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ダポキセチン塩酸塩

ダポキセチン塩酸塩 化学構造式
129938-20-1
CAS番号.
129938-20-1
化学名:
ダポキセチン塩酸塩
别名:
ダポキセチン塩酸塩;(S)-N,N-ジメチル-3-(1-ナフチルオキシ)-1-フェニルプロピルアミン塩酸塩;(S)-N,N-ジメチル-α-[2-(1-ナフチルオキシ)エチル]ベンジルアミン塩酸塩;(S)-N,N-ジメチル-3-(ナフタレン-1-イルオキシ)-1-フェニルプロパン-1-アミン塩酸塩
英語化学名:
Dapoxetine hydrochloride
英語别名:
Priligy;LY-21044;LY-210448;DAPOXETINE HCL;Rimonabant 75000;DL-Dapoxteine HCL;(S)-N,N-dimethyl-3-;Mixed spin Dapoxetine;Dapoxetine hcl for R&D;LY-210448 hydrochloride
CBNumber:
CB7104314
化学式:
C21H23NO·HCl
分子量:
341.88
MOL File:
129938-20-1.mol

ダポキセチン塩酸塩 物理性質

融点 :
175-1790C
比旋光度 :
D +135.78° (c = 2.18 in methanol)
貯蔵温度 :
-20°C Freezer
溶解性:
DMSO: ≥20mg/mL
外見 :
powder
色:
white
光学活性 (optical activity):
[α]/D +125 to +135°, c = 1 in methanol
Merck :
14,2821
CAS データベース:
129938-20-1(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,N
Rフレーズ  22-36-50/53
Sフレーズ  36-60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HSコード  29221990
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H413 長期的影響により水生生物に有害のおそれ 水生環境有害性、慢性毒性 4
注意書き
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ダポキセチン塩酸塩 価格 もっと(15)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC092483 ダポキセチン塩酸塩
Dapoxetine hydrochloride
129938-20-1 1g ¥49500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01FLC092483 ダポキセチン塩酸塩
Dapoxetine hydrochloride
129938-20-1 5g ¥165700 2018-12-26 購入
東京化成工業 D4761 ダポキセチン塩酸塩 >98.0%(HPLC)
Dapoxetine Hydrochloride >98.0%(HPLC)
129938-20-1 5g ¥33300 2018-12-04 購入
東京化成工業 D4761 ダポキセチン塩酸塩 >98.0%(HPLC)
Dapoxetine Hydrochloride >98.0%(HPLC)
129938-20-1 1g ¥9800 2018-12-04 購入
Sigma-Aldrich Japan D7071 ≥98% (HPLC)
Dapoxetine hydrochloride ≥98% (HPLC)
129938-20-1 10mg ¥22700 2018-12-25 購入

ダポキセチン塩酸塩 化学特性,用途語,生産方法

効能

抗うつ薬, 選択的セロトニン再取り込み阻害薬

説明

PE is the most common form of male sexual dysfunction affecting 20-40% of men globally at some point in their lives. Ejaculation is a reflex comprising different sensory pathways, motor centers, and nerve pathways. This ejaculatory reflex has been shown to be controlled primarily by serotonin and dopamine. Dapoxetine is a short-acting SSRI. It is differentiated from the existing SSRI treatments for PE by the fact that it can be administered on an as-needed basis. In healthy subjects, dapoxetine is rapidly absorbed after oral administration with a peak plasma concentration (Tmax) occurring between 1.4 and 2 h.
Dapoxetine also showed statistically significant improvements in perceived control over ejaculation, PE-related personal distress, and other patient-reported outcomes in all five trials. Dapoxetine treatment was generally well tolerated, with low incidences of discontinuation syndrome, sexual dysfunction, and treatment-emergent mood symptoms. The most common adverse events with dapoxetine included nausea, diarrhea, headache, dizziness, and somnolence.

化学的特性

Off-white Cryst

Originator

Lilly (US)

使用

Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men. D

使用

A selective serotonin reuptake inhibitor

使用

Selective serotonin reuptake inhibitor (SSRI)

brand name

Priligy

Chemical Synthesis

Dapoxetine can be synthesized in four chemical steps starting from R-1phenyl- 1,3-propanediol via selective tosylation of the primary hydroxy group with p-toluenesulfonyl chloride, triethylamine and 4-(dimethylamino) pyridine (DMAP), and subsequent condensation with 1naphthol by means of sodium- or lithium hydroxide to yield R-3-(1naphthyloxy)- 1-phenylpropanol as the key intermediate. Conversion of the alcohol group to the corresponding mesylate with methanesulfonyl chloride, triethylamine, and DMAP, followed by treatment with dimethylamine affords dapoxetine, which is then acidified to its hydrochloride salt.

ダポキセチン塩酸塩 上流と下流の製品情報

原材料

準備製品


ダポキセチン塩酸塩 生産企業

Global( 298)Suppliers
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Beijing Yibai Biotechnology Co., Ltd
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
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Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
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career henan chemical co
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Hebei Huanhao Biotechnology Co., Ltd.
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Shenzhen Nexconn Pharmatechs Ltd
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Chemwill Asia Co.,Ltd.
86-21-51086038
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129938-20-1(ダポキセチン塩酸塩)キーワード:


  • 129938-20-1
  • D-Dapoxetine Hydrochloride
  • (S)-N,N-dimethyl-3-
  • (S)-Dapoxetine hydrochloride
  • Dapoxetine hydrochloride|S1869
  • Dapoxetine hydrochloride(Priligy)
  • (αS)-N,N-DiMethyl-α-[2-(1-naphthalenyloxy)ethyl]benzeneMethanaMine
  • (S)-N,N-DIMETHYL-Α-[2-(1-NAPHTHALENY-LOXY)ETHYL]BENZENEMETHANAMINE HYDROCHLORIDE
  • Dapoxetine hydrochloride, 98%, a short-acting novel selective serotonin reuptake inhibitor
  • LY-210448 hydrochloride
  • Priligy
  • PRILIGY;LY-210448 HYDROCHLORIDE
  • Dapoxetine/Dapoxetine HCl/Dapoxetine hydrochloride
  • Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, hydrochloride, (S)-
  • D-(+)N,N-diMethyl-3-(naphthalen-1-yloxy)
  • (αS)- N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-benzenemethanamine, hydrochloride (1:1)
  • (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidDapoxetine hydrochloride
  • Dapoxetine hydrochloride (1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
  • S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride
  • Mixed spin Dapoxetine
  • (1s)-n,n-dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
  • DAPOXETINE HCL
  • DAPOXETINE HYDROCHLORIDE CHEMISTRY PURE 98.5% HPLC
  • Rimonabant 75000
  • (aS)-N,N-Dimethyl-a-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
  • LY-21044
  • ((S)-(+)-N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride)
  • (S)-(+)--N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine
  • Dapoxetine hydrochloride
  • (aS)-N,N-Dimethyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
  • LY-210448
  • ダポキセチン塩酸塩
  • (S)-N,N-ジメチル-3-(1-ナフチルオキシ)-1-フェニルプロピルアミン塩酸塩
  • (S)-N,N-ジメチル-α-[2-(1-ナフチルオキシ)エチル]ベンジルアミン塩酸塩
  • (S)-N,N-ジメチル-3-(ナフタレン-1-イルオキシ)-1-フェニルプロパン-1-アミン塩酸塩
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