セフチオフルナトリウム塩

セフチオフルナトリウム塩 化学構造式
104010-37-9
CAS番号.
104010-37-9
化学名:
セフチオフルナトリウム塩
别名:
セフチオフルナトリウム塩;セフチオフルナトリウム;セフチオフルナトリウム (JAN);ナトリウム (6R,7R)-7-[(2Z)-2-(2-アミノ-1,3-チアゾール-4-イル)-2-(メトキシイミノ)アセトアミド]-3-[(フラン-2-カルボニルスルファニル)メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボキシラート;(6R,7R)-7-[[[2-アミノ-4-チアゾリル][(Z)-メトキシイミノ]アセチル]アミノ]-3-[[(2-フラニルカルボニル)チオ]メチル]セファム-3-エン-4-カルボン酸ナトリウム;(6R,7R)-7-[[[2-アミノ-4-チアゾリル][(Z)-メトキシイミノ]アセチル]アミノ]-3-[[(2-フラニルカルボニル)チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸ナトリウム
英語名:
Ceftiofur sodium
英語别名:
monos;SODIUM CEFTIOFUR;ceftiofur sodium salt;5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-3-(2-furanylcarbonyl)thiomethyl-8-oxo-, monosodium salt, (6R,7R)-;(6R,7R)-7-((Z)-2-(2-AMinothiazol-4-yl)-2-(MethoxyiMino)acetaMido)-3-(((furan-2-carbonyl)thio)Methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodiuM salt;(6R-(6alpha,7beta(Z))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;naxcel;u-64279e;Ceftiofur Sodic;CEFTIOFUR SODIUM
CBNumber:
CB6443197
化学式:
C19H18N5NaO7S3
分子量:
547.55
MOL File:
104010-37-9.mol

セフチオフルナトリウム塩 物理性質

融点 :
>185°C (dec.)
RTECS 番号:
XI0367360
貯蔵温度 :
under inert gas (nitrogen or Argon) at 2–8 °C
溶解性:
水溶液に溶けやすい
外見 :
個体
色:
ペールイエロー
InChIKey:
RFLHUYUQCKHUKS-JUODUXDSSA-M
SMILES:
C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC(C1OC=CC=1)=O)(=O)O.[NaH] |&1:5,7,r|
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
WGK Germany  3
HSコード  2941906000
絵表示(GHS) GHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ 感作性、呼吸器 1 危険 GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H413 長期的影響により水生生物に有害のおそれ 水生環境有害性、慢性毒性 4
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P284 呼吸用保護具を着用すること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P342+P311 呼吸に関する症状が出た場合:医師に連絡すること。

セフチオフルナトリウム塩 価格 もっと(17)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-0568 セフチオフルナトリウム
Ceftiofur sodium
104010-37-9 1g ¥10000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-0568 セフチオフルナトリウム
Ceftiofur sodium
104010-37-9 5g ¥20000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-0568 セフチオフルナトリウム
Ceftiofur sodium
104010-37-9 10g ¥30000 2024-03-01 購入
Sigma-Aldrich Japan PHR1521 Pharmaceutical Secondary Standard; Certified Reference Material
Ceftiofur Sodium Pharmaceutical Secondary Standard; Certified Reference Material
104010-37-9 1g ¥17800 2024-03-01 購入
Sigma-Aldrich Japan 1098165 セフチオフル ナトリウム塩 三水和物 United States Pharmacopeia (USP) Reference Standard
Ceftiofur sodium trihydrate United States Pharmacopeia (USP) Reference Standard
104010-37-9 100mg ¥58400 2024-03-01 購入

セフチオフルナトリウム塩 化学特性,用途語,生産方法

効能

抗生物質 (獣医薬), 細胞壁合成阻害薬

説明

Ceftiofur sodium is the sodium salt of ceftiofur, which belongs to the third generation cephalosporin antibiotics, for the first time in 1988 it was listed in the United States. Chemical properties are stabie, appearance is light yellow to white crystalline powder, aqueous solution has a shorter retention time, it should be diluted into a solution before use.
Ceftiofur has a broad antimicrobial spectrum , it has a strong antibacterial activity, it has a strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria ,its antibacterial activity is similar to or weaker than the first-generation cephalosporins against Gram-positive bacteria, it has a strong antibacterial activity against Gram-negative bacteria such as E. coli, Salmonella, Pasteurella and so on. It is used for a variety of respiratory, urinary tract and other infections caused by sensitive bacteria, especially for the prevention and treatment of early death of chicks caused by E. coli, Salmonella, Pseudomonas aeruginosa, Staphylococcus aureus , E. coli yellow dysentery of 1 piglets and wound infections caused by cutting the umbilical cord, ear numbers, cutting teeth, tails and others,pleuropneumoniae and bovine bronchial pneumonia caused by Haemophilus and Actinobacillus, generally it does not apply to cows and goats mastitis treatment . Some researchers have done ceftiofur sodium inhibition tests for thousands strains of pathogens isolated by veterinary clinically, the results show that the drug is one of the most active anti-bacterial drugs, it has a strong antibacterial activity against Escherichia coli, p.multocida and p.haemolytica ,Bacillus typhosus, Streptococcus ; it also has a good effect on Pseudomonas aeruginosa, Enterobacter, anaerobic bacteria. It is used for the treatment of respiratory disease of sheep,horses, cattle, pigs (pleuropneumonia),and the treatment of pets, day-old broiler infectious diseases. This product has characteristics such as complete intramuscular absorption and long elimination half-life period.
The above information is edited by the chemicalbook of Tian Ye.

