLの メスフラスコを用い,クロロホルム0.30gを量り,N,N-ジ メチルホルムアミドを加えて正確に100mLとする.この液 2mLを正確に量り,N,N-ジメチルホルムアミドを加えて 正確に200mLとし,標準溶液(1)とする.次にN,N-ジメチ ルホルムアミド約20mLを入れた100mLのメスフラスコを用 い,酢酸エチル約1.8gを精密に量り,N,N-ジメチルホルム アミドを加えて正確に100mLとする.この液2mLを正確に 量り,内標準溶液2mLを正確に加え,N,N-ジメチルホル ムアミドを加えて10mLとし,標準溶液(2)とする.試料溶液, 標準溶液(1)及び標準溶液(2)2μLずつを正確にとり,次の条 件でガスクロマトグラフィー〈2.02〉により試験を行う.試 料溶液のクロロホルムのピーク面積は,標準溶液(1)のクロ ロホルムのピーク面積より大きくない.また,試料溶液及び 標準溶液(2)の内標準物質のピーク面積に対する酢酸エチル のピーク面積の比Q T及びQ Sを求める.次式により酢酸エチ ルの量を求めるとき,6.0%以下である.
酢酸エチル(C4H8O2)の量(%)= MS/MT × Q T/Q S × 2
MS:酢酸エチルの秤取量(g)
MT:本品の秤取量(g) 内標準溶液 1-プロパノールのN,N-ジメチルホルムア ミド溶液(3→200)

説明

Colchicine is a pale-yellow powder that is obtained from various species of Colchicum, primarily Colchicum autumnale L. Its total chemical synthesis has been achieved, but the primary source of colchicine currently remains alcohol extraction of the alkaloid from the corm and seed of C. autumnale L. It darkens on exposure to light and possesses

化学的特性

Yellow Solid

化学的特性

Colchicine is a pale yellow powder. It has little or no odor. It darkens on contact with light.

物理的性質

Appearance: colchicine exists in white or light-yellow crystal powder with no smell, and it is seldom prone to absorb moisture. Melting point: it becomes dark when it is exposed to light, and it melts at 87–89?°C. Solubility: this product is soluble in chloroform or ethanol and it dissolves in water. However, the semihydrate crystal can form in certain concentrations. The product is hardly soluble in ether. Specific optical rotation: ?121° (0.9?g/100?mL, chloroform, 589.3?nm, 17?°C).

来歴

Meadow saffron (Colchicum) is recorded to treat rheumatic swelling on ancient Egyptian medical papyrus in 1500 B.C.. According to De Materia Medica written by Pedanius Dioscorides in the first century, extract of Meadow saffron is used in treating gout. London Pharmacopoeia in 1618 recorded that colchicine is also applied to treat gout.
In 1820, the ingredient was first isolated by the French chemist P.S. Pelletier and J.B. Caventou. In 1833, it was purified and named by Geiger. Michael Dewar guessed that there are two seven-membered rings in colchicine in 1945. Murray Vernon King et al. determined the structure of colchicine by X-ray diffraction in 1952. In 1959, Albert Eschenmoser integrated the product successfully
Colchicine tablet and raw material are approved mostly in domestic in 2010. The tablet produced by Taiwan manufacturers is approved for being listed in mainland of China in 2012. The raw material made by Indian obtained the approval in 2013. There are three kinds of colchicine approved by FDA: with the combination of probenecid, it is prior to be approved. The others are tablet (2009) and capsule (2014).

使用

Binds specifically with tubulin thus interfering with microtubule organization.

使用

antimitotic, antigout agent

使用

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and t umor cell lines and activates the JNK/SAPK signaling pathway.

使用

anti-inflammatory agent, mitosis inhibitor

使用

For treatment and relief of pain in attacks of acute gouty arthritis.

使用

In research in plant genetics (for doubling chromosomes).

使用

Colchicine is present in the poisonous autumncrocus (meadow saffron). It is the major alkaloid of Colchicum autumnale L. and Liliaceae. It was used in poison potions in theancient kingdom of Colchis (Greece). It isused therapeutically as an antineoplast, for thesuppression of gout, and in the treatment ofMediterranean fever. It is used in plant studiesfor doubling chromosome groups.

