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ビルダグリプチン

ビルダグリプチン  化学構造式
274901-16-5
CAS番号.
274901-16-5
化学名:
ビルダグリプチン
别名:
ビルダグリプチン;ビルダグリプチン (JAN)
英語化学名:
Vildagliptin
英語别名:
Galvus;Laf 237;ZoMelis;Vigliptin;Vildaliptin;NVP-LAF 237;Vildgliptin;Vildagliptin;Unii-I6B4B2U96p;Vildagliptin API
CBNumber:
CB71449010
化学式:
C16H15F6N5O?H3O4P?H2O
分子量:
303.4
MOL File:
274901-16-5.mol

ビルダグリプチン 物理性質

融点 :
153-155?C
比旋光度 :
-78.3° (c = 9.73 in methanol)
沸点 :
531.3±50.0 °C(Predicted)
比重(密度) :
1.27
闪点 :
275.1℃
貯蔵温度 :
-20°C Freezer
酸解離定数(Pka):
15.05±0.40(Predicted)
CAS データベース:
274901-16-5(CAS DataBase Reference)

安全性情報

Rフレーズ  28-38-41-48
Sフレーズ  24/25-26-28-36/37/39
RIDADR  3077
HSコード  29339900

ビルダグリプチン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ビルダグリプチン 化学特性,用途語,生産方法

効能

糖尿病治療薬, DPP-4阻害薬

商品名

エクア (ノバルティスファーマ)

説明

Vildagliptin, a DPP-4 inhibitor, was launched for the oral treatment of type 2 diabetes. Vildagliptin is the second DPP-4 inhibitor to reach the market behind sitagliptin, which was introduced in 2006. DPP-4 inhibitors act by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase the synthesis and release of insulin from pancreatic βcells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic α cells, which leads to reduced hepatic glucose production. However, although GLP-1 and GIP effectively lower blood glucose, they are short-lived as a result of rapid inactivation by the ubiquitous serine protease DPP-4. By inhibiting DPP-4, vildagliptin increases the concentration and duration of active incretin levels, which in turn results in increased insulin release and decreased glucagon levels in a glucose-dependent manner. Both vildagliptin and sitagliptin are potent, competitive, reversible inhibitors of DPP- 4 (IC50=3.5 and 18 nM, respectively), and they both show slow, tight-binding inhibition kinetics.

化学的特性

White Solid

Originator

Novartis (US)

使用

Vildagliptin (LAF-237) inhibits DPP?4 with IC50 of 2.3 nM

使用

The major metabolite of Vildagliptin

使用

Labelled Vildagliptin. It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic.

使用

A metabolite of Vildagliptin

brand name

Galvus

副作用

The most common adverse events reported in patients receiving vildagliptin included headache, nasopharyngitis, cough, constipation, dizziness, and increased sweating. Vildagliptin is not recommended for patients with liver impairment.

Chemical Synthesis

Vildagliptin is chemically derived in three steps starting from L-prolinamide via acylation with chloroacetyl chloride to produce 1-(chloroacetyl)-L-prolinamide, subsequent dehydration of the carboxamide group to the nitrile with trifluoroacetic anhydride, and condensation of the 1-(chloroacetyl)-L-prolinenitrile intermediate with 3-hydroxyadamantan-1-amine.

ビルダグリプチン 上流と下流の製品情報

原材料

準備製品


ビルダグリプチン 生産企業

Global( 322)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Echemi Group
18905328650 86-18905328650
pharma@echemi.com CHINA 194 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838
chloewu@chicopharm.cn CHINA 341 58
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 301 58

274901-16-5(ビルダグリプチン )キーワード:


  • 274901-16-5
  • pharma API Vildagliptin
  • 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine
  • Vildagliptin, 97%, DPP-4 inhibitor
  • Best Quality Vildagliptin with best price CAS NO.274901-16-5
  • China Top quality CAS:274901-16-5 Vildagliptin CAS NO.274901-16-5
  • Top quality API Vildagliptin with best price
  • API Vildagliptin CAS 274901-16-5
  • pharma API cas 274901-16-5 Vildagliptin
  • VILDAGLIPTIN CAS NO:274901-16-5
  • Vildagliptin API
  • 2-Pyrrolidinecarbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)aMino]acetyl]-, (2S)-
  • Vildagliptin (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
  • Vildaliptin
  • LAF237; GALVUS; NVP-LAF 237; ZOMELIS
  • Vigliptin
  • (S)-1-[2-[(3-Hydroxyadamant-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
  • Vildagliptin 、VildagliptinAPI
  • Vildagliptin 2-Pyrrolidinecarbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-,
  • Vildagliptin
  • Vildagliptin (NVP-LAF 237)
  • (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
  • 2-Pyrrolidinecarbonitrile, 1-(((3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)amino)acetyl)-, (2S)-
  • Galvus
  • Laf 237
  • Unii-I6B4B2U96p
  • Vidagliptin (see vildagliptin)
  • (2S)-1-(2-((3-hydroxyadaMantan-1-yl)aMino)acetyl)pyrrolidine-2-carbonitrile
  • 1-[2-(3-HydroxyadaMant-1-ylaMino)acetyl]pyrrolidine-2(S)-carbonitrile
  • (S)-1-[2-((5S,7S)-3-hydroxy-adaMantan-1-ylaMino)-acetyl]-pyrrolidine-2-carbonitrile
  • Vildagliptin (LAF-237)
  • ビルダグリプチン
  • ビルダグリプチン (JAN)
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