N-メチル-D-グルカミン 化学特性,用途語,生産方法
外観
白色～ほとんど白色, 結晶性粉末～粉末又は塊
定義
本品は、次の化学式で表される有機化合物である。
溶解性
水に易溶、メタノール, エタノールに難溶、クロロホルム, エーテルに不溶。
用途
イオン交換、キレート樹脂原料。有機合成原料。
化粧品の成分用途
pH調整剤
効能
診断補助薬 (放射線不透過性造影剤)
化学的特性
Meglumine occurs as a white to slightly yellow-colored crystalline
powder; it is odorless or with a slight odor.
使用
N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.
調製方法
Meglumine is prepared by the imination of glucose and monomethylamine,
in an alcoholic solution, followed by catalytic
hydrogenation.
定義
ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi
e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
一般的な説明
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.
応用例（製薬）
Meglumine is an organic base used as a pH-adjusting agent and
solubilizing agent, primarily in the preparation of soluble salts of
iodinated organic acids used as X-ray contrast media.
安全性
Meglumine is widely used in parenteral pharmaceutical formulations
and is generally regarded as a nontoxic material at the levels
usually employed as an excipient.
LD
50 (mouse, IP): 1.68 g/kg
貯蔵
Meglumine does not polymerize or dehydrate unless heated above
150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a
cool, dry place. Meglumine should not be stored in aluminum
containers since it reacts to evolve hydrogen gas; it discolors if
stored in containers made from copper or copper alloys. Stainless
steel containers are recommended.
純化方法
Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
不和合性
Incompatible with aluminum, copper, mineral acids, and oxidizing
materials. Differential scanning calorimetry studies suggest meglumine
is incompatible with glipizide.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (injections; oral
tablets). Included in parenteral medicines licensed in the UK.
N-メチル-D-グルカミン 上流と下流の製品情報
原材料
準備製品