適応症

Colchicine, an alkaloid obtained from the autumn crocus, has long been used and is relatively selective for the treatment of acute gouty arthritis. Unlike many of the newer agents for use in gout, colchicine has minimal effects on uric acid synthesis and excretion; it decreases inflammation associated with this disorder. It is thought that colchicine somehow prevents the release of the chemotactic factors and/or inflammatory cytokines from the neutrophils, and this in turn decreases the attraction of more neutrophils into the affected area .The ability of colchicine to bind to leukocyte microtubules in a reversible covalent complex and cause their depolymerization also may be a factor in decreasing the attraction of the motile leukocytes into the inflamed area.

定義

An alkaloid plant hormone.

定義

colchicine: An alkaloid derivedfrom the autumn crocus, Colchicumautumnale. It inhibits cell division.Colchicine is used in genetics, cytology,and plant breeding research andalso in cancer therapy to inhibit celldivision.

生物学の機能

Acting on polymorphonuclear leukocytes and diminishing phagocytosis, it inhibits the production of lactic acid, causing an increase in the pH of synovial tissue and, thus, a decrease in urate deposition, because uric acid is more soluble at the higher pH. Additionally, colchicine inhibits the release of lysosomal enzymes during phagocytosis that also contributes to the reduction of inflammation. Because colchicine does not lower serum urate levels, it has been found to be beneficial to combine colchicine with a uricosuric agent, particularly probenecid. It is a potent drug, being effective at doses of approximately 1 mg, but doses as small as 7 mg have caused fatalities.

一般的な説明

Colchicine is an alkaloid isolated from the dried corns andseeds of Colchicum autumnale L., commonly known as autumncrocus or meadow saffron.It is specifically indicated for acute treatment of goutyarthritis because of its ability to block the production and releaseof the CCF that mediates the inflammatory responsebecause of urate crystals, a mechanism different fromcolchicine’s antimitotic action, which is being investigatedfor its anticancer properties. It is often quite effective inaborting an acute gouty attack if given within the first 10 to12 hours after the onset of arthritis.

一般的な説明

Odorless or nearly odorless pale yellow needles or powder that darkens on exposure to light. Used to treat gouty arthritis, pseudogout, sarcoidal arthritis and calcific tendinitis.

空気と水の反応

Slowly hydrolyzed in acidic solution, but unbuffered solutions are stable at 68°F for at least six months. Isomerizes on exposure to ultraviolet radiation.

反応プロフィール

Colchicine darkens on exposure to light. Incompatible with strong oxidizing agents. Also incompatible with mineral acids .

危険性

As little as 20 mg may be fatal if ingested.

健康ハザード

Colchicine is a highly toxic alkaloid. Thetarget organs are the lungs, kidney, gastrointestinal tract, and blood. The toxiceffects include drowsiness, nausea, hypermotility, diarrhea, lowering of body temperature, lowering of blood pressure, tremors,convulsions, and respiratory distress. Chronicingestion may cause aplastic anemia andhemorrhage.
LD50 value, oral (mice): 5.9 mg/kg
Colchicine solution at 10,000 ppm concentration caused severe irritation whenapplied repeatedly to rabbits’ eyes. Colchicine produced teratogenic effects in testanimals. It caused fetal death, cytologicalchanges, and developmental abnormalitiesin hamsters, rabbits, domestic animals,and mice. It tested positive to in vitromammalian nonhuman micronucleus andD. melanogaster — nondisjunction tests formutagenicity (U.S. EPA 1986; NIOSH1986).

健康ハザード

Colchicine is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg, i.e. less than 7 drops for a 70 kg (150 lb.) person. Death results from respiratory arrest. The fatal dose varies considerably; as little as 7 mg of Colchicine has proved fatal.

火災危険

Stable.

生物活性

Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.

Biochem/physiol Actions

Colchicine interacts with albumin and binds to tubulin. Its association with tubulin impacts autophagic vacuole fusion with lysosomes. It inhibits tyrosine kinases and phospholipases. Colchicine may be useful for treating acute coronary syndromes. It is prescribed for treating rheumatologic conditions including familial mediterranean fever (FMF) and acute gouty arthritis.

