ダポキセチン塩酸塩
ダポキセチン塩酸塩 物理性質
- 融点 :
- 175-1790C
- 比旋光度 :
- D +135.78° (c = 2.18 in methanol)
- 貯蔵温度 :
- room temp
- 溶解性:
- DMSO：20mg/mL以上
- 外見 :
- 粉
- 色:
- 白い
- 光学活性 (optical activity):
- [α]/D +125 to +135°, c = 1 in methanol
- Merck :
- 14,2821
- InChI:
- InChI=1/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/s3
- InChIKey:
- IHWDIQRWYNMKFM-OZYVVJTJNA-N
- SMILES:
- O(C1=CC=CC2C=CC=CC1=2)CC[C@@H](C1C=CC=CC=1)N(C)C.Cl |&1:13,r|
- CAS データベース:
- 129938-20-1(CAS DataBase Reference)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCD185700 |
ダポキセチン塩酸塩
Dapoxetine Hydrochloride |
129938-20-1 |
10mg |
￥26100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCD185700 |
ダポキセチン塩酸塩
Dapoxetine Hydrochloride |
129938-20-1 |
25mg |
￥30300 |
2023-06-01 |
購入 |
|
東京化成工業
|
D4761 |
ダポキセチン塩酸塩 >98.0%(HPLC)
Dapoxetine Hydrochloride
>98.0%(HPLC) |
129938-20-1 |
1g |
￥10800 |
2024-03-01 |
購入 |
|
東京化成工業
|
D4761 |
ダポキセチン塩酸塩 >98.0%(HPLC)
Dapoxetine Hydrochloride
>98.0%(HPLC) |
129938-20-1 |
5g |
￥36700 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
D7071 |
ダポキセチン 塩酸塩 ≥98% (HPLC)
Dapoxetine hydrochloride ≥98% (HPLC) |
129938-20-1 |
10mg |
￥23600 |
2024-03-01 |
購入 |
ダポキセチン塩酸塩 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
抗うつ薬, 選択的セロトニン再取り込み阻害薬
説明
Dapoxetine hydrochloride, belonging to the class of SSRIs, was the first drug originally approved for the on-demand treatment of men with PE by seven European countries in 2008.
Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine is a short-acting SSRI. It is differentiated from the existing SSRI treatments for PE by the fact that it can be administered on an as-needed basis. In healthy subjects, dapoxetine is rapidly absorbed after oral administration with a peak plasma concentration (Tmax) occurring between 1.4 and 2h.
化学的特性
Dapoxetine hydrochloride is a white to slightly yellow powder. It is freely soluble in methanol, propylene glycol, some organic solvents (eg. N,N-dimethylformamide) , slightly soluble in ethanol and almost insoluble in water. It is a BCSI class II compound, and poor solubility is a key factor affecting the difference in clinical efficacy. Dapoxetine hydrochloride exists in various crystal forms, the solubility of different crystal forms is quite different, and there is a phenomenon of phase and transformation between crystal forms.
使用
Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men.
一般的な説明
Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.
Mode of action
The mechanism of action of dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre- and post-synaptic receptors. Dapoxetine is a centrally-acting SSRI that modulates serotonin levels in relevant areas such as the lateral paragigantocellular nucleus through inhibition of the serotonin transporter (SERT). This compound also decreases peak amplitude and accelerates the decay rate of current inactivation in a variety of voltage-gated K+ channels.
ダポキセチン塩酸塩 上流と下流の製品情報
原材料
準備製品
ダポキセチン塩酸塩 生産企業
Global( 628)Suppliers
129938-20-1(ダポキセチン塩酸塩)キーワード:
- 129938-20-1
- Dapoxetine hydrochloride
(1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
- S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride
- Mixed spin Dapoxetine
- (1s)-n,n-dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
- Rimonabant 75000
- (aS)-N,N-Dimethyl-a-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
- LY-21044
- ((S)-(+)-N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride)
- (S)-(+)--N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine
- Dapoxetine hydrochloride
- (aS)-N,N-Dimethyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
- LY-210448
- Dapoxetine hcl for R&D
- naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
- (S)-Dapoxetine hydrochloride
- (αS)-N,N-DiMethyl-α-[2-(1-naphthalenyloxy)ethyl]benzeneMethanaMine
- Dapoxetine hydrochloride|S1869
- Dapoxetine hydrochloride(Priligy)
- N,N-DiMethyl-1-phenyl-3-(1-naphthalenyloxy)propanaMinehydrochloride
- (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride
- D-(+)N,N-diMethyl-3-(naphthalen-1-yloxy)
- (αS)- N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-benzenemethanamine, hydrochloride (1:1)
- (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidDapoxetine hydrochloride
- Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, hydrochloride, (S)-
- (S)-N,N-DIMETHYL-Α-[2-(1-NAPHTHALENY-LOXY)ETHYL]BENZENEMETHANAMINE HYDROCHLORIDE
- Dapoxetine hydrochloride, 98%, a short-acting novel selective serotonin reuptake inhibitor
- DapoxetineHydrochloride>
- Dapoxetine hydrochloride,>98%
- Dapoxetine Hydrochlorid Salt
- (S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropylamine Hydrochloride
- ダポキセチン塩酸塩
- (S)-N,N-ジメチル-3-(1-ナフチルオキシ)-1-フェニルプロピルアミン塩酸塩
- (S)-N,N-ジメチル-α-[2-(1-ナフチルオキシ)エチル]ベンジルアミン塩酸塩
- (S)-N,N-ジメチル-3-(ナフタレン-1-イルオキシ)-1-フェニルプロパン-1-アミン塩酸塩