エルデカルシトール

エルデカルシトール 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

エルデカルシトール 化学特性,用途語,生産方法

効能

乾癬治療薬, 骨粗鬆症治療薬, ビタミンD受容体作動薬

商品名

エディロール (中外製薬); エディロール (中外製薬)

説明

Eldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D’s central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis. Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone.

使用

Eldecalcitol is a derivative of vitamin D3 (V676045) which is the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity.

定義

ChEBI: A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2.

臨床応用

Eldecalcitol is a vitamin D3 analog approved in Japan for the treatment of osteoporosis. Itwasdiscoveredby Chugai and co-developed with Taisho. Eldecalcitol, a hormonally active calcitrol analog, regulates calcium and bone metabolism. The drug was approved on the basis of results from randomized, double-blinded, parallelgroup, phase III studies taking place over three years that showed eldecalcitol to significantly lower incidence of new vertebral fractures compared to those receiving the comparator drug alfacalcidol. Discovery and SAR studies of vitamin D3 analogs leading to the identification of eldecalcitol have been reported. In addition, multiple syntheses, including parallel approaches, have been reported in publications and patents.

エルデカルシトール 上流と下流の製品情報

原材料

準備製品

エルデカルシトール 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3586	58
Nanjing Shizhou Biotechnology Co., Ltd	+86-15850508050 +86-15850508050	sean.lv@synzest.com	China	323	58

104121-92-8(エルデカルシトール)キーワード:

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• 104121-92-8
• 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
• Eldecalcitol
• ED-71
• (1R,Z)-5-((E)-2-((1R,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol
• 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3
• Eldecalcitol(ED-71)
• 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitaMin D3
• (1S,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
• El calciditol
• Eldecalcitol {2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3}
• 1,3-Cyclohexanediol, 2-(3-hydroxypropoxy)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,2R,3R,5Z)-
• (1R,2R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
• 104121-92-8 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
• (1R,2R,3R,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-Hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol
• Eldecalcitol CRS
• Aidit, calcitriol
• Idecalcitol
• エルデカルシトール
• エルデカルシトール (JAN)
• 1α,25-ジヒドロキシ-2β-(3-ヒドロキシプロポキシ)ビタミンD3
• (5Z,7E)-2β-(3-ヒドロキシプロポキシ)-9,10-セココレスタ-5,7,10(19)-トリエン-1α,3β,25-トリオール
• 2β-(3-ヒドロキシプロポキシ)カルシトリオール
• (14S)-2β-(3-ヒドロキシプロポキシ)-1α,25-ジヒドロキシコレカルシフェロール
• 2β-(3-ヒドロキシプロポキシ)-1α,25-ジヒドロキシコレカルシフェロール
• (1R,2R,3R,5Z,7E)-2-(3-ヒドロキシプロポキシ)-9,10-セココレスタ-5,7,10(19)-トリエン-1,3,25-トリオール
• 1α,25-ジヒドロキシ-2β-(3-ヒドロキシプロポキシ)コレカルシフェロール
• (1R,2R,3R,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-6-ヒドロキシ-6-メチルヘプタン-2-イル]-7a-メチル-オクタヒドロ-1H-インデン-4-イリデン]エチリデン}-2-(3-ヒドロキシプロポキシ)-4-メチリデンシクロヘキサン-1,3-ジオール
• (1R,2R,3S)-5-{2-[(1R,3aS,7aR)-1-[(2R)-6-ヒドロキシ-6-メチルヘプタン-2-イル]-7a-メチル-オクタヒドロ-1H-インデン-4-イリデン]エチリデン}-2-(3-ヒドロキシプロピル)-4-メチリデンシクロヘキサン-1,3-ジオール
• 2β-(3-ヒドロキシプロピル)-9,10-セココレスタ-5,7,10(19)-トリエン-1α,3β,25-トリオール
• 2β-(3-ヒドロキシプロポキシ)-1α,25-ジヒドロキシビタミンD3
• ED-71