作用機序

Colchicine is rapidly absorbed after oral administration and tends to concentrate in the spleen, kidney, liver, and gastrointestinal tract. Leukocytes also avidly accumulate and store colchicine even after a single intravenous injection. Since colchicine can accumulate in cells against a concentration gradient, it is postulated that an active transport process may be involved in its cellular uptake. The drug is metabolized, primarily in the liver, by deacetylation. Fecal excretion plays a major role in colchicine elimination, since it and its metabolites are readily secreted into the bile. Only about 15 to 30% of the drug is eliminated in the urine except in patients with liver disease; urinary excretion is more important in these individuals.

薬物動態学

Colchicine is absorbed on oral administration, with peak plasma levels being attained within 0.5 to 2 hours after dosing. Plasma protein binding is only 31%. It concentrates primarily in the intestinal tract, liver, kidney, and spleen and is excreted primarily in the feces, with only 20% of an oral dose being excreted in the urine. It is retained in the body for considerable periods of time, being detected in the urine and leukocytes for 9 to 10 days following a single dose.

薬理学

The drug can be given intravenously as well as orally, but care must be exercised, since extravasated drug may result in local sloughing of skin and subcutaneous tissues. Relief of pain and inflammation usually occurs within 48 hours. Small doses of colchicine can be used during asymptomatic periods to minimize the reappearance or severity of acute attacks. It should be used with caution in patients with preexisting compromised heart, kidney, gastrointestinal tract, and liver disease. Diarrhea, nausea, vomiting, and abdominal pain are the major limiting side effects that ultimately determine the tolerated dosage. These symptoms occur in approximately 80% of patients who take colchicine, especially in those taking high dosages. The hepatobiliary recycling of colchicine and its antimitotic effect on cells that are rapidly turning over, such as those of the intestinal epithelium, account for its gastrointestinal toxicity. Gastrointestinal symptoms generally intervene before the appearance of more serious toxicity and thereby provide a margin of safety in drug administration. Ingestion of large doses of colchicine may be followed by a burning sensation in the throat, bloody diarrhea, shock, hematuria, oliguria, and central nervous system (CNS) depression.

抗がん研究

It is a natural toxic secondary metabolite, extracted from Colchicum genus plants. Itprevents gastric cancer by upregulating the dual specificity phosphatase 1 (DUSP1)gene. It is also reported to upregulate transforming growth factor beta 2 (TGF-β2)and A-kinase anchoring protein 12 (AKAP12) in hepatocellular carcinoma (Singhet al. 2016b).

臨床応用

The major use of colchicine is as an antiinflammatory agent in the treatment of acute gouty arthritis; it is not effective in reducing inflammation in other disorders. It also can be used to prevent attacks. Since colchicine is so rapidly effective in relieving the acute symptoms of gout (substantial improvement is achieved within hours), it has been used as a diagnostic aid in this disorder. Therapy with colchicine is usually begun at the first sign of an attack and is continued until symptoms subside, adverse gastrointestinal reactions appear, or a maximum dose of 6 to 7 mg has been reached.

副作用

Colchicine may produce bone marrow depression, with long-term therapy resulting in thrombocytopenia or aplastic anemia. At maximum dose levels, GI disturbances (e.g., nausea, diarrhea, and abdominal pain) may occur. Acute toxicity is characterized by GI distress, including severe diarrhea resulting in excessive fluid loss, respiratory depression, and kidney damage. Treatment normally involves measures that prevent shock as well as morphine and atropine to diminish abdominal pain. A number of drug interactions have been reported. In general, the actions of colchicine are potentiated by alkalinizing substances and are inhibited by acidifying drugs, consistent with its mechanism of action of increasing the pH of synovial fluid. Responses to CNS depressants and to sympathomimetic drugs appear to be enhanced. Clinical tests may be affected; most notably, elevated alkaline phosphatase and SGOT (serum glutamate oxaloacetate transaminase) values and decreased thrombocyte values may be obtained.

安全性プロファイル

experimentally by most routes. Human systemic effects: aplastic anemia, blood pressure depression, body temperature decrease, changes in kidney tubules, dyspnea, flaccid paralysis without anesthesia, gastrointestinal effects, kidney damage and hemorrhaging, muscle contraction or spasticity, muscle weakness, nausea or vomiting, respiratory stimulation, and somnolence. An experimental teratogen. Experimental reproductive effects. A severe eye irritant. Human mutation data reported. Inhibits the formation of microtubules and thus impairs cell division. When heated to decomposition it emits toxic fumes of NOx.

