アズロシリン 化学特性,用途語,生産方法
効能
抗生物質, 細胞壁合成阻害薬
使用
Antibacterial.
定義
ChEBI: A semisynthetic penicillin antibiotic used in treating infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.
適応症
Azlocillin is active with respect to Gram-positive and Gram-negative aerobic and anaerobic microorganisms. It is highly effective with respect to bacillus pyocyaneus, including
strains that are resistant to carbenicillin and aminoglycosides. It is destroyed by betalactamases. It is used for bacterial infections such as pyelonephritis, uretritis, cystitis,
endometritis, cholecystitis, sepsis, peritonitis, endocarditis, meningitis, pneumonia, infections of the skin and soft tissues, infected burns, and so on. Synonyms of this drug are
securopen and azlin.
抗菌性
A semisynthetic acylureidopenicillin supplied as the sodium
salt for parenteral administration. It is active against a wide
range of other Gram-negative bacteria, but is distinguished
mainly by its activity against Ps. aeruginosa. B.
fragilis and other anaerobes are moderately susceptible. Like
other ureidopenicillins, azlocillin is active against Grampositive
cocci, H. influenzae and N. gonorrhoeae. Because it can
be hydrolyzed by most β-lactamases, β-lactamase-producing
isolates are resistant.
It attains peak concentrations of 250 mg/L after a 3 g intravenous
infusion, with a plasma half-life of approximately 1 h.
Protein binding is 20–30%. It distributes into multiple tissues
and human body fluids at therapeutically useful concentrations.
Up to 60% of the dose is recoverable from the urine,
mostly unchanged, although some hydrolysis of the β-lactam
ring takes place in the body.
Toxicity and side effects are similar to those associated
with carboxypenicillins. Its clinical use is for serious infections
with susceptible organisms, including lower respiratory tract,
intra-abdominal, urinary tract and gynecological infections.
Commercial availability is quite limited.
アズロシリン 上流と下流の製品情報
原材料
準備製品