シタグリプチンリン酸塩
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- CAS番号.
- 654671-78-0
- 化学名:
- シタグリプチンリン酸塩
- 别名:
- シタグリプチンリン酸塩
- 英語名:
- Sitagliptin phosphate
- 英語别名:
- Sitagliptin Phosphat;3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t;(3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;SIT-11;CS-1358;sitagpliptin;Sitagliptin, MK 0431;Sitagliptin phosphate;Sitagliptin Phosphatec;Sitagliptin phosphate salt
- CBNumber:
- CB71179744
- 化学式:
- C16H15F6N5O.H3PO4
- 分子量:
- 505.31
- MOL File:
- 654671-78-0.mol
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シタグリプチンリン酸塩 物理性質
- 融点 :
- 202-204°C
- 貯蔵温度 :
- -20°C Freezer
- 溶解性:
- メタノール（少し、加熱）、水（少し、超音波処理）
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
- InChI:
- InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)
- InChIKey:
- IQFYVLUXQXSJJN-UHFFFAOYSA-N
- SMILES:
- C(C1=CC(F)=C(F)C=C1F)C(N)CC(=O)N1CCN2C(C(F)(F)F)=NN=C2C1.P(O)(O)(O)=O
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
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| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
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| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
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シタグリプチンリン酸塩 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
シタグリプチンリン酸塩 化学特性,用途語,生産方法
説明
Sitagliptin is the first novel dipeptidyl peptidase IV inhibitor
from Merck for the treatment of type 2 diabetes without
weight gain and the incidence of hypoglycemia was similar
to placebo. Sitagliptin acts by enhancing the body’s incretin
system, which helps to regulate glucose by affecting β
and α cells in the pancreas.
化学的特性
White Solid
使用
A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.
一般的な説明
Sitagliptin phosphate is the 1:1 phosphoric acid salt ofsitagliptin free base (i.e., (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)-2-butanamine), and is marketed(Junuvia, 2006) in 25-, 50-, and 100-mg tablets. Acombination product with metformin (Janumet, 2007) intwo strengths (50 mg/500 mg and 50 mg/1,000 mgsitagliptin/metformin) is also available, and sitagliptin mayalso be prescribed with a thiazolidinedione, or possibly a sulfonylurea.The phosphate salt provides very high water solubility.The bioavailability of orally administered sitagliptinis～87%. The drug exhibits relatively low plasma protein binding (～38%), a relatively large volume of distribution(198 L), and a terminal elimination half-life of 12 hours.About 79% of a 100-mg oral dose is excreted unchanged inurine, the balance as trace-level metabolites (CYP3A4, lessercontribution by CYP2C8) in urine or feces: 87% of administeredradioactivity is excreted in urine, and 13% in feces.Active tubular excretion is reported to play a key role in renalclearance of unchanged drug, and may be mediated at least inpart via the organic anion transporter hOAT-3.
シタグリプチンリン酸塩 上流と下流の製品情報
原材料
準備製品
シタグリプチンリン酸塩 生産企業
Global( 357)Suppliers
シタグリプチンリン酸塩 スペクトルデータ(1HNMR)
654671-78-0(シタグリプチンリン酸塩)キーワード:
- 654671-78-0
- 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine-phosphate
- Sitagliptin phosphate
- 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
- sitagpliptin
- Sitagliptin phosphate 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
- Sitagliptin phosphate/Sitagliptin phosphate Monohydrate/Sitagliptin
- Sitagliptin phosphate (Cas:654671-78-0...
- (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
- 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate (1:1)
- Sitagliptin, MK 0431
- CS-1358
- Sitagliptin phosphate salt
- 99% Sitagliptin Phosphate?
- Sitagliptin phosphate USP/EP/BP
- Sitagliptin phosphate (API)
- Sitagliptin PhosphateQ: What is
Sitagliptin Phosphate Q: What is the CAS Number of
Sitagliptin Phosphate Q: What is the storage condition of
Sitagliptin Phosphate
- Sitagliptin Phosphatec
- 3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t
- (3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
- Sitagliptin Phosphat
- SIT-11
- Sitagliptin Impurity 19 Phosphate
- Sitagliptin Phosphate (Monohydrate and Anhydrous)
- Sitagliptin Impurity 14 Phosphate
- Siagliptin phosphate monohydrate
- シタグリプチンリン酸塩