職業ばく露

Colchicine is a drug used to treat gouty arthritis, pseudogout, sarcoidal arthritis; and calcific tendonitis.

Veterinary Drugs and Treatments

In veterinary medicine, colchicine has been proposed as a treatment in small animals for amyloidosis. For colchicine to be effective, however, it must be given early in the course of the disease and it will be ineffective once renal failure has occurred. At the time of writing, no conclusive evidence exists for its efficacy for this indication in dogs.
Colchicine has also been proposed for treating chronic hepatic fibrosis presumably by decreasing the formation and increasing the breakdown of collagen.

環境運命予測

Colchicine binds to tubulin and prevents its polymerization into microtubules, subsequently disrupting microtubule function. Consequently, it alters nuclear structure, intracellular transport, and cytoplasmic motility, ultimately causing cell death. Colchicine is a potent inhibitor of cellular mitosis.

代謝

Metabolism occurs primarily in the liver, with the major metabolite being the amine resulting from amide hydrolysis.

輸送方法

UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

純化方法

Commercial material contains up to 4% desmethylcolchicine. Purify colchicine by chromatography on alumina and eluting with CHCl3 [Ashley & Harris J Chem Soc 677 1944]. Alternatively, an acetone solution on alkali-free alumina has been used, and eluting with acetone [Nicholls & Tarbell J Am Chem Soc 75 1104 1953]. It crystallises as yellow needles from EtOAc or CHCl3 with solvent of crystallisation which can be removed at ~70o. It is soluble in Et2O (0.5%), *C6H6 (1%) and H2O (4%). It is sold as “Colgout” for the treatment of gout and binds to tubulin. [Schreiber et al. Helv Chim Acta 44 540 1961, Scott et al. Tetrahedron 21 3605 1965, van Tamelen et al. Tetrahedron 14 8 1961, Beilstein 14 IV 946.]

Toxicity evaluation

No information is currently available on breakdown in soil, groundwater, or surface water. Colchicine alkaloids withstand storage, drying, and boiling.
Ingestion is the most common route of both accidental and intentional exposure to colchicine. It is available as an oral tablet and solution for injection.

不和合性

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, mineral acids. Keep away from light.

コルヒチン 上流と下流の製品情報

原材料

準備製品


コルヒチン 生産企業

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64-86-8(コルヒチン )キーワード:

(13aR)-5,8,13,13a-テトラヒドロ-2,3,9,10-テトラメトキシ-6H-ジベンゾ[a,g]キノリジン (7aα,13aβ,13bα,13cα)-2,3,6,7,7a,12,13,13a,13b,13c-デカヒドロ-1H,5H,8H-ジピリド[2,1-f:3',2',1'-ij][1,6]ナフチリジン-10(11H)-オン 3-[4-(β-D-グルコピラノシルオキシ)フェニル]-5,7-ジヒドロキシ-4H-1-ベンゾピラン-4-オン 2,6-ジメチル-7-オクテン-2-オール コルヒチン (S)-7-アミノ-6,7-ジヒドロ-10-ヒドロキシ-1,2,3-トリメトキシベンゾ[a]ヘプタレン-9(5H)-オン 4-ニトロ-N-[(S)-5,6,7,9-テトラヒドロ-1,2,3,10-テトラメトキシ-9-オキソベンゾ[a]ヘプタレン-7-イル]ベンズアミド (S)-7-[(α-L-アラビノピラノシル)アミノ]-6,7-ジヒドロ-1,2,3-トリメトキシ-10-(メチルチオ)ベンゾ[a]ヘプタレン-9(5H)-オン (S)-6-(アセチルアミノ)-4,6,7,8-テトラヒドロ-3,13-ジメトキシヘプタレノ[1,2-f][1,3]ベンゾジオキソール-4-オン (S)-6,7-ジヒドロ-1,2,3-トリメトキシ-10-(メチルチオ)-7-(2-O,3-O,4-O,6-O-テトラアセチル-β-D-グルコピラノシルアミノ)ベンゾ[a]ヘプタレン-9(5H)-オン (7S)-1,2,3,10-テトラメトキシ-7α-(メチルアミノ)-5,6-ジヒドロベンゾ[a]ヘプタレン-9(7H)-オン N-[(7S)-5,6,7,9-テトラヒドロ-10-ヒドロキシ-1,2,3-トリメトキシ-9-オキソベンゾ[a]ヘプタレン-7-イル]アセトアミド コルヒチン·ヒドリドよう素 (S)-7-(β-D-グルコピラノシルアミノ)-6,7-ジヒドロ-1,2,3-トリメトキシ-10-(メチルチオ)ベンゾ[a]ヘプタレン-9(5H)-オン メタンチオスルホン酸コルヒチン (S)-7-アセチルアミノ-6,7-ジヒドロ-3-(β-D-グルコピラノシルオキシ)-1,2,10-トリメトキシベンゾ[a]ヘプタレン-9(5H)-オン N-[(S)-5,6,7,9-テトラヒドロ-1,2,3,10-テトラメトキシ-9-オキソベンゾ[a]ヘプタレン-7-イル]-N-メチルアセトアミド コルヒチン-D6

