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チモール

チモール 化学構造式
89-83-8
CAS番号.
89-83-8
化学名:
チモール
别名:
チモール;2-イソプロピル-5-メチルフェノール;6-イソプロピル-m-クレゾール;5-メチル-2-イソプロピルフェノール;m-チモール;6-イソプロピル-3-メチルフェノール;3-ヒドロキシ-p-シメン;チムカンファー;5-メチル-2-(1-メチルエチル)フェノール;チモ-ル;6イソプロピルmクレゾル;チモール標準品;チモール、噴霧試液用
英語化学名:
Thymol
英語别名:
TB;THYMOL;S NO 879;m-Thymol;THYMOLUM;FEMA 3066;thymicacid;Metathymol;THYMOL(SG);Thymic acid
CBNumber:
CB6672399
分子式:
C10H14O
分子量:
150.22
MOL File:
89-83-8.mol

チモール 物理性質

融点 :
48-51 °C(lit.)
沸点 :
232 °C(lit.)
比重(密度) :
0.965 g/mL at 25 °C(lit.)
蒸気圧:
1 mm Hg ( 64 °C)
FEMA :
3066 | THYMOL
屈折率 :
nD20 1.5227; nD25 1.5204
闪点 :
216 °F
貯蔵温度 :
Store at RT.
溶解性:
ethanol: soluble50mg/mL
外見 :
Crystals or Crystalline Powder
色:
White
水溶解度 :
0.1 g/100 mL (20 ºC)
Merck :
14,9399
BRN :
1907135
安定性::
Stable. Incompatible with strong oxidizing agents, organic materials, strong bases.
CAS データベース:
89-83-8(CAS DataBase Reference)
NISTの化学物質情報:
Phenol, 5-methyl-2-(1-methylethyl)-(89-83-8)
EPAの化学物質情報:
Phenol, 5-methyl-2-(1-methylethyl)- (89-83-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  C,N
Rフレーズ  22-34-51/53
Sフレーズ  26-28-36/37/39-45-61-28A
RIDADR  UN 3261 8/PG 3
WGK Germany  2
RTECS 番号 XP2275000
TSCA  Yes
国連危険物分類  8
容器等級  III
HSコード  29071900
有毒物質データの 89-83-8(Hazardous Substances Data)
毒性 LD50 orally in rats: 980 mg/kg (Jenner)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H401 水生生物に毒性 水生環境有害性、急性毒性 2 P273, P501
H411 長期的影響により水生生物に毒性 水生環境有害性、慢性毒性 2
注意書き
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P330+P331 飲み込んだ場合:口をすすぐこと。無理に吐かせ ないこと。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P405 施錠して保管すること。

チモール 価格 もっと(44)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00020295 チモール
Thymol
89-83-8 100mg ¥10100 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00020295 チモール
Thymol
89-83-8 1g ¥23500 2018-12-26 購入
東京化成工業 M0410 チモール >99.0%(GC)
Thymol >99.0%(GC)
89-83-8 25g ¥1600 2018-12-04 購入
東京化成工業 M0410 チモール >99.0%(GC)
Thymol >99.0%(GC)
89-83-8 500g ¥8400 2018-12-04 購入
関東化学株式会社(KANTO) 15033-3A チモール
Thymol
89-83-8 100g ¥3300 2018-12-13 購入

チモール 化学特性,用途語,生産方法

外観

白色, 結晶~結晶性粉末

定義

本品は、フェノール(*)の誘導体であり、次の化学式で表される。
参照表示名称:フェノール

溶解性

水に殆ど不溶。エタノール, アセトンに易溶。エタノール及びアセトンに溶けやすく、水にほとんど溶けない。

用途

駆虫薬 抗細菌薬 殺菌薬 歯科用薬、香料、フレバーの原料成分、ラベンダーの香気成分

用途

防腐剤、殺菌剤、調製液原料、分析用(発色試薬)、有機合成原料。

化粧品の成分用途

変性剤、口腔衛生剤、香料

化学的特性

Thymol occurs as colorless or often large translucent crystals, or as a white crystalline powder with a herbal odor (aromatic and thymelike) and a pungent caustic taste.

化学的特性

white crystals or powder with a pungent odour

使用

Thymol is an antimicrobial compound which can increase the efficacy of antibiotics involving drug resistant bacteria. It inhibits growth and lactate production as well as reduces cellular glucose upta ke within the bacteria.

調製方法

Thymol is obtained from the volatile oil of thyme (Thymus vulgaris Linne′ (Fam. Labiatae)) by fractional distillation followed by extraction and recrystallization. Thyme oil yields about 20–30% thymol. Thymol may also be produced synthetically from pcymene, menthone, or piperitone, or by the interaction of m-cresol with isopropyl chloride.

