(+)-アフィディコリン 化学特性,用途語,生産方法
外観
白色〜わずかにうすい黄色, 結晶性粉末〜粉末
溶解性
メチルアルコール, DMSO,希薄な酸に可溶、水に難溶。
用途
1.DNAポリメラーゼαおよびDNA合成に関する研究。2.同調培養試薬
説明
(+)-
Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus
C. aphidicola and shown to have antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-
permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels. Aphidicolin can be used, at 3 μM, to arrest cells in G
1/S phase or to increase gene amplification frequency.
化学的特性
White crystal
使用
(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.
定義
ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi
ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
一般的な説明
A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
(+)-アフィディコリン 上流と下流の製品情報
原材料
準備製品