  • 64-86-8
  • (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE
  • N-((S)-1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL)-ACETAMIDE
  • n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide
  • Colchicine Acetamide 64-86-8
  • Colchicine 64-86-8
  • len-7-yl)-
  • N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
  • n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-acetamid
  • n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-acetamid
  • N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-Acetamide
  • n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamid
  • N-Acetyl trimethylcolchicinic acid methylether
  • n-acetyltrimethylcolchicinicacidmethylether
  • NSC 757
  • Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-
  • tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-
  • COLCHICINE extrapure
  • Colchicine99%
  • (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[alpha]heptalen-7-yl)acetamide
  • (-)-N-[(S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
  • Colchicine, 95% (dry wt.), may cont. up to 2% water and 8% ethyl acetate
  • Colchicine,97%
  • (S)-Colchicine >95%
  • COLCHICINE CRYST. RESEARCH GRADE
  • Colchicine (350 mg)
  • Colchlcine
  • Colchicine, 97% 500MG
  • Colchicine (dry wt.), may cont. up to 2% water and 8% ethyl acetate
  • 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5h)-one
  • ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL-, (S)
  • コルヒチン (≦5%酢酸エチル含む)
  • (7S)-1,2,3,10-テトラメトキシ-7α-(アセチルアミノ)-5,6,7,9-テトラヒドロベンゾ[a]ヘプタレン-9-オン
  • コルチシン
  • (7S)-(-)-コルヒチン
  • N-[[(7S)-1,2,3,10-テトラメトキシ-9-オキソ-5,6,7,9-テトラヒドロベンゾ[a]ヘプタレン]-7α-イル]アセトアミド
  • コルヒネオス
  • コルキシン
  • (7S)-コルキシン
  • コルヒチン
  • (S)-7α-アセチルアミノ-6,7-ジヒドロ-1,2,3,10-テトラメトキシベンゾ[a]ヘプタレン-9(5H)-オン
  • (7S)-5,6,7,9-テトラヒドロ-1,2,3,10-テトラメトキシ-9-オキソ-N-アセチルベンゾ[a]ヘプタレン-7α-アミン
  • (S)-7-アセチルアミノ-6,7-ジヒドロ-1,2,3,10-テトラメトキシベンゾ[a]ヘプタレン-9(5H)-オン
  • (-)-コルヒチン
  • コンディロン
  • コルチセインメチルエーテル
  • コルチネオス
  • N-[[(S)-1,2,3-トリメトキシ-9-オキソ-10-メトキシ-5,6,7,9-テトラヒドロベンゾ[a]ヘプタレン]-7α-イル]アセトアミド
  • コルヒソール
  • (-)-コルキシン
  • コルサロイド
  • コルチン
  • (-)-N-[(S)-5,6,7,9-テトラヒドロ-1,2,3,10-テトラメトキシ-9-オキソベンゾ[a]ヘプタレン-7-イル]アセトアミド
  • (S)-N-(1,2,3,10-テトラメトキシ-9-オキソ-5,6,7,9-テトラヒドロベンゾ[a]ヘプタレン-7-イル)アセトアミド
  • コルチシン(コルヒチン)
  • コルヒチン (JP17)
  • トロポロン
  • トロポロン & アズレン
  • 構造分類
  • 生化学
  • 植物生長調節物質
  • 植物生長調節物質 (その他)
  • アルカロイド
  • アルカロイド (その他)
  • 染色体倍加剤
  • 痛風治療薬
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