g-ストロファンチン 化学特性,用途語,生産方法
解説
ウアバイン．キョウチクトウ科Strophanthus gratusやAcokanthera ouabaioの種子中に存在する強心配糖体．加水分解により1 mol のウアバゲニンと1 mol のL-ラムノースを与える．板状晶(八水和物)．融点190 ℃(分解)．[α]25D－31°(メタノール)．光で分解する．水，エタノールに難溶．LD50 17.2 mg/kg(ネズミ，静注)．
説明
One of several
cardiac glycosides that have been used clinically as cardiotonic
agents and diuretics. Ouabain is obtained from the seeds of
Strophanthus gratus, Acokanthera ouabaio, and related species.
It was formerly prescribed under the name strophanthuis as the
purified seed extract.
化学的特性
Ouabain is a white crystalline solid.
一般的な説明
Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
反応プロフィール
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].
健康ハザード
G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
火災危険
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)
生物活性
Selective Na + , K + -ATPase inhibitor.
安全性プロファイル
Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
職業ばく露
Ouabain, similar to digitoxin, is used
to produce rapid digitalization in acute congestive heart
failure. Also recommended in treatment of atrial or nodal
paroxysmal tachycardia and atrial flutter; enzyme inhibitor.
輸送方法
UN1544 Alkaloids, solid, n.o.s., Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
純化方法
It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]
不和合性
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.).
g-ストロファンチン 上流と下流の製品情報
原材料
準備製品