亜りん酸トリメチル 化学特性,用途語,生産方法
用途
殺虫?殺菌剤原料、プラスチック?木材難燃剤、高分子重合触媒、ガソリン添加剤、塗料添加剤
化学的特性
Trimethyl phosphite is a colorless liquid.
Distinctive pungent, pyridine-like odor. The Odor
Threshold is 0.0001 ppm.
使用
Trimethyl phosphite has been used primarily as an intermediate in the manufacture of pesticides and the synthesis of organophosphate insecticides. It is also used as a fire retardants in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst.
定義
ChEBI: Trimethyl phosphite is an organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds. It has a role as an alkylating agent.
調製方法
Produced via a reaction between phosphorus trichloride and
methanol in the presence of a tertiary amine catalyst such as
diethylaniline.
一般的な説明
Trimethyl phosphite appears as a clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in water. Vapors heavier than air. It is used in making pesticides, flame retardants and organophosphorous additives.
空気と水の反応
Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol. Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol. The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC).
反応プロフィール
As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).
健康ハザード
Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.
LD50 value, oral (rats): 1600 mg/kg
Teratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite.
The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..
火災危険
Special Hazards of Combustion Products: Toxic fumes of PO x
安全性プロファイル
Moderately toxic by
ingestion and skin contact. An experimental
teratogen. A severe skin and eye irritant.
Flammable liquid when exposed to heat,
flame, or oxidizers. To fight fire, use water,
foam, fog, CO2. Violent explosive reaction
on contact with magnesium perchlorate or
trimethyl platinum(IV) azide tetramer. When
heated to decomposition it emits toxic
fumes of POx. An intermediate in the
production of pesticides, fire retardants, and
organic phosphorus additives. See also
ESTERS.
職業ばく露
Trimethyl phosphite is a flame
retardant, and used as an intermediate in the manufacture
of a number of pesticides, and organophosphorus
additives.
発がん性
Trimethyl phosphite was genotoxic in
mouse lymphoma assays but was not mutagenic
in various bacterial assays.
輸送方法
UN2329 Trimethyl phosphite, Hazard Class: 3;
Labels: 3-Flammable liquid.
純化方法
Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]
不和合性
Vaor May form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, peroxides,
permanganates, perchlorates, chlorine, bromine, fluorine,
etc.); contact may cause fires or explosions. Violent
reaction with magnesium perchlorate.
Keep away from alkaline materials, strong bases, strong
acids, oxoacids, epoxides. Reacts (hydrolyzes) with water.
Incompatible with air, moisture.
廃棄物の処理
Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.
亜りん酸トリメチル 上流と下流の製品情報
原材料
準備製品