p-アニシジン 化学特性,用途語,生産方法
外観
白色～褐色, 結晶～結晶性粉末
溶解性
水に難溶, アルコール, エーテルに易溶。
用途
ナフトールASSG、ラピッドファストピンクLBなどの染料中間物
用途
有機合成原料(染料)。
化学的特性
Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors. releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).
物理的性質
Yellow to light brown powder, leaflets, solid or crystals with a characteristic amine or ammonialike odor. soluble in ethanol and ether, slightly soluble in water.
使用
p-Anisidine is used mostly for producing dyes, and some smaller quantities are employed in making pharmaceuticals and liquid crystals.
主な応用
p-Anisidine is used as a reagent to indicate the secondary stage of the oxidation, it is one of the three possible isomers of the Anisidine or methoxyaniline. The other two isomers are o-Anisidine (2-methoxyaniline) and m-Anisidine (3-methoxyaniline).
The p-anisidine is widely used as an intermediate in the production of numerous azo and triphenylmethane dyes, and pigments. It is also used in the production of pharmaceuticals including the guaiacol expectorant, as an antioxidant for polymercaptan resins, and as a corrosion inhibitor for steel. Apart from the beneficial use of p-anisidine, it is toxic for human beings. The acute exposure may cause skin irritation, whereas the chronic exposure may cause headaches, vertigo, and blood complications like sulfhemoglobin, and methemoglobin. The oral exposure to anisidine hydrochloride resulted in cancer of the urinary bladder in male and female rats.
https://www.longdom.org/open-access/physicochemical-and-spectroscopic-characterization-of-biofield-energytreated-panisidine-paco-1000102.pdf
製造方法
p-Anisidine is an important intermediate for synthesis of dye, medicine and perfume. Traditional preparation of p-Anisidine uses iron powder or sodium sulfide as reductant, which produces a large amount of waste and results in serious environment pollution problem. Liquid phase catalytic hydrogenation is not only an environmentally benign technique but also of high yield.
Synthesis of p-Anisidine by Hydrogenation with Raney-RuNiC as Catalyst
一般的な説明
P-anisidine appears as brown crystals or dark brown solid. Characteristic amine odor. (NTP, 1992)
空気と水の反応
Insoluble in water.
反応プロフィール
p-Anisidine may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates.
危険性
Strong irritant. Toxic when absorbed
through the skin. Questionable carcinogen.
火災危険
p-Anisidine is flammable.
安全性プロファイル
Moderately toxic by
several routes. A mild sensitizer. May cause
a contact dermatitis. Mutation data reported.
Questionable carcinogen. See also
ANILINE. When heated to decomposition
it emits toxic fumes of Nox
職業ばく露
Anisidines are used in the manufacture
of azo dyes; pharmaceuticals; textile-processing chemicals
Incompatibilities: Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Attacks some coatings
and some forms of plastic and rubber.
発がん性
Available
data were inadequate to evaluate the carcinogenicity
of p-anisidine.
輸送方法
UN2431 Anisidines, Hazard Class: 6.1; Labels:
6.1-Poisonous materials
純化方法
Crystallise p-anisidine from H2O or aqueous EtOH. Dry it in a vacuum oven at 35o for 6hours and store it in a dry box. [More et al. J Am Chem Soc 108 2257 1986.] Purify it also by vacuum sublimation [Guarr et al. J Am Chem Soc 107 5104 1985]. [Beilstein 13 IV 1015.]
廃棄物の処理
Dissolve in combustible solvent
(alcohols, benzene, etc.) and spray solution into furnace
equipped with afterburner and scrubber, or burn spill
residue on sand and soda ash absorbent in a furnace.
p-アニシジン 上流と下流の製品情報
原材料
準備製品
2-アミノ-6-メトキシベンゾチアゾール
cleaner LS
４ニトロベンジル＝（４Ｒ，５Ｒ，６Ｓ）３［（ジフェノキシホスホリル）オキシ］６［（Ｒ）１ヒドロキシエチル］４メチル７オキソ１アザビシクロ［３．２．０］ヘプタ２エン２カルボキシラト
アニソニトリル
1-(4-メトキシフェニル)ピペラジン二塩酸塩
2-[[4-(ジメチルアミノ)フェニル]アゾ]-6-メトキシ-3-メチルベンゾチアゾール-3-イウム·メチルスルファート
2'-(アセチルアミノ)-4'-[ビス(2-アセトキシエチル)アミノ]-6-ブロモ-2,4-ジニトロ-5'-エトキシアゾベンゼン
インドメタシン
ｔ－ブチルヒドロキシアニソール
1-(p-メトキシフェニル)ピペラジン
5-メトキシ-1H-インダゾール-3-カルボン酸
Reactive Red Violet X-2R
N-(4-メトキシフェニル)-3-ヒドロキシナフタレン-2-カルボアミド
2-ヒドロキシ-N-(4-メトキシフェニル)-11H-ベンゾ[a]カルバゾール-3-カルボアミド
4-メトキシベンゼンジアゾニウムテトラフルオロボラート
6-メトキシ-2-メチルキノリン
イソシアン酸4-メトキシフェニル
N-(p-メトキシフェニル)-p-フェニレンジアミン·0.5硫酸塩
p-アセトアニシジド
4-メトキシ-2-ニトロアニリン
4-クロロ-N1-(4-メトキシフェニル)安息香酸ヒドラジド
6-メトキシベンゾチアゾール-2-カルボン酸
2-(4-メトキシフェニル)ヒドラジンスルホン酸ナトリウム
(p-メトキシフェニル)チオ尿素
2,5-ジクロロ-4-アミノフェノール
6-キノリノール
6-メトキシキノリン
6-メトキシ-4-メチルキノリン
5-メトキシイサチン
2-[[(4-メトキシフェニル)メチルヒドラゾノ]メチル]-1,3,3-トリメチル-3H-インドリウム·メチルスルファート
2-シアノ-6-メトキシベンゾチアゾール
ピリミジン-4-アミン
6-メトキシ-2-メチルベンゾチアゾール
2-CARBOMETHOXY-6-METHOXYBENZOTHIAZOLE
4-クロロ-2-(4-メトキシフェニルアミノ)安息香酸
ミカシオンレッドバイオレットR
4-(4-メトキシアニリノ)ベンゼンジアゾニウム
2,9-ビス(4-メトキシフェニル)アントラ[2,1,9-def:6,5,10-d'e'f']ジイソキノリン-1,3,8,10(2H,9H)-テトラオン
5-メトキシ-1H-ベンゾイミダゾール
Catonic Yellow X-8GL