化学的特性

White or light yellow crystalline powder

使用

Ceftiofur sodium is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported. The bactericidal activity of ceftiofur results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins. The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall component from being properly synthesized.

適応症

Ceftiofur sodium is a third-generation broad-spectrum cephalosporin (β-lactam antibiotic) which is effective against Gram-positive, Gram-negative, anaerobic, and β-lactamase producing bacteria. It belongs to antibiotic medicines for the treatment of swine bacterial respiratory infection.

brand name

Naxcel

副作用

Adverse reactions to Ceftiofur sodium are rare with intramuscular antimicrobial treatment with ceftiofur hydrochloride at a dose of 2.2 mg/kg. During the first day, the mare showed no signs of drug side effects. However, 24 hours later, during the second application, the patient developed incoordination, dizziness and loss of balance. At the same time, dexamethasone was given. Signs returned and the mare returned to normal after the reaction. Treatment with ceftiofur was changed to enrofloxacin and the animal recovered completely. These drug reactions are not common in the day-to-day work of equine clinical practitioners, but they are of great concern to owners and veterinarians[1].

Veterinary Drugs and Treatments

Labeled indications for ceftiofur sodium:
In cattle for treatment of bovine respiratory disease (shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. It is also indicated for treatment of acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
In swine for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.
In sheep/goats for treatment of sheep/caprine respiratory disease (sheep/goat pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
In horses for treatment of respiratory infections in horses associated with Streptococcus zooepidemicus. In dogs for the treatment of canine urinary tract infections associated with E. coli and Proteus mirabilis.
In day old chicks/poults for the control of early mortality, associated with E. coli organisms susceptible to ceftiofur.
Ceftiofur sodium has also been used in an extra-label manner in a variety of veterinary species (see Doses) to treat infections that likely to be susceptible to a 3rd generation cephalosporin.

セフチオフルナトリウム塩 上流と下流の製品情報

原材料

準備製品


セフチオフルナトリウム塩 生産企業

Global( 417)Suppliers
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セフチオフルナトリウム塩  スペクトルデータ(1HNMR)


104010-37-9(セフチオフルナトリウム塩)キーワード:


  • 104010-37-9
  • naxcel
  • u-64279e
  • CEFTIOFUR SODIUM
  • Ceftiofur Sodium (100 mg)
  • Ceftiofur sodium trihydrate
  • 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl
  • 7-beta(z))-odiumsalt(6r-(6-alph
  • Ceftiofur SodiumQ: What is Ceftiofur Sodium Q: What is the CAS Number of Ceftiofur Sodium Q: What is the storage condition of Ceftiofur Sodium Q: What are the applications of Ceftiofur Sodium
  • Ceftiofur Sodium (1098082)
  • Ceftiofur Sodic
  • Ceftiofur (As Ceftiofur Sodic)
  • Ceftiofur-d3 Sodium Salt
  • Ceftiofur Sodium for injection
  • Ceftiofursodiumsal
  • Ceftiofur sodium USP/EP/BP
  • Sodium ceftiofur,Ceftiofur sodium
  • (6R-(6alpha,7beta(Z))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • ceftiofur sodium salt
  • SODIUM CEFTIOFUR
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-3-(2-furanylcarbonyl)thiomethyl-8-oxo-, monosodium salt, (6R,7R)-
  • (6R,7R)-7-((Z)-2-(2-AMinothiazol-4-yl)-2-(MethoxyiMino)acetaMido)-3-(((furan-2-carbonyl)thio)Methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodiuM salt
  • monos
  • Cefotaxifur sodium
  • Cefotaxifur sodium (solvent method, sterile)
  • セフチオフルナトリウム塩
  • セフチオフルナトリウム
  • セフチオフルナトリウム (JAN)
  • ナトリウム (6R,7R)-7-[(2Z)-2-(2-アミノ-1,3-チアゾール-4-イル)-2-(メトキシイミノ)アセトアミド]-3-[(フラン-2-カルボニルスルファニル)メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボキシラート
  • (6R,7R)-7-[[[2-アミノ-4-チアゾリル][(Z)-メトキシイミノ]アセチル]アミノ]-3-[[(2-フラニルカルボニル)チオ]メチル]セファム-3-エン-4-カルボン酸ナトリウム
  • (6R,7R)-7-[[[2-アミノ-4-チアゾリル][(Z)-メトキシイミノ]アセチル]アミノ]-3-[[(2-フラニルカルボニル)チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸ナトリウム
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