応用例(製薬)

Thymol is a phenolic antiseptic, which has antibacterial and antifungal activity. However, it is not suitable for use as a preservative in pharmaceutical formulations because of its low aqueous solubility. The antimicrobial activity of thymol against eight oral bacteria has been studied in vitro. Inhibitory activity was noted against almost all organisms, and a synergistic effect was observed for combinations of thymol and eugenol, and of thymol and carvacrol. The activity of thymol against bacteria commonly involved in upper respiratory tract infections has also been shown.
Thymol is a more powerful disinfectant than phenol, but its low water solubility, its irritancy to tissues, and its inactivation by organic material, such as proteins, limit its use as a disinfectant. Thymol is chiefly used as a deodorant in antiseptic mouthwashes, gargles, and toothpastes, such as in Compound Thymol Glycerin BP, in which it has no antiseptic action.
Thymol is also a true antioxidant and has been used at concentrations of 0.01% as an antioxidant for halothane, trichloroethylene, and tetrachloroethylene. The antioxidant activity of thymol and thymol analogues has been described. More recently, thymol has been shown to enhance the in vitro percutaneous absorption of a number of drugs, including 5- fluorouracil, piroxicam, propranolol, naproxen, and tamoxifen. Studies have also demonstrated that the melting point of lidocaine is significantly lowered when it is mixed with thymol.
The inhalation of thymol, in combination with other volatile substances, is used to alleviate the symptoms of colds, coughs, and associated respiratory disorders. Externally, thymol has been used in dusting powders for the treatment of fungal skin infections; thymol has been shown to have synergistic antifungal effects when combined with ketoconazole. Thymol was formerly used in the treatment of hookworm infections but has now been superseded by less toxic substances.
In dentistry, thymol has been mixed with phenol and camphor to prepare cavities before filling, and mixed with zinc oxide to form a protective cap for dentine.
Thymol has been included in food, perfume, and cosmetic products, and has also been used as a pesticide and fungicide.

安全性プロファイル

Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. Mutation data reported. An allergen. Incompatible with acetanilide. When heated to decomposition it emits acrid smoke and irritating fumes. An FDA over-the-counter drug used as an antibacterial and antifungal agent.

安全性

Thymol is used in cosmetics, foods, and pharmaceutical applications as an excipient. However, thymol may be irritating when inhaled or following contact with the skin or eyes. It may also cause abdominal pain and vomiting, and sometimes stimulation followed by depression of the central nervous system following oral consumption; fats and alcohol increase absorption and aggravate symptoms.
Respiratory arrest, attributed to acute nasal congestion and edema, has been reported in a 3-week-old patient due to the erroneous intranasal application of Karvol, a combination product that includes thymol. The patient recovered, but it was recommended that inhalation decongestants should not be used in children under the age of 5 years.
LD50 (guinea pig, oral): 0.88 g/kg
LD50 (mouse, IP): 0.11 g/kg
LD50 (mouse, IV): 0.1 g/kg
LD50 (mouse, oral): 0.64 g/kg
LD50 (mouse, SC): 0.243 g/kg
LD50 (rat, oral): 0.98 g/kg

貯蔵

Thymol should be stored in well-closed, light-resistant containers, in a cool, dry, place. Thymol is affected by light.

不和合性

Thymol is incompatible with iodine, alkalis, and oxidizing agents. It liquefies, or forms soft masses, on trituration with acetanilide, antipyrine, camphor, monobromated camphor, chloral hydrate, menthol, phenol, or quinine sulfate. The antimicrobial activity of thymol is reduced in the presence of proteins.

規制状況(Regulatory Status)

GRAS listed. Included in the FDA Inactive Ingredients Database (inhalation, liquid; oral, powder for solution). Included in nonparenteral medicines (topical creams and ointments) licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

チモール 上流と下流の製品情報

原材料

準備製品


チモール 生産企業

Global( 359)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1659 55
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001
peter@hubeijusheng.com CHINA 18004 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4525 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 744 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 10967 58

89-83-8(チモール)キーワード:


  • 89-83-8
  • Thymic acid
  • thymicacid
  • 6-ISOPROPYL-3-METHYLPHENOL
  • 6-ISOPROPYL-M-CRESOL
  • 5-METHYL-2-ISOPROPYLPHENOL
  • 5-METHYL-2-(1-METHYLETHYL)PHENOL
  • 3-HYDROXY-P-CYMENE
  • 1-METHYL-3-HYDROXY-4-ISOPROPYLBENZENE
  • 2-ISOPROPYL-5-METHYLPHENOL
  • LABOTEST-BB LT00454334
  • FEMA 3066
  • 5-Methy-2-iso-propyl-l-phenol
  • THYMOL CRYSTALS
  • Metathymol
  • THYMOL 99+% FCC
  • THYMOL EXTRA PURE, DAB, PH. EUR., B.P., N. F., PH. FRANC.
  • THYMOL, PH EUR
  • THYMOL CRYSTALLINE
  • Thymol,>99%
  • ThymolCrystalPuriss
  • Thymol, 98+%
  • THYMOL CRYSTAL PURE
  • ThyMol ,2-Isopropyl-5-Methylphenol,ThyMe caMphor
  • Thymol Crystal
  • 5-Methy-2-iso-propyl-l-phenol 6-Isopropyl-3-methylphenol 6-Isopropyl-m-cresol
  • P-CYMEN-3-OL
  • PHYMOLSULFONPHTHALEIN
  • TB
  • S NO 879
  • THYME CAMPHOR
  • チモール
  • 2-イソプロピル-5-メチルフェノール
  • 6-イソプロピル-m-クレゾール
  • 5-メチル-2-イソプロピルフェノール
  • m-チモール
  • 6-イソプロピル-3-メチルフェノール
  • 3-ヒドロキシ-p-シメン
  • チムカンファー
  • 5-メチル-2-(1-メチルエチル)フェノール
  • チモ-ル
  • 6イソプロピルmクレゾル
  • チモール標準品
  • チモール、噴霧試液用
  • テルペン
  • 単環式モノテルペン
  • 生化学
  • 歯科用薬
  • 抗細菌薬
  • 駆虫薬
  • 殺菌薬
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